A liking for sweets, combined with novelty seeking, may predict alcoholism
...e two traits may allow us to better understand the pathophysiology and genetics of alcoholism. Kampov concurs. If confirmed by further research, these findings may lead to the development of a simple test that will allow clinicians to assess the risk of developing alcoholism of any given individual early in his o...JCI Table of Contents, 15 July 2004
...these genetic defects play a role in the molecular pathophysiology of the disease. A case in point is Marfan syndrome. Marfan syndrome is a dominant connective tissue disorder whose main characteristics are aortic aneurysm and dissection, ocular lens dislocation, and long bone overgrowth. In 1991, a mutation in a...DFG establishes first German-Sino Research Training Group
...s will work in the fields of molecular biology and pathophysiology of the lungs at the interface between basic and clinical research. In cooperation with the Norwegian universities in Bergen and Oslo, the universities of Heidelberg and Mannheim will work on the subject "Development and Application of Intelligent Det...New findings are a window into the late stages of 'Lou Gehrig's' disease
...ide a window into the late stages of the molecular pathophysiology of human neurodegeneration....JCI Table of Contents, January 15 2004
...ies. TITLE: Possible role of autoantibodies in the pathophysiology of GM2 gangliosidoses AUTHOR CONTACT: Shoji Yamanaka Yokohama City University School of Medicine, Yokohama, Japan. Phone: 81-45-787-2586 Fax: 81-45-786-0191 E-mail: shojiy@med.yokohama-cu.ac.jp View the PDF of this article at: https://www.the-jci...JCI table of contents, January 2, 2004
...ut has never before been considered as part of the pathophysiology of ischemic stroke in the context of diabetes. TITLE: Estrogen stimulates microglia and brain recovery from hypoxia-ischemia in normoglycemic but not diabetic female mice AUTHOR CONTACT: Susan J. Vannucci Morgan Stanley Children's Hospital of New Yor...Chronic pain: treatment, rehabilitation, and quality of life
...tory time changes provide further insight into the pathophysiology of ventilatory abnormalities and shortness of breath during exercise. Functional electrical therapy improves arm, hand recovery after stroke, pg # 443 Paper describes a randomized single-blinded study of the effects of Functional Electrical Therapy...Host response to anthrax lethal toxin suggests some current treatment strategies are inappropriate
... make clear that anthrax patients exhibit a unique pathophysiology and should not be considered to have generic shock analogous to Gram-negative sepsis". Prince continues "exactly how the lethal factor produces such profound tissue hypoxia, what metabolic processes are affected in the liver and elsewhere, and how th...... make clear that anthrax patients exhibit a unique pathophysiology and should not be considered to have generic shock analogous to Gram-negative sepsis". Prince continues "exactly how the lethal factor produces such profound tissue hypoxia, what metabolic processes are affected in the liver and elsewhere, and how th...A sex-specific gene for depression
...ers and shed light on important differences in the pathophysiology of mood disorders in men and women. Alterations in CREB1 expression have been reported in the brains of patients who died with major depression, those of animal models of major depression and related disorders, and in the brains of animals treated ...Pitt researchers find genes for depression; Play role in mood disorders, shorter lifespan
...t there are important differences in the molecular pathophysiology of mood disorders in men and women, or in the mechanisms that determine resistance to stressful stimuli. They may also help explain the vulnerability of women to depression during times of significant hormonal fluctuation including puberty, menstrual...Fibroleukin at fault in viral hepatitis
...dicate a critical role for Fgl2/fibroleukin in the pathophysiology of viral hepatitis and suggest that inhibition of this prothrombinase may be important for the treatment of inflammatory diseases not only of the liver but also of other tissues....JCI table of contents, July 1 2003
...dicate a critical role for Fgl2/fibroleukin in the pathophysiology of viral hepatitis and suggest that inhibition of this prothrombinase may be important for the treatment of inflammatory diseases not only of the liver but also of other tissues. TITLE: The Fgl2/fibroleukin prothrombinase contributes to immunological...'Man's best friend' may be even better
... the friendly beagle dog -- closely resembles the pathophysiology for human allergic rhinitis. This discovery enables the use of experimental techniques similar to those used for the assessment of human nasal passages and permits other, related experiments. The authors of "Canine Model of Nasal Congestion and Alle...Inherited gene may place some at higher risk of post-traumatic injury seizures
...thout the gene. The finding sheds new light on the pathophysiology of post-traumatic epilepsy and may lead to new therapies that could prevent brain-injury patients from developing seizures, said Dr. Ramon Diaz-Arrastia, associate professor of neurology at UT Southwestern and lead author of the paper. "Post-traumati...JCI Table of Contents, April 1, 2003
...m atopic individualsand has been implicated in the pathophysiology of atopic diseases.Interested in the regulation of this receptor on DCs, Thomas Bieber andcolleagues have examined the expression of the different components of thereceptor during DC maturation (pages 10471056). While FceRIapha is presentat high leve...The elusive preeclampsia factor discovered?
...of Clinical Investigationnow shed new light on the pathophysiology of this disease. In the firstarticle, S. Ananth Karumanchi and colleagues at Beth Israel DeaconessMedical Center in Boston report that preeclampsia is associated withelevated levels of a protein called sFlt1. To test whether sFlt1 isresponsible for t...New potential therapy for sickle cell disease
...50 years, research is still unraveling the complex pathophysiology of sickle-cell disease. The defective gene results in production of abnormal hemoglobin, the oxygen-carrying protein in red blood cells. In low-oxygen conditions, the defective hemoglobin molecules bind together, causing the cell's shape to distort. ...Coat-color gene mutation mimics neurodegeneration of prion diseases
...a biochemical activity that could help explain the pathophysiology of the neurodegeneration that we were seeing," said Barsh. Further experiments revealed evidence that the Attractin protein -- which is a receptor-like protein -- might somehow act as a regulator of Mahogunin , both in the pigmentation and neural ...Conference focuses on practical strategies for preventing and treating obesity
...-pharmcological options for weight management, the pathophysiology of body composition and energy balance, advances in obesity clinical research, the role that ethnicity, culture and socioeconomic factors play in obesity, and developing a weight control program for your practice. The conference is presented by the I...