Genetic screening recommended to detect new neurodegenerative disorder in men over age 50
... Paul Hagerman and UC Davis assistant professor of pathology Claudia Greco, showed accumulations of abnormal cellular material in the form of inclusion bodies in the nuclei of brain cells, (specifically neurons and astrocytes) throughout the cortex and brainstem regions. The greatest densities were found in th...Simple sugars make cell walls like steel
...plications," said Nick Carpita, a botany and plant pathology professor. "These could include controlling crop plant size and shape, improving desirable textural properties of fruits and vegetables, and enhancing nutritional fibers in plant cell walls without changing other plant structural factors." Before t...JCI Table of Contents, January 15 2004
... of paraplegin activity, which may account for the pathology observed in Spg7-/- mice. A timely therapeutic int... gangliosides GM2 and GA2 also plays a role in the pathology of this disease. The authors found increased levels of serum anti-ganglioside autoantibodies and IgG...OXiGENE launches significant expansion of its R&D program in ophthalmology
...ficant improvement in visual acuity and underlying pathology seen in this first patient, together with our current understanding of the safety profile of CA4P gleaned from our numerous ongoing oncology and ophthalmology studies, has stimulated us to expand our development strategy. We now plan to broaden our ...First animal model for pancreatic cancer may lead to early detection of disease
...king treatment nearly impossible.Understanding the pathology of how pancreatic cancer develops is essentialto finding a way to prevent or treat this disease. Drs. Sunil R. Hingoraniand David A. Tuveson from the Abramson Family Cancer Research Institute atthe University of Pennsylvania genetically engineered mi...Plant immune system's 'take two aspirin' gene, offers hope for disease control
...g to another BTI researcher and professor of plant pathology at Cornell, Gregory B. Martin. In a 2001 research article, he suggested that some molecular mechanisms involved in innate immunity in mammalian and insect systems "are remarkably similar to the molecular mechanisms underlying plant disease-resistance...Plant pathologists express need for plant pathology-related microbial culture resources
.... While many collections of relevance to plant pathology do exist, there is a need for a comprehensive repo...ns for the preservation of materials used in plant pathology research, said Kevin McCluskey, Research Assistant Professor, Department of Microbiology at the Univ...Link between alcohol consumption and muscle damage in females
... New Study In an attempt to better understand the pathology induced by alcohol on a common muscle, a team of researchers has tested their hypotheses to determine if: (1) increases in c-myc mRNA levels also occur in the muscle of rats chronically exposed to alcohol, (2) muscle of female rats is more sensitive...Lab tests can reveal how patients respond to Gleevec
... Christopher Corless, M.D., associate professor of pathology in the OHSU School of Medicine and co-investigator in the GIST research. Also study co-investigators are Brian Druker, M.D., JELD-WEN Chair of Leukemia Research at the OHSU Cancer Institute and an investigator of the Howard Hughes Medical Institu...Researchers show absence of key oxygen-sensing molecule leads to developmental defects
...e study included Dr. Michael Bennett, professor of pathology and pediatrics; Dr. Kan Ding, postdoctoral researcher in internal medicine; Yavuz Oktay, student research assistant in the Integrative Biology Graduate Program; Dr. James Richardson, professor of pathology; Dr. Marzia Scortegagna, postdoctoral resear...Protein biomarkers accurately and quickly diagnose ALS, find Pittsburgh researchers
...s," said Dr. Bowser, who is associate professor of pathology and director of the ALS Tissue Bank at the University of Pittsburgh School of Medicine. "A panel of biomarkers would not only be useful in a more rapid diagnosis of ALS, but also would be a valuable tool to evaluate drug efficacy in clinical trials. ...Anti-platelet drug blocks bone metastases in mice
...cher, M.D., assistant professor of medicine and of pathology and immunology. "These metastatic tumors can be very painful and weaken the bone to the point of fracture." Weilbaecher, the principal investigator in the new study, cautions that while it might be possible to use ML464 or other anti-platelet drugs t...Breast cancer can be reversed in laboratory mice, scientists report
...d conference director Robert Cardiff, professor of pathology at UC Davis School of Medicine and Medical Center and an author of the research. "Our findings suggest paths forward that may help us alter the biological path of breast cancer and more successfully treat -- and even potentially prevent -- this cance...Study of the brain wins Eppendorf/Science prize
...achinery might well play a fundamental role in the pathology of neurodegenerative disorders, including Parkinson's and Alzheimer's diseases. Ehlers grew up in Grand Island, Neb., and earned his bachelor's degree from the California Institute of Technology. He received his M.D. and Ph.D. degrees from the Johns ...Major new finding on genetics of Parkinson's disease zeroes in on activity of alpha synuclein
...nd sporadic, or typical, Parkinson's disease. The pathology of typical Parkinson's disease is similar to the pathology in this family, they note, and previous work from the group and others has suggested that the amount...Gene-expression atlas will provide new direction for brain and spinal-cord studies
...in most cases, it's hard to know where the primary pathology lies -- which cells are responsible for contributing to the primary effects in the disease. Based on data provided by this atlas, investigators can express a mutant protein that causes a human disease in each of the cell types implicated in the disea...NCI awards $7.6 million to prostate cancer research collaboration
...ide biostatistics, animal and tissue cultures, and pathology and laboratory support. Dr. Chung notes that an important goal of the three collaborative projects is to discover relevant genes that may "turn on or turn off" during the making of prostate cancer cells and their subsequent metastasis to bone. "...University of Pittsburgh scientist honored for major accomplishment in cancer research
...ITTSBURGH, Oct. 26 Yuan Chang, M.D., professor of pathology at the University of Pittsburgh School of Medicine, has been awarded the Paul Marks Prize for Cancer Research by Memorial Sloan-Kettering Cancer Center for her work investigating Kaposi's sarcoma-associated herpesvirus (KSHV), the most recently disco...Common genetic damages in non-dividing cells lead to the creation of mutant proteins
...search were Bernard Weiss, PhD, Emory professor of pathology and laboratory medicine, Zara A. Doddridge, PhD, Emory postdoctoral fellow, and Ho Jin You, MD, PhD, from the Department of Pharmacology at Chosun University Medical School in the Republic of Korea....Embryonic pathway critical to growth of digestive tract tumors
... David Berman, M.D., Ph.D., assistant professor of pathology at Hopkins. "It's been about three and a half months since we stopped the cyclopamine, and still the tumors haven't returned." Unfortunately, cyclopamine is unlikely to be useful for patients because there just isn't enough of it, so the search is on...