Tag: "pathology" at biology news

In potentially important discovery, scientists find two forms of genetic material chromatin

...ll biologist and a report author. "For example, in pathology laboratories, differences in chromatin shape and s...y, are Drs. Peter L. Nagy and Michael L. Cleary of pathology and Dr. Patrick O. Brown of biochemistry. "If the DNA from a single human chromosome were stret...

Study shows molecular analysis of early breast cancer lesions may be key to choosing best treatment

...e to classify tumors." Sgroi is director of breast pathology at MGH and is an assistant professor of Pathology ...icroarray technology. "By combining the molecular pathology expertise at MGH with the advanced molecular analysis capabilities of Arcturus, we were able to obta...

Muscle-repair defect underlies two muscular dystrophies

... mice aged, they developed the same kind of muscle pathology found in humans with LGMD2B and MM. However, the researchers studies indicated that the knockout mice were otherwise normal in terms of the muscle proteins known as the dystrophin-glycoprotein complex (DGC), which provides the structural support to t...

A new mechanism that triggers autoimmune disease

...expected," said Kenneth S. K. Tung, a professor of pathology and microbiology at U.Va. "This suggests that autoimmune disease, in addition to a genetic influence, also has an environmental and non-genetic influence. It is really a new paradigm, a new way of thinking about autoimmune disease." Tung and h...

Scientists report discovery of cancer-causing gene in childhood kidney tumor

... check-up. As part of the exam, Fisher checked the pathology report on the patient's tumor, expecting to find t...at a TFEB mutation was linked to the cancer." The pathology report, produced by the study's lead pathologist and co-author Sara Vargas, MD, of Children's Hospit...

Wake Forest scientists develop colony of mice that fight off virulent cancer

...aid Zheng Cui, M.D., Ph.D., associate professor of pathology at Wake Forest University Baptist Medical Center a...romising," said Mark Willingham, MD., professor of pathology and a collaborator. "Our hope is that, some day, this will have an impact on human cancer."...

Technique brings immune-based therapies closer to reality

...ncers," says Jonathan Schneck, Ph.D., professor of pathology and medicine at the Johns Hopkins School of Medici...hor Mathias Oelke, Ph.D., a postdoctoral fellow in pathology at Johns Hopkins. "Many patients simply can't provide the number of dendritic cells needed to get a ...

Scientists identify molecular link between estrogen receptors and invasive growth in breast cancer

...atory of Paul A. Wade, PhD, assistant professor of pathology and laboratory medicine in Emory University School...icine. Lead author was Naoyuki Fujita, PhD, Emory pathology postdoctoral fellow, and other investigators included Emory pathologists David L. Jaye, MD, Masahiro...

Five studies look at risks of differing particulate matter, including exposures on 9/11

...ty and a postdoctoral student in the environmental pathology program at the University of North Carolina at Chapel Hill. Dr. Calderon-Garciduenas described her research in urban air pollution and brain damage as part of an American Society of Investigative Pathology symposium on negative health effects of inha...

Research shows cocaine 'reward' picture more complicated than scientists thought

...UNC's Dr. Oliver Smithies, Excellence professor of pathology and laboratory medicine, Caron created genetically altered mice that lacked two of the transporters, one for dopamine and the other for norepinephrine. Such designer animals, dubbed "knock-out mice," have proven invaluable for studying the activity o...

Over-the-counter pain relievers effective in protecting against breast cancer

...r diagnoses were confirmed by WHI physicians using pathology reports. Average follow-up was 43 months. Even after adjusting for demographics and several potential risk factors, the observed effects of long-term use of NSAIDs in reducing breast cancer risk remained stable. The annual incidence of breast cance...

The structure behind the switch

...," notes Michael Lieber, M.D., Ph.D., professor of pathology and biochemistry and the study's principal investigator. "And yet, the DNA mechanism for how a cell switches from producing one class to producing another has remained a mystery for almost 20 years." The typical antibody molecule is shaped like the l...

Stem cells contribute to tissue regeneration in mice with ALS

...tudy methods may be transferable to studies of ALS pathology in humans, though much more research with animal subjects will be required," concluded Corti. Jasper Daube, MD, chair of the AAN Task Force on Animals in Research and a neurologist who sees many patients with ALS, was encouraged by the study's findin...

New immune-boosting cancer treatment shows promise

...tely decrease in these patients, it was clear from pathology studies that tumor cells were being killed and being replaced by these inflammatory T cells." According to Allison, in the ovarian cancer patients, the studies showed an increase in the bloodstream of a marker molecule indicating that the cancer cell...

Novel molecule may contribute to intestinal health

...hor Susan Gilfillan, Ph.D., research instructor in pathology and immunology at the School of Medicine. Our findings suggest that this molecule may play a fundamental role in gut immunology. When a virus enters the body, proteins called antigens appear on the surface of cells and alert the immune system to infe...

Gene mutation exacerbates eye defect in inherited glaucoma

... albino mice lacking Cyp1b1 appeared to show worse pathology than pigmented mice. A series of genetic crosses of various mice by Libby and his colleagues produced strains of mice whose only difference was the presence or absence of pigmentation. The researchers ultimately pinpointed the key modifier of severit...

Researchers identify new gene mutation in glaucoma

... albino mice lacking Cyp1b1 appeared to show worse pathology than pigmented mice. A series of genetic crosses of various mice by Libby and his colleagues produced strains of mice whose only difference was the presence or absence of pigmentation. The researchers ultimately pinpointed the key modifier of severit...

New mouse virus may help scientists better understand cruise ship epidemics

...er Herbert W. Virgin IV, M.D., Ph.D., professor of pathology and immunology and associate professor of molecular microbiology. "This new mouse virus will for the first time allow us to study this important class of human pathogens." Virgin and colleagues discovered the virus in a strain of immune-deficient mic...

Drug tested for HIV prevention in Baltimore

... says J. Brooks Jackson, M.D., M.B.A., director of pathology and leader of the study. "A combination of drugs is used to treat HIV infection, but we want to see if long-term, low doses of one of these drugs can prevent new HIV infections in people at high risk. HIV infection rates are fairly steady in the Unit...

Cell Transplant Society holds 6th International Congress in Atlanta March 2-5

...tribute to Paul E. Lacy, MD, PhD, retired chair of pathology at Washington University School of Medicine, who is recognized for developing the first experimental model for transplanting islet cells. Collin Weber, MD, professor of surgery at Emory University School of Medicine and president of the Cell Trans...

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