Adaptive changes in the genome may provide insight into the genetics of complex disease
...ns and others are not. The findings were published online this week for the journal PublicLibrary of Science Biology in a paper titled "Population History and NaturalSelection Shape Patterns of Genetic Variation in 132 Genes." For the paper,researchers studied the molecular evolution of 132 genes by compreh...New genetic hypothesis for the cause of autism
...ort it, will be published September 8, 2004 in the online edition of the American Journal of Medical Genetics Part A, and will be available via Wiley InterScience at http://www.interscience.wiley.com/journal/ajmg . The role of genetics in autism is believed to be significant because twin studies have foun...Fossils reveal direct link between global warming and genetic diversity in wildlife
...eth A. Hadly published its findings in the Sept. 7 online edition of the journal PloS Biology. "We think we know a lot about how animals might respond to global warming, but we really have very little idea about their actual genetic response to environmental change," said Hadly, an assistant professor of b...Long-term effects of carbon monoxide poisoning are an autoimmune reaction
... Pennsylvania School of Medicine, report this week online in the Proceedings of the National Academies of Sciences, that CO causes profound changes in myelin basic protein (MBP) a major protein constituent of myelin, the protective sheath surrounding neurons. Using an animal model, they showed that the CO-...Flame retardants found on supermarket shelves
...around the world. The report, which was published online Sept. 1 by Environmental Science & Technology , a peer-reviewed journal of the American Chemical Society, the worlds largest scientific society, revealed higher levels of flame retardants in the foods here than similar market studies from other coun...Convulsions in worms mimic epileptic seizures
...of the journal Human Molecular Genetics, published online August 31. "The human brain has 100 billion neurons, whereas the worm has only 302. We know each type of neuron and how they connect to each other," Caldwell explained. "We knew that LIS1 is highly expressed in the nervous system, so we wanted to se...Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
...e National Academy of Sciences and is to be posted online this week. "It's too early to tell whether the abnormal behavior we observed in these mutated mice can be directly connected with human disease. On the other hand, we find it intriguing that members of a Canadian family carrying a mutation in the hu...How an insidious mutation fools DNA replication
...edical Center researchers' findings were published online Aug. 22, 2004, by the journal Nature. The scientists were led by Associate Professor of Biochemistry Lorena Beese, Ph.D., and the paper's lead author was Gerald Hsu, a Duke M.D./Ph.D. student. The other co-authors are Thomas Carell and Matthias Ober ...Researchers improve detection of diverse anthrax strains
...ution. The results are scheduled for publication online this week by the journal Proceedings of the National Academy of Sciences. "This level of detail is not possible without whole genome sequences from multiple strains," said the paper's senior author Dr. Paul Keim, Director of Pathogen Genomics at TG...Advances in tumor angiogenesis Dendritic cells co-opted to the dark side
...Reproduction, report their findings in this week's online publication and the September issue of Nature Medicine. "These results clearly deal with ovarian cancer, but we think that the concept is applicable to solid tumors in general," says Coukos. Ovarian cancer is the leading killer among gynecologic canc...Two warbler species find the West isn't big enough for both of them
...ed UW doctoral work in biology, is being published online Aug. 25 in Biology Letters, a journal of The Royal Society, the United Kingdom's national academy of science. The work was funded by the National Science Foundation, the Society of Integrative and Comparative Biology and the Garrett Eddy Ornithologic...UCSD biologists develop 'super-endurance' strain of mice
...per that will appear in the August 24 issue of the online journal PLoS Biology , the scientists say the inability of these genetically modified mice to generate energy through anaerobic metabolism, the biochemical process used for short sprints or bursts of power, provides them instead with an extraordinar...Why your knees and quads hurt more after running than walking: You're only human
...d running: implications for energy cost," which is online at the Journal of Applied Physiology, one of 14 peer-reviewed journals published by the American Physiological Society. Lead author Andrew A. Biewener is at Department of Organismic and Evolutionary Biology at Harvard University, Boston; Claire T. Fa...Genetically-engineered 'marathon mouse' keeps on running
...nstitute, the researchers published their findings online August 24, 2004, in the journal Public Library of Science Biology. Other co-authors are from Seoul National University in Korea. In their studies, the researchers were exploring the effects of altering the gene for a protein called PPAR-delta -- a...In gene regulation, small is beautiful
...criptional activators. In this research, published online in the Journal of the American Chemical Society earlier this month, small molecule artificial activation domains developed in Mapp's lab were as effective as a natural activation domain at turning on genes. Small molecules have great advantages as a...Genetic clues found for common congenital brain disorder
... 2004, issue of Nature Genetics -- to be published online August 22 -- the researchers show that in humans, loss of one copy of each of two adjacent genes, known as ZIC1 and ZIC4, causes Dandy-Walker. The researchers then used this finding to create a mouse model to allow them to study the developmental bas...Penn scientists identify novel pathway in aneurysms
...Therapeutics, report their findings in this week's online publication and the September issue of Nature Medicine. Funk is now the Canada Research Chair in Molecular, Cellular and Physiological Medicine, Queen's University, Kingston, Canada. "This is the first time anyone has ever shown aneurysm formation a...U of T study identifies possible stem cells in pancreas
...ta cells. Their research, published Aug. 22 in the online edition of Nature Biotechnology, offers hope for the millions of diabetics worldwide who take insulin injections to compensate for defective pancreatic islets. Healthy islets, made up largely of beta cells, release insulin to help regulate the body's...Anti-bacterial additive found in Maryland streams
...on in U.S. water resources. It is published in the online edition of Environmental Science & Technology. "Our study shows that environmental contamination with triclocarban is widespread but greatly underreported because conventional monitoring techniques cannot detect it," said the study's lead author Rolf...... and an initial application August 3, 2004, in the online early edition of the Proceedings of the National Academy of Sciences. Both are at the University of Washington in Seattle. "Understanding naturally occurring mutations has been of great interest because mutations are major drivers of evolution," s...