Belgian researchers explore revolutionary approach to angiogenesis
...roying them by anti-angiogenic drugs constitutes a paradigm shift in approach to angiogenesis," Dr. Feron told a news briefing today (Thursday 30 September) at the EORTC-NCI-AACR[2] Symposium on Molecular Targets and Cancer Therapeutics. The key to the ability of tumour arterioles to contract lies with endot...Alaska scientists find Arctic tundra yields surprising carbon loss
...tions than is caused by fossil fuel burning. "The paradigm is that decomposers (microbes) are always limited by carbon availability and almost never limited by nitrogen availability, but this project suggests that we don't understand decomposition as well as we thought we did. Better understanding of decompo...Breaking new ground in germ cell guidance
...odel can be validated, it may well represent a new paradigm for explaining the function of LPPs in developmental processes from axon growth and patterning to extraembryonic vasculogenesis....New paper in Science introduces revolutionary new paradigm for fishery management
.... This significant advancement would overturn the paradigm of maximizing the catch of individual species that has prevailed for more than half a century. National legislation to promote the use of ecosystem-based fishery management is expected by September in the U.S. Senate and House of Representatives. The...Other highlights in the July 7 JNCI
...olecule kinase inhibitors, pose challenges to this paradigm because they can achieve their maximum effect at levels lower than the maximum tolerated dose. In a new study, Wendy R. Parulekar, M.D., and Elizabeth A. Eisenhauer, M.D., of Queen's University in Kingston, Ontario, reviewed endpoints used in 60 pub...New study confirms process leading to disorder causing male characteristics in women
...ontrols. To test this supposition, they employed a paradigm of sequential GnRH-receptor antagonist administration to suppress endogenous LH concentrations, and intermittent (pulse-like) infusions of physiological amounts of recombinant human LH (rhLH) to stimulate ovarian steroidogenesis. A New Study The au...Two billion vulnerable to floods by 2050; number expected to double or more in two generations
... from the perspective of human security requires a paradigm shift in thinking towards disaster prevention and preparedness, says Dr. Bogardi. "Instead of starting with the focus on natural hazards and their quantification, the assessment and ranking of the vulnerability of affected groups should serve...Fox Chase Cancer Center's Alfred Knudson Jr. named 2004 Kyoto Prize winner
...Alto Research Center in the 1960s and '70s led the paradigm shift away from mainframe computing and opened the door for the personal computer revolution; and Prof. Jurgen Habermas, a philosopher at the University of Frankfurt and permanent visiting professor at Northwestern University, whose communicat...Scientists receive awards, give lectures at the ASBMB/IUBMB meeting
...o-animal" research strategy expected to serve as a paradigm for future structural biology studies, he is now involved in research that will ultimately be expressed in a knockout/transgenic mouse model to provide the first in vivo structure-function correlations for the costimulatory molecules. Dr. Sunney I. ...Stuart Lipton honored with Jung Prize for Medicine
...oratory, which has led to the development of a new paradigm for treating stroke and neurodegenerative diseases based on "neuroprotection", or protecting the brain from cell death. In most neurodegenerative diseases, the brain is attacked and nerve cells wither and die by a variety of overactive signaling pat...Findings redefine mechanism of action of RNA helicase enzymes
...hanism of action of RNA helicases and constitute a paradigm shift in assessing roles of these enzymes in virtually all biological processes that involve RNA." In an accompanying perspective article, Patrick Linder of the Department of Microbiology and Molecular Medicine, University of Geneva, Switzerland, wr...Other highlights in the May 5 JNCI
... of several chemopreventive agents and construct a paradigm for apoptosis as a target for cancer chemoprevention. Contact: Laura Sussman, Communications Office, M.D. Anderson Cancer Center, 713-745-2457, lsussman@mdanderson.org Also in the May 5 JNCI: Small Gene Changes in Some Leukemia Patients May Explain...Animal studies show promise treating severe chronic pain
...ht seem like a radical departure from the standard paradigm of blocking protein receptors or desensitizing them to control pain, but our laboratory data, obtained from cells in a dish, was so compelling that we thought it just might work." As reported this month, Karai et al. performed a series of experiments...UCSD finds genetic time bomb in heart that leads to heart failure in some patients
... may have uncovered, conceptually, the mechanistic paradigm for this important form of human heart failure," Chien said. "Further work is ongoing to determine whether it may hold to be true for other forms of congenital heart disease, and to see if blocking the activity of the BMP-10 growth factor might have ...Surprises found in gene variation associated with schizophrenia
...se we have human models of it, it can be used as a paradigm to understand those other gene defects," Philibert added. The type of evolutionary advantage -- resistance to disease -- that the UI team saw in the HOPA polymorphism also can be seen in a polymorphism linked to sickle cell anemia. In that con...Scientists question reports of massive ant supercolonies in California and Europe
... the last 100 years. Challenging the supercolony paradigm is more than an academic exercise, says Stanford biologist Deborah M. Gordon. Argentine ants have had a major impact in many parts of the world, she says, and understanding how they reproduce and colonize is essential if scientists hope to develop re...Combination therapy drives cancer into remission
...f Cold Spring Harbor Laboratory, establishes a new paradigm for overcoming chemotherapy resistance in many forms of cancer. Rational Target Selection and an Off-the-Shelf Chemotherapeutic "One-Two Punch" for Lymphoma and Other Cancers Pre-cancerous cells can be eliminated from the body by a natural self-de...University of Pittsburgh Medical Center acquires biotechnology firm Rheogene Inc.
...oSwitch technology brings to the marketplace a new paradigm for the development of cell-based therapeutic products, in which any therapeutic gene can be delivered to and regulated for the patient. Therapeutic gene expression is most effectively managed by modifying the interaction between an inducer drug and ...Translational repression in germline development
...e Xenopus African clawed frog, indicating that the paradigm of translational repression through the 5'/3' interactions is conserved across species. Nakamura next intends to look into the means by which the repressor effects of the eIF4E-Cup-Bruno complex are alleviated at the appropriate developmental stage......thematicians, and physicists has uncovered a novel paradigm for cell communication that provides new insights into the complex question of how the body determines where organs are placed. The study focused on a fundamental question: how the body tells left from right. Although humans look fairly symmetric on...