Brain Protein "Rescues" Neurons From Atrophy
...s had not yet opened, and thus, whose brain visual pathways had not yet fully developed. The scientists kept one eye of the infant ferrets closed, which normally results in atrophy of neurons in the brain region serving that eye, compared to the neurons serving the open eye. However, when the "closed-eye" neu...New Cancer Switch Discovered By Duke Medical Center Pharmacologists
..." Pendergast said. "One is that there are multiple pathways to activate ras. And the other is that we can separate the pathways for anti-apoptotic and transforming activity. Ras appears to be necessary, but not sufficient for th...Ocean Sediments Contain Record of Past Vegetation Fires in Africa
...he core lies below several large-scale circulation pathways originating in Africa. Says Sancetta, "Verardo's work is important because he has uncovered a record of burning that goes beyond historical records, so we can study natural burning before human influence." This in turn will help scientists d...Discovery Could Help Understand Breast-Cancer Therapies
...and how resistance develops. "Understanding these pathways should provide insight that should helpin drug development for therapies that are more tissue selective,"she said. "These studies are of enormous importance for the effective,long-term treatment of breast cancer."...'BirdSource' Website For Citizen-Science Data
... comprehensive data on the distribution, migratory pathways and population trends for North American birds," said Audubon President John Flicker. "This partnership is a perfect marriage of Cornell's high-tech computer capabilities, the Lab of Ornithology's citizen-science team and Audubon's thousands of volu...Scientists Bridge Gap In Cell Communication
...signal." The mapping of the communication pathways between cells is a fundamental quest in modern bio...seases caused by malfunctioning genes or disrupted pathways of communication. Communication -- or miscommunication -- between cells is the basis for ma...Discovery Of Genetic Pathways May Provide New Ways To Combat Candida Infections
...r, the scientists report that two parallel genetic pathways account for Candida's ability to filament and that...ida. When challenged by Candida strains with both pathways knocked out, macrophages emerged victorious. This was good news to researchers, but the real test wo...Regulator Of Fat Thermostat Found
... piece in anunfinished jigsaw puzzle depicting the pathways regulating body weight."This one piece of the puzzle should lead to other areas worthy of examination,"he says. ### Note: For more information, refer to: Dagogo-Jack, Samuel, et. al., "RobustLeptin Secretory Responses to Dexamethasone in Obese Subje...ACS Aids Cornell Vet School Cancer Research
...d Sarcoma." The Oswald study examines mutations in pathways used by growth-factor relay signals from the outside of cells to the cell nuclei, a process that underlies several forms of cancer, including leukemia and breast cancer. The study focuses on one protein, Cdc42Hs, that is a "biological switch" in gro...Fruit Flies May Shed Light On Cocaine Addiction
...es, they hope toreveal the genetic and biochemical pathways involved in cocaine-induced behaviorand addiction. These insights may lead to better treatments for cocaineaddiction. # # # Please mention support for this work from the National Institute of GeneralMedical Sciences (NIGMS), a component of the Nati...USC Study On Soy's Anti-Cancer Effects
...tein could act upon a number of different cellular pathways in the body,its action on the stress response being just one way that the compoundinfluences cancer growth. For the last decade, scientists have used genistein as a biochemical toolbecause of its ability to block an enzyme (tyrosine kinase) importan...Butterfly Wings, Beetle Horns Teach Biologists Basic Lesson In Development's Laws
...w genes are activated, and whattheir sequences and pathways are. And we've lost track of the fact there must bethese larger-scale biochemical regulatory mechanisms that manage size regulationand proportional regulation among body parts. "We hope that this paper will demonstrate that these are approac...Pitt Researchers Find Way To Block Cellular Growth Pathways And Inhibit Tumor Growth
...rom animal models that blocking two cellulargrowth pathways causes tumor cells to die. "We are currently designing aclinical trial for patients with head and neck cancer based on the extremelyencouraging results we have seen in these studies," said Jennifer Grandis, M.D.,co-director of UPCI's Head and Neck Ca......fruitflies--which utilize many of the same genetic pathways as humans--to identifygenes that maintain the balance between cell division and cell death. The workpromises to provide a basic understanding not only of growing tissue, but alsoof developmental disorders, cancer, and neurodegenerative diseases. (N...USGS To Study Young Forests And Streamsides In Western Oregon
... but also aboutestablishing multiple communication pathways among land managers, scientists andthe public. Ultimately this will contribute to better-informed natural resourcedecisions." The USGS center in Corvallis will provide the primary financial support forCFER, as well as research support. The center's r...Hard Hearts: New Discovery Of Bone In Heart Tissue May Explain Valve Disease
...ies ofinvestigations to understand the biochemical pathways that govern the build-upof calcium, and now bone, in heart valves. In late 1997, Mohler and colleaguesfound osteopontin--a protein that makes up the molecular scaffolding to whichcalcium sticks in the formation of bone--in calcified valves. "Finding ...... think now we can put together the spermatogenesis pathways using thesame approach as has been used in yeast."...Research Sheds Light On How Plants Regulate Distribution Of Nutrients
...here. My suspicion is that there are other control pathways that are integrating with this system to communicate information such as water content or nitrogenavailability." Understanding resource distribution in plants, Bush said, may lead tothe ability to manipulate the distribution of carbon to maximize cr......ed, and the flow of information along pathways which are regularily used are strengthened by addition of connections. These modifications of brain circuitries are also believed to underly the mechanisms of learning and forgetting in the mature brain. The d......s of heart failure--tounderstand what molecules or pathways are involved in the formation of heartfailure and why the heart progressively fails until it can no longer function,"Rockman says. xvThe UNC cardiologist and co-authors from Duke University and the Universityof California at San Diego focused on ...