Award winning researchers reveal potential new role for Glivec
...olicies." Dr McArthur said that one challenge the oncology community faced was working with industry and regulatory agencies to develop strategies for approving novel agents that displayed significant activity in rare diseases. "Possible approaches include registries," he said, "but ultimately, international...Final Alert: 16th EORTC NCI AACR Symposium
...opean, American and other international experts in oncology gathered in Geneva to share findings on the latest research on new molecular targets, designer diagnostics and prognostics, smart drugs and other novel approaches to treatment....Tiny molecules have big potential as cancer drugs, Stanford researcher believes
..." he said. "There are very few rationally designed oncology drugs in use today that are made with a specific target in mind." Designing an inhibitor requires knowing which protein to inhibit and what the protein does. Finding out the latter is a particularly difficult task in the case of cathepsins because of...The telomere crisis: A crucial stage in breast cancer
...d a professor of laboratory medicine and radiation oncology at UCSF, is one of the paper's lead authors, with Koei Chin and Britt Marie Ljung of UCSF; Carlos Ortiz de Solorzano, Paul Yaswen, and Martha Stampfer of Berkeley Lab; and Stephen J. Lockett from the National Cancer Institute. In the breast, cells i...Malignant cancer cells generate mice through cloning
...ol mice. According to Lynda Chin of Dana-Farber's oncology department, this research opens up the door to developing cancer animal models in which researchers could ask epigenetic questions. "Although studies are ongoing, these findings have provided initial clues of the relative contributions of the epigene...AACR applauds FDA decision to create new office of oncology drug products
...R) will streamline the review of applications for oncology drugs and biologics, thereby speeding the development of new therapies. To support this new office and coordinate work performed throughout the FDA Centers related to the prevention, diagnosis, and treatment of cancer, the FDA is also creating an Onc...New drug shows promise against Gleevec resistance in mice
...of the truly spectacular success stories in modern oncology is the development and implementation of Gleevec, a drug that virtually halts the progress of chronic myeloid leukemia. Yet for some patients who harbor particularly stubborn genetic mutations, Gleevec fails miserably. Now, Howard Hughes Medic...North Shore-LIJ research collaboration with Correlogic Systems to advance ovarian cancer blood test
... project, John Lovecchio, MD, chief of gynecologic oncology for the North Shore-LIJ Health System, is playing a pivotal role. "Upon validation, this blood test can dramatically change the lives of women at high risk for ovarian cancer," said Dr. Lovecchio. "When caught very early, the survival rate can be as ...Why lung cancer in women is different from men
...earch. The WALC board is composed of leading women oncology health care professionals in the United States and Canada, along with members of women's advocacy groups and the lay public. For more information on Loyola University Health System, log onto http://www.luhs.org ....Shortened chromosomes linked to early stages of cancer development
... and associate professor of urology, pathology and oncology at Johns Hopkins. "Therefore, intervention strategies aimed at preventing, or even reversing, telomere shortening may be effective in lowering cancer incidence. And assessing telomere length may provide a new direction for cancer prevention studies,...Kinase backgrounder: Iressa discovery part of major kinase project at Dana-Farber
...avior," recalls Meyerson, a molecular and cellular oncology researcher whose chief interest is lung cancer. "Bill said, 'Let's start with the [mutant] kinases, because there are already drugs that can inhibit them,'" Meyerson says. He agreed. "The biggest impact we could have on cancer would be to find mutati......rresponding author and professor of pediatrics and oncology at The Johns Hopkins Kimmel Cancer Center. Dr. Arceci and his colleagues focused on PASG (Proliferation Associated SNF2-like Gene). PASG encodes a SWI/SNF protein family member that facilitates DNA methylation (the addition of a methyl (CH3) group to...MIT aims radar research at breast cancer
...ery," said William C. Dooley, director of surgical oncology at the University of Oklahoma Breast Institute and principal investigator of the ongoing study. "With this focused heat treatment, it may be possible for the surgeon to provide better margins for the patient and possibly avoid additional treatment pr...First large-scale trial of genetically personalised treatment for breast cancer to start soon
...Breast International Group and head of the medical oncology department at the Institut Jules Bordet, Brussels, said: "The traditional approach to clinical research in cancer has been the comparison of treatments through randomized clinical trials, with the extrapolation of an average benefit in a patient pop...Johns Hopkins gene hunters pinpoint new cancer gene target
...or Velculescu, M.D., Ph.D., assistant professor of oncology and senior author of the research. In their current experiments, the scientists sequenced the molecular code of the genes in this lipid kinase family and found mistakes in the nucleotides, or DNA building blocks, in one particular gene, called PIK3C...AACR awards scholarships to minority and underrepresented scientists
... Grey Leventhal, who began her career in pediatric oncology at the National Cancer Institute, conducting clinical and laboratory research on leukemia and other childhood cancers. Subsequently, she served on the faculty of the Johns Hopkins University School of Medicine, until her own life was claimed by canc...USC researchers link unusual DNA structure to cancer
...4. This is a well-known phenomenon in the world of oncology research and treatment, and is called the 14;18 translocation. "Of all the chromosomal fragile sites in cancer, this is the first one where we've actually understood why it's fragile," Lieber says. "And it's because of this molecular quirk in the Wat...European Society for Medical Oncology Cancer Conference
...hes will be presented, along with state-of-the-art oncology at its finest. Some other special features of the Congress: The first ESMO-Developing Countries Joint Symposium will address disparities of cancer treatment on a global level. A third ESMO Patient Seminar has been organised to enable patients to m...OXiGENE launches significant expansion of its R&D program in ophthalmology
... profile of CA4P gleaned from our numerous ongoing oncology and ophthalmology studies, has stimulated us to ex...ur vascular targeting agents on both major fronts, oncology and ophthalmology." High myopia (extreme near sightedness) is a condition in which the feedback mec...... says William Matsui, M.D., assistant professor of oncology at the Johns Hopkins Kimmel Cancer Center. They found that this multiple myeloma stem cell looks and acts genetically different from the plasma cell. "Because these two cells are biologically different, we may need two therapies one to ki...