Researchers Find Possible New Route to Making Cancer Cells Vulnerable
...d light on a new mechanism that canbe exploited to overcome drug resistance in cancer cells." The researchers tested their ideas using common baker's yeast as a modelorganism, because basically the same multidrug resistance pump (MDR) isfound in yeast, animals and people, Heitman said. The ...Salvage Gene Is At The Root Of Many Mutations
...cur because mutations permit precancerous cells to overcome the geneticdefenses against unlimited cell proliferation and migration." The Rochester researchers believe the findings could open a major new avenue of cancer prevention. People withgenetic predispositions to cancer could be given drugs to knoc...Gene Discovery Could Overcome Aluminum Barrier To Higher Wheat Yields Worldwide
...els. This is a first in soybean breeding and will overcome the problem of decreasing protein levels as seed yield increases. [Contact: Richard F. Wilson, <a href="http://sun.ars-grin.gov/ars/SoAtlantic/Raleigh/snfr/">Soybean and Nitrogen Fixation Research Laboratory, Raleigh, N.C. (919) 515-3171] U...Newly Discovered Human Protein Provides Important Target For Cancer Therapy
...svanishingly small," Dr. Weinberg says. To overcome this problem, the Weinberg lab developed a genetic ployusing yeast. They created novel yeast mutants with specific defects in theirability to replicate telomeres. Shortly thereafter, both the Whiteheadresearchers and a team led by Drs. Joachim Lin...Epic Of Evolution Conference Brings Science And Religion Together November 12-14
...Museum."A major objective of this conference is to overcome the public misconceptionthat science and religion are inherently in conflict over evolution," saysAudrey Chapman, director of the AAAS Program of Dialogue Between Science andReligion. "This is a pioneering effort to discover how to combine good scie...Dendritic Cell Therapy For The Treatment Of Cancer
...owever, Dr Austyn suggests that thisproblem may be overcome by using dendritic cells in conjunction with other typesof immunotherapy. Dendritic cell therapy alone may also prove useful for patients at high risk ofrecurrence after a primary tumour has been removed by surgery, or for healthypeople at risk of de...Pitt Researchers Construct Novel Delivery System For Gene Therapy Of Liver Disorders
...mmunecells. Non-viral vectors, like the RCRs, can overcome these problems, but inthe past, these types of vectors have proven only marginally effective intransferring their cargo of genes to target cells. "The role of RCRs is to transport substances in the body. Because theyexcel at this task, we ...Memorial Sloan-Kettering Investigators
...he response to retinoic acid as well as prevent or overcome the lossof response to this drug. More broadly, it opens up an exciting new pathway forthe treatment of many types of cancers." One such cancer might be non-Hodgkin's lymphoma, a disease that strikesfar more patients than APL: More than 50,00...Microsurgery Made More Accurate With Virtual Measuring Tool
...res in different depth planes (z-axis) remains. To overcome this difficulty, we have created a prototype virtual tape measure (VTM) for the operating microscope, by employing the Augmented Reality technique of combining stereo- video images with stereo-computer graphics. The VTM is intended to enable surgeons...Nitrate Reductase: A Magical Enzyme?
...at we want to find out." In an attempt to overcome the scarcity factor, Campbell and otherresearch groups like his are working to develop a process that will result in"recombinant" expression of the nitrate reductase gene and will providescientists with the large amounts of the material they need for...Change In HIV May Precipitate AIDS
... body (in vivo). The NICHD scientists have overcome this limitation by culturing andinfecting pieces of tonsil, which is composed largely of lymphoid tissue,obtained from tonsillectomies. With this advance, they have helped illuminateone of the central questions of HIV pathology--what triggers the eve...UPMC Researchers Report On Gene Therapy Advances
...ter insertion. "Although there remain hurdles to overcome for the gene treatment of muscledamage, this study indicates that we may soon provide growth factors for muscleregeneration through gene therapy, accelerating, and even improving musclehealing post-injury" predicted Dr. Huard. Osteogenesis imperfect...U-M Engineers Win Army Grant To Build Artificial Eye
...llenges are many, but I believe we will be able to overcome them andpave the way for other applications with the optoelectronic sensor," he said. In addition to Bhattacharya, the following U-M College of Engineering facultyare involved in the project: Profs. George Haddad, Clark Nguyen, and Sang Lee. The gro...Research Into Cockroach Behavior Could Lead To Better Baits
...is experiments, he starved roaches so hunger would overcome their natural first instinct toward curiosity. He found they exited their hiding places, sampled the air, then moved steadily toward the food source, ignoring all visual cues. "It's clear they're responding to something in the air, the odor," McCoy s...Interdisciplinary Method Offers New Way To Study Ribozymes
...rom the toolboxes of chemistry and biology,we have overcome this problem," Lu said. "Our method combinesthe high thiophilicity of mercury with the selective placing of phosphorothioatesto increase the affinity at the active site and permit spectroscopic analysis." In the April 29 issue of the Journal of the...Birds Sing The 'Story Of Their Lives,' Theorize Duke Biologists
...lyze a male's song quality tojudge how well he has overcome the stress of early life and how effective a matehe will be. The researchers, Associate Professor of Zoology Steve Nowicki andresearch associates Susan Peters and Jeffrey Podos, discussed their theory in anarticle in the latest (dated Februar...Breakthrough: Scientists Create 3-D Map Of Cell Membrane Ion Pump At Near Atomic Resolution
..." the researchers used a detergent-likecompound to overcome a stubborn technical difficulty. The problem was thatunlike most other proteins, cell membrane proteins are embedded in a naturalgreasy substance that makes growing crystals of them nearly impossible. By a clever strategy, Scarborough succeed...New Vancomycin Structure May Point To Path For Overcoming Antibiotic Resistance
...y development of new, more effective drugsthat can overcome bacterial resistance." Loll and Axelsen were the first to describe the structure of vancomycinlast year, publishing those results in the February 19, 1997, issue of theJournal of the American Chemical Society -- just before the vancomycin-re...Vaccine Kills Spreading Cancer In Animal Model
...entists currently are working on new approaches to overcome thisproblem, including direct administration of the E7 gene with a gene gun,so-called "naked" DNA vaccination. Plans also are being made for an initialhuman trial of the current vaccine. Other study authors were Wu, Edwin Chang, Ken-Yu Lin, ...New Gene Therapy Technique Results In Efficient Gene Delivery
...d. Harvard Medical School researchers seem to have overcome thisobstacle by building these weighty, less pugnacious viruses a bridge. The new technique links the virus and target cells by a bridgeconsisting of two proteins?the growth factor EGF and the receptor for a proteinfound on the avian leukosis...