Tag: "pathways" at biology news

Another small cog in the 'hub' of metabolism unraveled

...respiratory chain. The coupled action of these two pathways is a major source of metabolic energy (see Fig. 1).In order to obtain detailed insight into the function of a biological macromolecule such as succinate dehydrogenase, one has to know its three-dimensional structure. However, the structural analysis ...

Researcher finds alternatives to antibiotics for growing chickens

...ounds don't kill microbes but work by blocking the pathways that lead to weight loss. The first is an antibody -- not an antibiotic -- that Cook identified. The antibody binds to the gut peptides, keeping them from causing the birds to lose their appetites. When fed the antibody, chickens retain their app...

Study may help clarify how cells grow

...owth factors. "This is just one of many signaling pathways but we know it's essential for growth," he said. "...triguing that breakdowns in the cellular signaling pathways may be associated with the unbridled cell growth associated with tumors. "What we're most intrigued...

Photoreceptor gene mutations cause degenerative eye disease

...that it might bring to understanding the signaling pathways that determine cell type in the embryonic retina." Right now, researchers do not know how precursor photoreceptors reach their ultimate cell type. "ESCS is interesting in what it might imply for how photoreceptor pattern and fate gets set up in the...

Rate of sound impulses markedly affects ability to perceive volume

...lliculus, located in the midbrain where many audio pathways converge. This processing center is important for sending information upstream to higher brain centers for sound perception, and also downstream for the indirect regulation of hearing sensitivity in the ear, whose role had long been thought to be pa...

Uncovering structure of cellular switch could aid design of cancer-fighting drugs

...dc42, a molecular "switch" that turns on essential pathways in both normal and cancerous cells, and GDI (for guanine nucleotide-dissociation inhibitor), a key regulator of the Cdc42 switch, is reported in the February issue of the journal Cell (vol. 100, pp. 345-356). "Knowing the precise, atom-by-atom str...

Searching for biochemical markers in children of alcoholics

...lism involves alcohol1s ability to activate opioid pathways within the brain." In addition to its predictive qualities, noted Wand, B-E may also be causal in nature. "There is so much evidence now that the endogenous opioid system is involved in the reward for most drugs of abuse, including alcohol. This ...

Bitter taste receptors identified

...ceptors, but there's more work to be done: tracing pathways from receptor cells to the brain, generating "knockout" mice that lack T2R s and studying their taste deficits, and searching for more gustducin-linked receptors....

Drosophila genome sequence completed

...usly to understand the complex signal transduction pathways that regulate cellular processes. "That is where t...been working to understand the signal transduction pathways involved in cancer formation. "The easiest way to understand that would be some kind of a genetic sc...

How a hormonal henchman triggers death

... One pleasant surprise, said Thummel, was that the pathways seemed relatively simple. "We unexpectedly found that the hormone receptor directly regulates transcription of the reaper gene," said Thummel. "It's quite a shallow pathway. We couldn't ask for a simpler circuit." The researchers still face the fa...

Aptosyn™ (exisulind) and other SAANDs target early event in cancer; AACR presentations detail novel apoptotic pathway

...s scientists studied the role of cGMP in apoptosis pathways via cGMP-dependant protein kinase (PKG). "We found that Aptosyn™ activates PKG in colon cancer cells, not directly, but by blocking of cGMP-PDE, an enzyme which degrades cGMP. Cyclic GMP is a known activator of PKG," said W. Joseph Thompson,...

Nerve protein shown crucial to sensations of pain from heat, injury

Probing the molecular pathways of pain, scientists have shown that a proteinlodged on the surface of many sensory nerves triggers the nerves to fire painsignals when it is exposed to Death Valley-like heat or the fiery properties ofpeppery food. The research is the first to demons...

Matrisian named Vanderbilt's first chair of cancer biology

...ancer Biology Department will be the communication pathways between cells and their environment, Matrisian said. "The cues that cells take from the environment are often disrupted in cancer, so it provides an excellent place to target therapy and prevention strategies," Matrisian said. "The goal is to re-esta...

Cloning reverses aging in cow cells, a milestone in medical research

...de again) is partially based on impaired signaling pathways between the sensing sites at the cell membrane and the targets in the nucleus. Francis is an associate investigator at the Lankenau Institute for Medical Research and often collaborates with Cristofalo. Her research examines the mechanism of action o...

Researchers seek clues to help newborns with abnormal lungs

...es affecting specific functional and developmental pathways of lung." She also hopes to discover some novel genes by using this approach. Chinoy is presenting her work titled, "Differential Lung Gene Expression in Experimental Congenital Diaphragmatic Hernia," at The American Thoracic Society 2000, the 96th...

Warman named to Hughes Institute

...hritis, specifically to delineate the proteins and pathways that maintain human joints and their potential for treating heritable and acquired forms of the disease. This is the second year in a row that a CWRU researcher has received this award. Last year, Dennis Templeton, associate professor of pathology, ...

Welch Award honors 2 for unlocking nature's secrets

...hat nature uses to make B12. He notes that the two pathways evolved two billion years apart, depending on whether or not an organism required oxygen. Currently his diverse lab is looking to apply the lessons learned from his B12 research to make other products, such as the cancer treatment taxol. He also rece...

Genomics project aims to create a "virtual plant"

... a complete "wiring diagram" of all the biological pathways of Arabidopsis . "Ultimately, we hope to create a 'clickable plant,'" said Chory. "We want to be able to go to our computers and click on a cell type and understand all the protein-protein interactions. "We'd love, for instance, to see a four-dim...

Genetic method has promise for assessing environmental cleanup

.... "Of all the genes that we know about and all the pathways that we know about, this is a very important one and it is probably the dominant one," says Nies, who sees the technique as a potential new way to monitor the progress of cleanup efforts at contaminated sites. "Suppose you took a soil sample at a sit...

UF researchers find painless electrical stimulus helps restore hand movement for stroke patients

...he wrist or finger muscles, or encourage alternate pathways to form. "Many patients were able to move better than when they came in, and it was real dramatic for a few folks," Cauraugh said. "It opened up that avenue of 'Wow, maybe I really can do something with that limb." Stroke survivor Leslie McClellan...

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