Study reveals surprising 'remodeling' property of gene regulation process
...he same in mammalian cells." The study potentially paves the way for scientists to understand how chromosomal remodeling influences gene expression and regulation in human diseases such as cancer, Strahl said. "This is such a fundamental observation about the genome, but nobody had ever made it before," he...Scientists identify cells that lead to retinoblastoma
...y in the June issue of Cancer Cell, this discovery paves the way for developing new treatments for retinoblastoma that target these first cancerous cells, thereby avoiding the difficult side effects that patients suffer from treatments such as radiation therapy and chemotherapy. "From the first cancerous c...Announcement of the chicken genome sequence and genome variation maps
... chicken genome sequence and genome variation maps paves the way to the understanding of chicken as a model organism for research on vertebrate evolution and human health, and to the improvement of poultry breeding and food safety....Steroid-coated DNA represents new approach to gene delivery
...titute for Medicine and Engineering. "The concept paves the way to coupling therapeutic gene delivery with a pharamacological agent, an approach that mitigates some of the drawbacks to the gene-delivery techniques in use now." Currently there are two basic approaches to delivering therapeutic genes: non...Natural killer cellers are made, not born
...ed cells is not present at birth. This new insight paves the road to changes in bone marrow and stem cell transplant procedures and will enable scientists to pursue research into activating natural killer cells to help the body fight emerging infections and tumors. In two separate papers in the February i...Rutgers scientists discover protein in brain affects learning and memory
...utgers, The State University of New Jersey. "This paves the way to designing new drugs that could target this protein molecule." Proteins or the genes that code for them have become the targets of choice for developing precisely focused, effective new drug therapies one of the outcomes of the many revela...JCI Table of Contents, January 15 2004
...eport and how understanding this binding mechanism paves the way for rational drug design. He comments "There are now well over a 1000 proteins known to contain Bateman domains. For many of these proteins we can now begin to hypothesize about how they are regulated by adenosyl metabolites." TITLE: CBS doma...Discovery of brain disorder gene paves way for genetic test
...lusters of blood vessels in the brain. The finding paves the way for a new genetic test for the rare, familial disease, which typically lies dormant in patients for decades before its potentially devastating symptoms appear, said the researchers. The vessel lesions in the brain can cause seizures, severe ...New way to lock DNA-slicing enzyme onto chromosomes could lead to novel anti-cancer drugs
...in that part of the twisted molecule. This in turn paves the way for other enzymes to unravel the DNA and either decode a specific gene or duplicate the entire chromosome. Normally, Top 1 moves along the DNA, clipping the strand as it goes, while the other enzymes follow behind, unraveling the DNA. If the...Soldier or worker what do the genes say?
...one of the first molecular studies on termites, it paves the way for investigations into how termite larvae can develop into workers, soldiers or reproductive adults depending on the colony's needs. The eastern subterranean termite, Reticulitermes flavipes, exists in colonies, whose members share work and...New principle guides memory dynamics
...exist between different animals, including humans, paves the way to the possibility that certain drugs found to be effective in eliminating memories in animals will also work on humans. Studies on humans, however, are yet to be conducted. The results of the study were published today in the scientific jour...Relapse or remission? Pharmacogenomics draws the fine line
... not necessarily equal the whole. This information paves the way for identifying new molecular targets to see why some cells are resistant or why others are cured, and Evans is doing ongoing work with patients to develop more custom-tailored care for children with ALL. "I think using gene expression profil...MITs smart surface switches properties reversibly
...ties in response to an external stimulus. The work paves the way for systems that could, for example, release or absorb cells and chemicals from surfaces on demand. In the Jan. 17 issue of Science, the researchers describe an example of their new approach in which they engineered a surface that can ch...Cancer killing gene found by Dartmouth researchers
...mechanism that sets a cell death program in motion paves the way for developing new cancer-killing drugs, according to Ethan Dmitrovsky, professor and chair of pharmacology and toxicology. He headed the research team that included Sutisak Kitareewan, Ian Pitha-Rowe, Sarah Freemantle and David Sekula. Reti...Researchers discover gene causing deadly infantile form of genetic kidney disease
...unctional understanding of how PKD progresses, and paves the way for gene testing, more conclusive diagnosis, and treatments to retard development of the disease. Identifying the causative gene is a major step forward as the basic defect and progression of the disease can now be studied, said Peter C. Harr...New study from Mayo Clinic provides insight into male infertility
...rovides valuable insight into male infertility and paves the way for further advancements in infertility. A team of Mayo Clinic researchers led by Jan van Deursen, Ph.D., including Ningling Kang-Decker, Ph.D., George Mantchev, M.D., Subhash Juneja, Ph.D. and Mark McNiven, Ph.D., identified that the Hrb pro...MelTec GmbH announces new technology for High-Throughput Topological Analysis of human cells
... has the potential to become a key technology that paves the way for a more systematic approach to understanding disease pathology and treatment, by looking at how protein networks in cells determine cellular function. We believe that the NCDS can enable researchers to simultaneously identify and prioritiz...NICHD funded researchers first to genetically modify non human primate
...HD Director Duane Alexander, M.D. "The technology paves the way for developing new models for testing treatments for a variety of diseases in a more relevant way than is currently possible." Although scientists have often inserted genes into other animals, they have lacked the technical means to introduce...Skin and hair spring from the same stem cells, researchers find
... in the center, for wound repair." The work also paves the way for designing effective skin cancer treatment, by explaining why skin tumors that are produced for the purpose of research frequently originate in the upper follicle. "In addition to wanting to target stem cells in the bulge for skin cancer...Last unidentified sport fish in North America gets a scientific name
...e sport-fishing industry, Burgess said, because it paves the way for conservation efforts to begin. Shoal bass face many threats including dams, human population sprawl and the introduction of non-native fish species, he said. "Largemouth bass are the primary species for sport fishing in freshwater here ...