A red flag for lethal prostate cancer
...ssion," says Chinnaiyan, an assistant professor of pathology and urology in the U-M Medical School. EZH2 is on...culty member, who is now an associate professor of pathology at Brigham and Women's Hospital and director of the Dana Farber Harvard Cancer Center Tissue Microar...University of Pittsburgh Cancer Institute discovers proteins linked to colon cancer
... senior author and associate professor of urology, pathology and pharmacology at the University of Pittsburgh and co-director, Prostate and Urologic Cancer Program, UPCI and colleagues analyzed cancerous tissue resulting from colon cancer that had spread to the liver the most common site for colon cancer to r...Alzheimer's disease may originate in the brain's white matter
...r: "Only if the full extent of Alzheimer's disease pathology is known will present attempts to intervene in the progression of the disease have any reasonable chance of success."...Gene therapy treats first disease affecting multiple organ systems in a large animal
...s throughout the body," said Haskins, professor of pathology and medical genetics at Penn. "Previous applications of gene therapy in dogs have targeted disorders affecting a single bodily function, such as vision or blood clotting. Like many diseases that we might eventually like to treat with gene therapy, ...UC researchers confirm coast redwood and Douglas fir as hosts for sudden oak death pathogen
...s," said David Rizzo, associate professor of plant pathology at UC Davis. The research was a collaboration between the laboratories of Rizzo and Matteo Garbelotto, adjunct assistant professor of ecosystem science and a cooperative extension specialist at UC Berkeley's College of Natural Resources. "We see a wh...Smithies wins top award from Massry Foundation
...California at Los Angeles. Excellence professor of pathology and laboratory medicine at UNC, Smithies won the honor for gene targeting, a technique he pioneered. He and his colleagues have developed mice with mutations that model human genetic diseases such as cystic fibrosis, some forms of anemia, high blood ...Twenty years of monkey research boosts AIDS knowledge
...said Murray Gardner, professor emeritus of medical pathology at the UC Davis Center for Comparative Medicine. About 300 researchers from around the world will reflect on those past achievements and discuss new data when they gather Sept. 8-11 in Monterey, Calif., for the 20th Annual Symposium on Nonhuman Prima...New predictor of heart disease risk found
...eart disease," said Ishwarlal Jialal, professor of pathology and director of the Laboratory for Athersclerosis and Metabolic Research at UC Davis School of Medicine and Medical Center. "The attachment of white blood cells and their entry into the vessel wall are early events that lead to fatty streaks or early...Researchers discover how herpes tricks the immune system
...eader Herbert W. Virgin, M.D., Ph.D., professor of pathology and immunology and of molecular microbiology. "By targeting this viral protein or by manipulating the complement system, perhaps someday we can develop better treatments for herpes virus infections." The complement system consists of about 20 differe...Mice provide insight into bone metabolism disorders
...says F. Patrick Ross, Ph.D., research professor of pathology and immunology at the School of Medicine. Ross led the study, which appears online in Nature Medicine on Aug. 5 and will be published in the September issue of the journal. The first authors were Sunao Takeshita, Ph.D., and Noriyuki Namba, Ph.D., bo...New predictive marker found for prostate and colon cancer
...icine; Mark A. Rubin, M.D., associate professor of pathology and surgery; Ikuko F. Mizukami, Ph.D., research associate; and graduate students Teresa S. Hyun and Priti D. Kumar. ...Researchers identify gene involved in autoimmune disease
...atments, said Dr. Kenneth S. K. Tung, professor of pathology at the University of Virginia and co-investigator of the study. "Utilizing a mouse model to study autoimmune disease will have a definite impact on the understanding of human autoimmune disease as genes that cause disease in mice have been found to b...Researchers identify defect that causes rare muscular dystrophies
... in a controlled way, Steven Moore, a professor of pathology at the University of Iowa, studied mice in which the dystroglycan gene was deleted selectively in brain. In these mice, they found a remarkable similarity to both the myd mouse and the patients brain abnormalities. The finding strengthened the grou...Brain reserve capacity and its role in preventing clinical signs of Alzheimer's disease studied
...ase neural reserve and allow the brain to tolerate pathology without manifesting memory loss and other clinical...ly promote the accumulation of Alzheimer's disease pathology in these systems, other risk factors may actually maintain the structural integrity of these systems...Abnormal chemical bonds cause bleeding disorder
...vo, M.D., assistant professor of pediatrics and of pathology and immunology. "The finding should give us a better understanding of how normal platelets function and of the delicate balance that exists between these blood-clotting elements, disturb that balance, and the whole system falls apart." For the past 2...Researchers identify protein linked to tumor invasion
...ior author Alex Toker, Ph.D., of the department of pathology at Beth Israel Deaconess Medical Center (BIDMC) and assistant professor at Harvard Medical School. "But once the cancer has metastasized, it becomes intractable." In fact, the goal of early cancer detection is to remove the primary carcinoma before ...Mimicking a human disease in mice
...ed incorrectly. Doctors know very little about the pathology of the disease. However, one characteristic is that some brain cells show abnormal changes. Affected mature oligodendrocytes, the cells that form the isolating outer layer surrounding nerve fibers, produce a small protein called alpha-synuclein. They...Protein complex found to regulate first step in human blood clotting
...rcher, Elaine Bearer, M.D., associate professor of pathology and laboratory medicine. "Understanding these molecular events could lead to better treatments for abnormal clotting." Roughly 80 percent of strokes are caused by atypical clots that block blood flow. Bearer and colleagues found that Arp2/3 complex i...Key powerhouse enzyme linked to cancer development
...ematology and professor of medicine, cell biology, pathology and oncology. Proteins made by the PRDX3 gene, known to be overexpressed in breast cancer, chew up or reduce oxidants, called peroxides entering the cell. Hopkins investigators used a scanning method to "skip" through pieces of the PRDX3 gene and ...Potential therapy reported for children, adults with end-stage liver disease
...in animal studies in preventing a cascade of brain pathology that appears to both cause and signal the final an... of the earmarks of the ammonia toxicity and brain pathology that characterize end-stage acute and chronic liver disease. In 1992, he developed the first and onl...