Tag: "optimization" at biology news

Computer Models Find Cost-Effective Solutions For Species Preservation

...amm and hiscollaborators will report on the use of optimization techniquesto select the right tracts of lands for ... States. Cammfactored those values into a computer optimization model, and theresults provide a more flexible approach as well as a moreeconomical approach. "We fou...

Different Molecular Events Underly Experience-Dependent Loss And Gain Of The Function Of The Developing Brain

...g early postnatal development is essential for the optimization of neuronal connections in the brain. While genetic information is only sufficient for the development of the coarse pattern of connections between nerve cells, use-dependent modifications lead to the adaptation...

Engineering New Enzymes

...#145;unevolved’, and therefore amenable to optimization for specific applications by design or directed evolution. A possible first application of the hybrid is to assist the development of factor Xa directed antitherapeutics. Since factor Xa exhibits a poor ability for crystallization, whic...

First Derivation Of Human Embryonic Stem Cells Reported In Science

...ron's hES cell program include the development and optimization of enabling technologies. These include techniques for the production and scale up of hES cells; the identification of cell differentiation factors; techniques for genetically engineering hES cells, and the development of models to test proposed tra...

Groundwater Remediation: New Tool Offers Improvement

...napproaches. "In previous approaches where optimization has been used for remediationsystem design, cleanup goals were specified as static constraints," he says."This project will involve the direct incorporation of risk assessment into theremediation design process. The decision-maker will be able to vie...

NSF-Supported New Scientists And Engineers Receive Presidential Award

... original application ofgeometric combinatorics to optimization and algorithmic problems, anddevelopment of a series of undergraduate courses on related topics. Janet M. Conrad, Columbia Univ. For original contributions to measuringneutrino mass and connecting the measurement techniques to applications inmedicin...

Simulating protein folding from physical laws

... Scheraga, Proteinstructure prediction by global optimization of a potential energyfunction, Proc. Natl. Acad. ...a, Calculation of protein conformation by global optimization of apotentialenergy function, Proteins: Structure, Function and Genetics, in press. -- J. Lee, A. ...

Yale and Alexion report advance in spinal cord repair

...on. "Therefore, we are nowfocusing our efforts on optimization of product manufacturing and definition ofa potential clinical program for the treatment of patients with spinal cordinjuries." According to the National Spinal Cord Injury Association, at least 200,000patients have suffered a traumatic spinal cord i...

UC Berkeley chemists detail secrets of ionization, reasons behind water's central role in chemistry of life

...way between one state and another is a very famous optimization problem, and our technique is part of the solution to that general class of problems," Chandler said. "This is a big generalization of thermodynamics and statistical mechanics."...

Phenotype MicroArray(TM) can test thousands of cell properties simultaneously

... Other applications for PMs include validation and optimization of drug targets, evaluation of a drugs mode of action, and assessment of cell toxicology. Currently the Phenotype MicroArray technology is optimized for use with bacteria and fungal cells. The company has developed a procedure that facilitates anal...

Corvas presents 3-D molecular structure of matriptase, first structural insight into new class of protease cancer targets

... gene family to accelerate the rational design and optimization of drugs to treat solid tumor cancers. With our collaborators at Max-Planck, we have already generated several proprietary high resolution 3-D structures of matriptase bound to lead small molecule inhibitors. Inhibitors have therapeutic potential a...

Office of Naval Research awards $8.4M to young investigators

...proaches to evaluating sensitivity derivatives for optimization in the development of computational fluid dynamics codes. The goal is to develop more accurate and efficient computer codes for fluid dynamics in hydrodynamic applications. Dr. Dianne K. Newman, Geological and Planetary Sciences, California Institut...

DuPont part of science-based consortium receiving U.S. Dept. of Energy 'Bio-Refinery' grant

...hnologies for the rapid discovery, development and optimization of novel proteins and microorganisms. The National Renewable Energy Laboratory is world-renowned for its expertise in biomass conversion. Professor Bruce Dale, a biomass expert from Michigan State University, will address life cycle analysis. Deer...

European scholars support development of germ line modification

...ded. Developments such as the DNA chip will enable optimization of choice of vector for somatic gene modification. It also makes Pre-implantation Genetic Diagnosis possible for many conditions, and will make it possible to test for the correct insertion /modification of genes within the context of IGM. A form of ...

Computer program reveals optimum microstructure for new materials

...nd why they are built as they are. "Using rigorous optimization techniques, we are now in a position to test some of the basic tenets of biology," Torquato said. "Are there elements of biology -- perhaps subsystems within an organism or cell -- that are optimized in any sense?" Torquato and co-authors Sangil Hyun...

Falling prey to machines

... the book. But evolving solutions for well-defined optimization problems is distinctly different than synthesizing something as opened-ended as consciousness or freewill. According to Holland, the problem with developing artificial intelligence through things like genetic algorithms is that researchers don't yet ...

Hormones, sand & terrorism

...rojects yielding better predictions of impacts and optimization of mining locations. CONTACT: Paul A. Work, South Carolina Sea Grant Researcher, Georgia Tech Regional Engineering Program, Phone: (912) 644-7753; Email: paul.work@gtrep.gatech.edu Timely Publication from Delaware Sea Grant on Port Security The ...

Achillion and UMBC collaboration identifies new class of agents with potential to treat HIV

...ummers' team to identify additional candidates for optimization and clinical testing." The discovery is all the more remarkable considering the youth of Summers' research team at UMBC, a group of two graduate and two undergraduate students. The team includes biochemistry graduate student Chun Tang; sixteen-year-o...

Researchers design and build first artificial protein

...ackbone conformation. After repeating the sequence optimization and structure prediction steps 10 times, they arrived at a protein sequence and structure predicted to have lower energy than naturally occurring proteins in the same size range. The result was a 93-amino acid protein structure they called Top7. "It...

Scientists report first sequencing of environmental genome

...is recombination may be a strategy for maintaining optimization in the event of perturbations in the environment. The observation helps us understand the factors that shape evolution and drive development of new species." Banfield said that the community genome technique worked in this situation because the domin...

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