Tag: "pathway" at biology news
Key to Triplet Repeat Brain Diseases Open Door For New Way To Understand, Treat Genetic Diseases"
...an hypothesize that binding of GAPDH may start the pathway
oferrant protein interactions, Strittmatter said he can't yet define the cascadeof events that produces the disorders. "The brain is entirely dependenton glucose metabolism, and this is a protein that is important in that pathway,"he said. "But becau...
Core Spins Faster Than Earth, Scientists Find
...ually becoming more closelyaligned with the actual pathway
traveled by the waves betweenSouth Sandwich and Al...re's fast axis had moved away from theseismic wave pathway
between Kermadec and Norway over that period. Theresearch was funded by the National Science Foundat...
Discovery Could Help Understand Breast-Cancer Therapies
...priategenes or growth factors along the biological pathway
in the body. Her labalso has developed models of tamoxifen-resistant human cells in an attemptto understand how resistance develops. "Understanding these pathways should provide insight that should helpin drug development for therapies that are more...
Northwestern Scientists Discover How Herpes Simplex Virus Infects Cells
...ol have discovered a human protein that provides a pathway
forherpes simplex virus to infect lymphocytes, important cells of the immunesystem. This human protein is not only the first "portal of entry" forherpes simplex virus to be identified, but is also a previously unknownmember of an important family of ...
Two Long-sought Diabetes Gene Found
...-alpha and HNF-4-alpha are members of a regulatory pathway
first identified in cells of the liver but present... including those of the kidney and intestine. This pathway
was not considered to be important in the insulin-secreting cells of the pancreas and thus was overl...
Researchers Find How Disease-resistant Plants Recognize Bacteria
...vidence that indicated that the type III secretion pathway
also operated in plants, and Martin recognized that this pathway
would explain why the kinase proteins are found in the plant cell cytoplasm, instead of on the cell ...
New Study Shows Steps Leading To Colon Cancer
... drugs which might turn off or block the signaling pathway
that leads to tumors," he said. Fruit flies are far more important in biology and medicine than most people realize, Peifer said. "Two years ago, the Nobel Prize in medicine and physiology went to three scientists who showed us that essentially t...
NIH Team Discovers Endocrine Tumor Gene
...ene could indicate the presence of an entirely new pathway
for the control of cell growth," says Dr. Collins. MEN1 is expressed throughout the body, not just in the endocrine glands as scientists might have predicted based on the endocrine tumors characteristic of the disease. The researchers say they wouldn...
Scientists Bridge Gap In Cell Communication
...lopment. By revealing the terminus of the pathway
by which cells send and receive messages, the find...-Madison. "The universe of genes regulated by this pathway
is very large. I would guess hundreds of genes." "The missing link," explained Laughon, "ha...
Resistance To Leptin Contributes To Obesity
...n the Aymice may result from a defect in the nerve pathway
activated by leptin,"Friedman says. "In NZO mice, a decrease in the transport of leptin intothe cerebrospinal fluid may cause the obesity." Friedman, Halaas and Denton's coauthors include: Naseem Fidahusein,B.S., at Rockefeller; Carol Boozer...
New Gene May Intensify Breast Cancer Growth
...d a new genethat is pivotal to a crucial metabolic pathway
linked to the growth andprogression of human breast cancer. The gene appears to be expressed atabnormally high levels in tumor cells of most breast cancer patients, more thanhalf of cases examined so far. The researchers report their findings in theA...
Altered Genes, Altered Metabolism--Longer Life?
...or insulin is available, the daf-2 geneactivates a pathway
that puts the organism into a hibernating state. A decreasein metabolism has been observed in calorically restricted rats which have anextended lifespan, suggesting that this mechanism in humans may have thepotential for slowing down aging. The Nati...
Discovery Of Genetic Pathways May Provide New Ways To Combat Candida Infections
...Dr. Fink. "Our study also shows that this genetic pathway
is a common theme among fungal pathogens and so ma...da's ability to filament and that inactivating one pathway
is not enough to stop filamentation. Inactivating both pathways, on the other hand, renders Candida...
Two-Pronged Attack On Immune System Cells Engineered By HIV Gene vpr: Effects Markedly Reversed By Antisteroid Compound RU-486
...sized that Vpr might act through thesame molecular pathway
-- binding to the same receptors -- as those drugs.Glucocorticoids are used as chemotherapeutic agents against some cancers andautoimmune disorders, but are also known to inhibit cytokine production and toinduce cell death in lymphocytes, the categor...
Testosterone And Working Memory; Epilepsy And Schizophrenia; Toxins And Neuron Death; Oregon Researchers Present Findings At Society For Neuroscience
... circadian system, but found the specific neuronal pathway
throughwhich orphanin acts. "This could lead to some important clinical applications,"says Allen. "If we know the receptor site where orphanin works on the circadiansystem, we may be able to use that information to come up with new ways toregulate sl...
Recombinant Protein Immunizes Mice, Promises New Strategy Against Infection And Cancer
... deliver viral proteins to the right immune system pathway
and elicit a CTLresponse. The fusion technology can also be used against cancer cells. Microbial stress proteins could be introduced into tumor cells to act as redflags that attract a CTL immune response," says Dr. Young. The work reported inthe PN...
Green Tea Ingredient Can Kill Cancer Cells
...hly ordered and well-regulated signal transduction pathway
that says, 'You must commit suicide (programmed cell death) or I am going to kill you.' The cells then decide that instead of being murdered, they will commit suicide," said Mukhtar. He feels that this finding leads investigators to a greater unders...
Genetic "Short Circuit" Leads To Cleft Palate
...ent molecules are present in humans, and a similar pathway
may be responsible for human cleft palate. Howeve...amilies and racial groups. We have identified one pathway
that accounts for steroid-induced cleft palate in mice, and provides some promising targets to focus...
Memorial Sloan-Kettering Investigators
...is drug. More broadly, it opens up an exciting new pathway
forthe treatment of many types of cancers." One such cancer might be non-Hodgkin's lymphoma, a disease that strikesfar more patients than APL: More than 50,000 people in the United States arediagnosed with non-Hodgkin's lymphoma each year. Mu...
Gene Therapy Enables Transplantation Without Immunosuppressive Drugs
... In fact, earlier research has shown that if the pathway
for thecostimulatory signal is blocked at the time of foreign antigen presentation --at the time of surgery and in the period immediately thereafter, in this case --then the T cells become permanently tolerant of the new tissue. It is thislearned tol...
1 2 3 4 5 6 7 8 9 10