Tag: "pathways" at biology news

Gene triggers stem cell differentiation in the intestine

... these intestinal cells depend on these regulatory pathways to signal them to stop proliferating, understanding those pathways could yield insights into the mechanisms of colon cancers. In the longer term, said Zoghbi, understa...

Enzyme mimetic reduces tissue damage in colitis animal study

...cess, has been shown to contribute to inflammatory pathways and to regulate cytokine release. In addition, M40403 reduced the production of adhesion molecules, intercellular adhesion molecule-1 (ICAM-1) and P-selectin, in the intestinal wall of the animals. These adhesion molecules appear to play a major rol...

Fish may show how nature diversifies

...his method we can ask which genes or developmental pathways nature uses to create a new species. The scientists were able to study the molecular evolution of the threespine stickleback due to its recent evolution since the end of the last Ice Age, which occurred 15,000 years ago. When the giant glaciers m...

Scientists describe structures of protein molecules that enable two-way signaling between cells

...d likely be to stimulate or inhibit the Eph-Ephrin pathways and perhaps accelerate nerve regrowth and regeneration as therapies for brain or spinal-cord injuries. Drs. Dimitar Nikolov and Juha-Pekka Himanen were the structural studys lead researchers in cellular biochemistry and biophysics at Memorial Sloan-K...

Penn team finds 'molecular chaperones' can halt progress of Parkinson's disease in fruit flies and possibly humans

...ddition, the group has found evidence that similar pathways may operate in Parkinsons disease and possibly other neurodegenerative disorders in humans. The findings will be published in the journal Science, as part of its Science Express web site, on Dec. 20. They suggest that activation of molecular chapero...

Scientists identify molecular structure of cancer-related proteins

...ication between receptors on the cells surface and pathways within the cell. Researchers determined the structure of an Eph receptor tyrosine kinase bound to its corresponding ligand molecule called ephrin. Interactions between Eph receptors and their specific ephrins lead to an array of cellular processes, i...

Experimental appetite suppressant affects numerous brain messengers in mice

...disease. While mice are not men, there are common pathways in fundamental activities. "If we can understand the pathway that triggers eating, we may be able to find safe ways to intervene," says Daniel Lane, Ph.D., professor of biological chemistry in the School of Medicine's Institute for Basic Biomedic...

January media highlights-GSA Bulletin

... Control of internal structure and fluid-migration pathways within the Barbados Ridge dcollement zone by strike-slip faulting: Evidence from coherence and three-dimensional seismic amplitude imaging. Christopher G. DiLeonardo,et al. Earth Sciences Board, University of California, Santa Cruz, California 950...

Lehigh scientists believe they have found link between DHEA and central nervous system

... have looked at DHEA's structure, and at metabolic pathways in cells, to determine what effects androgen might have at the genetic level," says Simon. "We are the first lab to demonstrate that DHEA can act to regulate gene function by interacting with androgen receptors, either by itself or after its conversi...

Rutgers wins NIH grants to study how tea consumption, diet are tied to cancer

...to study how diet and nutrition affect the genetic pathways which lead to cancer formation. In addition to the scientists mentioned earlier, participants in the planning grant include other researchers from RutgersUniversity and the University of Medicine and Dentistry of New Jersey, notably professors Khew-...

Research may lead to jump-starting damaged nerve cells

...em back to their proper function using the natural pathways embryonic cells take to become fully functioning nerve cells, Dryer says.Nerve cells, or neurons, connect to each other in complex networks, carrying electrical and chemical signals through the body to other cells, or target tissues, allowing muscles...

Reining in cancer

...different growth factor-driven signal transduction pathways might produce a more significant anti-tumour effect. Treatment using this approach would not be restricted to breast cancer, but could be applied to a range of tumours carrying the target growth factor receptors.** "Target-based agents are becoming a...

Findings link disease specific anitbodies to activation of T cells for the first time

...roup has recently identified a number of potential pathways that may be utilized by lymphocyte derived cytokines in driving the tissue remodeling that occurs in Graves disease. Dr. Smith and his associates have found that fibroblasts from the orbital connective tissue (eye area) differ from fibroblasts found...

Cells on the verge of suicide

...ccording to Steller, there may be other cell death pathways with similar outcomes, but this one is the first to be elucidated in full. "Although the regulation of cell survival and cell death has been studied intensely, in not one case has the precise, step-by-step mechanism by which survival factors suppres...

Tidying up transcription factors

...ls are very disparate in their internal activation pathways but all share a global design: cell surface stimulation by an extracellular protein that activates a latent cytoplasmic factor which upon activation enters the nucleus to function in activating gene transcription." The researchers hope the paper wil...

Inventor of artificial hand sees 'bionic' replacement parts becoming more human

...nd is the first to let a person use existing nerve pathways to control individual computer-driven mechanical fingers. Craelius published an overview of bionics entitled "The Bionic Man - Restoring Mobility," in the international journal "Science," on Feb. 8. Craelius believes "bionic technologies can be ada...

A new route to branching morphogenesis

...rotein kinase C-a. Nickel et al. find that the two pathways can operate in parallel, since HGF enhances this morphological change even in the polycystin-overexpressing cell....

New mouse model enables studies of heart, brain and spinal cord

...(such as PAX-3) by their very nature control large pathways of other genes," Dr. Conway said. "There are lots of different pathways that interact. Other genes do specific things but transcription factors are at the top of the pathwa...

UNC neuroscience center awarded $1.7 million for nerve growth and regeneration studies

...ansduction mediator in the growth factor signaling pathways that apparently makes axons rapidly grow longer and also makes them wider. "We and others have the idea that growth factors are going to be a very important part of axon regeneration," Snider said. "It's our hypothesis that these growth factors actu...

Viral proteins may be associated with human brain tumors, according to findings by Temple researchers

...ssion suggests a potential role for agnoprotein in pathways that control the development of JCV-associated medulloblastomas. According to Khalili, the JC Virus most likely infects humans through the upper respiratory tract and remains in a latent stage in most people throughout their lives, and, in some case...

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