Brain Protein "Rescues" Neurons From Atrophy
...ingenstein and McKnight foundations. In a separate paper in the October issue of Neuron, the scientists reported the first steps in deciphering the intercellular chemical "language" that neurotrophins use in fostering brain cell growth. Graduate student Kimberley McAllister, Lo and Katz reported finding th...Bacterial Toxin Surprises Scientists
...[like digestive enzymes]." In a paper published in the March 1996 issue of the Journal of General Physiology , the researchers mapped out a rough structure of two conformations of colicin Ia, a toxin produced by some strains of E. coli bacteria to kill co...Enzyme's "Magic" May Hold Key to Anticancer and Antimicrobial Drugs
... Watson and Crick, 1953 In the seminal paper quoted above, Drs. James D. Watson and Fra... the reaction, by a different "gate." The PNAS paper supports the "two-gate" theory. The researchers used two approaches: to lock close...New Cancer Switch Discovered By Duke Medical Center Pharmacologists
...achinery of cancer cells to kill them. In a second paper in the October issue of Molecular and Cellular Bio... students David Cortez and Lisa Kadlec. In a third paper in the Nov. 21 Proceedings of the National Academy of Sciences, Mikhail Gishizky of SUGEN Inc. along...New 'Twist' In Proteins Offers Possible Route To Improved Antibiotics
...s had not yet been determined. The Science paper reported that Roderick's X-ray crystallography of theenzyme revealed that it consists of three identical subunits that fit togetherto form the functioning enzyme. Each subunit consists of a novel "left-handed"beta helix at the end called the NH2-ter...Duke Geologists Explore Alternative Way To Measure Ice Age Sea Bottom Temperatures
...rofessor Paul Baker, another author of the Science paper and a supervising geochemist. "The temperature of the deep water through time is very poorly understood because there hasn't been any unambiguous paleothermometer developed." The researchers cautioned that more work needs to be done before the calciu...International Research Team Clones New Skin Cancer Gene
...2 said Allen Bale, M.D., senior author of the Cell paper and director of the Cancer Genetics Program at the Yale Cancer Center. The discovery paves the way for novel approaches to preventing and treating basal cell carcinoma, according to David J. Leffell, M.D., associate professor of dermatology at the Ya...Cornell Researchers Precisely Date Wood From Ancient Tomb In Turkey
... with charcoal samples, are long colored strips of paper depicting various chronologies. One orange strip on the wall runs from circa 500 B.C. to 50 A.D.; a blue strip pasted below begins at 362 A.D. and stretches around the corner to the present. Such simple displays belie the sophisticated technologies...Surprising Protein Movement Seen In Cells
...ed in the research. The findings are detailed in a paper published Aug. 9 in thejournal Science. And the rapid protein motion can be viewed in avideo clip to be posted on the Internet, at the followingaddress: http://www.uchc.edu/htterasaki/flip.html The researchers were able to study the movement of pro...Harvard, Duke Researchers Discover 'Off-switch' Inside Human Cells
...logy at Harvard University. Otherco-authors of the paper are Duke graduate and medical student Timothy Fields,and Harvard graduate student Timothy Hunt. The research was supported bythe American Cancer Society and the National Science Foundation. RGS10, belongs to a family of "regulators of G protein sign...Discovery Of Cell Sites May Shed Light On How Bodily Systems Interact
...king with the endocrinesystem." Co-authors of the paper were Kelley, Richard A. French and James F. Zacharyof the U. of I. College of Veterinary Medicine, and researchers from INRA-INSERM(the equivalent of the USDA and NIH in France) and Hoffman LaRoche, an internationalpharmaceutical company....KU Researcher Eyes The Rain Forest Through The Trees
... some officials were hoping to cash in on pulp and paper needs by planting the exotic trees. However, the plan didn't bear fruit. "The exotic species of trees need a lot more work and expense to keep them healthy," she said. "So it isn't any more cost-effective to grow them in that region than it would be ...Two Long-sought Diabetes Gene Found
...t did not pinpoint the precise gene. This landmark paper was the first time genetic techniques had been used to determine the chromosomal location of a gene that could cause diabetes. It allowed the researchers to successfully predict which children from the family would eventually develop diabetes. Since ...Scientists Discover Smallest Frog
... biologist from Pennsylvania State University in a paper published in the December issue of the journal Copeia . The one-centimeter-long frog also is the smallest of the tetrapods, a grouping that includes all animals with backbones except fishes. Scientists S. Blair Hedges of Penn State...Researchers Find How Disease-resistant Plants Recognize Bacteria
...e same issue of Science contains a second research paper that addresses different aspects of the recognition mechanism, which was written by researchers from the laboratory of Brian Staskawicz, professor of plant biology at the University of California, Berkeley. The papers represent major breakthroughs in...New Finding Suggests "HATs" Are Key To Gene Activation Puzzle
... that they had cloned and sequenced a HAT; a later paper in Nature explained how theenzyme modifieshistones. The Rochester researchers were joined by Xiang-Jiao Yang, Tetsuro Kokubo, and Yoshihiro Nakatani at the NIH.Researchers at Cambridge University in England, Penn State, and the Wistar Institut...Proteins Interacting With RNA And DNA Are Surprisingly Similar
... samepoints along one of their coils. A scientific paper detailing the findings was published in theJanuary issueof a British science journal, Nature Structural Biology. The discovery suggests that the RNA-binding protein, called L11,could be anancient, ancestral form of other proteins that bind to DNA and...Moving DNA Molecules With Magnetic Tweezers
...o has played with a magnet. If you place a sheetof paper over a steel button, then hold the magnet on top of thepaper, you can move the button without touching it. Wirtz'smagnets are three sets of coiled copper wire, each connected to apower source. The coils are positioned to produce electromagneticfields...Bottom-up Ecological Processes Better For Clear Waters, Study Finds
...overextrapolation ofthe data," according to a 1992 paper in the journal Limnology and Oceanographyby Rita D...al biomass,"Brett said. The science meta-analysis paper by Brett and Goldman also casts doubt uponthe universal nature of a popular model developed by Lauri......nal biologyis coming of age, according to a review paper in the Jan. 17 issue of theweekly journal Science...our of the most noted scientists in the field, the paper reviewsthe role of powerful computational tools in studying ecology, genetics andevolution, infectio...