Targeted therapy knocks out pediatric brain cancer in mice
...medulloblastoma, the most common type of malignant pediatric brain tumor. The finding is encouraging in that su... can have overwhelmingly negative side effects for pediatric cancer patients. The research is published in the September issue of Cancer Cell. "Therapy for pedia...OneWorld Health compiles comprehensive state of infectious diarrhea treatments, potential solutions
...rrheal vaccine effort, with particular emphasis on pediatric solutions. The group explored the state of vaccine...lt travelers' market with little consideration for pediatric use. Some vaccines focus on one pathogen, such as rotavirus, although there are multiple causative ...First clinical study of new pediatric croup vaccine shows safety, tolerability in adults
...). This virus is the most common cause of croup, a pediatric respiratory disease that causes almost 30,000 hospitalizations each year and many more emergency room visits. These findings are published in the current issue of Vaccine. Successful development of an effective hPIV-1 vaccine would be significant b...Babies with DiGeorge syndrome saved by immune supression, thymus transplant
...in isolation rooms in Duke Hospital, either on the pediatric floor or at Duke's General Clinical Research Center, funded by the National Center for Research Resources of the National Institutes of Health. Such isolation helps prevent infections from developing in the infant before mature T cells form. So far, ...Clusters of alterations on PIK3CA gene found in brain cancers
...utant PIK3CA gene in a wider spectrum of adult and pediatric brain tumors as well." PIK3CA is part of a family of genes that encode lipid kinases, enzymes that modify fatty molecules and direct cells to grow, change shape and move. Kinases have been the focus of recent drug development strategies, with some tu...OHSU researchers discover possible method for early detection, prevention of premature birth
... and commercialize biomarkers for fetal, maternal, pediatric and adult applications. ...Protective mechanism exploited by tumors may provide new cancer treatment
...been requested by the tumor," says Dr. David Munn, pediatric hematologist-oncologist and lead author on the study published in the July 15 issue of Journal of Clinical Investigation. Now they have shown in an animal model that these normal cells are a type of dendritic cell that was previously ignored by the ...Gene profiles could improve acute leukemia diagnosis and lead to better treatments
... for the major genetic (molecular) subtypes of the pediatric form of this disease and lead to better treatments...t the gene expression signatures identified in the pediatric leukemias could also be used to accurately diagnose the identical form of leukemia when it occurs in...New lower-cost assay system equivalent to flow cytometry for accurate CD4+/CD8+ cell counts
...per patient, making the method suitable for use in pediatric as well as adult patients. The Guava EasyCD4 assay also requires far less reagent per sample, dramatically lowering the overall costs of performing the assay. Moreover, the Guava EasyCD4 and EasyCD8 do not require the dedicated laboratory infrastruc...ALL survivors bear genetic damage from life-saving chemotherapy
...ies genotoxicity." ALL is the most common pediatric malignancy, but many ALL patients respond well to chemotherapeutic interventions. Since the 1960s, the five-year survival rate for children with ALL has increased to almost 80 percent. Patient remission and long-term survival is credited to the devel...Scientists discover molecular target for treatment of T cell acute lymphoblastic leukemia
...hoblastic leukemia (T-ALL) accounts for 10%-15% of pediatric and 25% of adult ALL cases. A gene called TAL1/SCL is frequently activated in T-ALL patients, but exactly how it causes leukemia has not been clear. Dr. Michelle Kelliher, from the Department of Cancer Biology at the University of Massachusetts Medi...Fox Chase Cancer Center's Alfred Knudson Jr. named 2004 Kyoto Prize winner
...or. Knudson is married to Anna T. Meadows, M.D., a pediatric oncologist at Children's Hospital of Philadelphia....Fat cells heal skull defects in mice, Stanford research shows
...d by you," said Lucile Packard Children's Hospital pediatric craniofacial surgeon Michael Longaker, MD. "They are not foreign and they don't express foreign genes. To our knowledge, this is the first time these cells have ever been shown to have a therapeutic effect." Longaker, a professor of surgery at Stanfo...University of Michigan symposium charts course for the future of telemedicine
ANN ARBOR, Mich. A pediatric patient in Marquette, Michigan is being examined by a doctor but the doctor is 365 miles away in Ann Arbor. Elsewhere in Michigan, a mental health patient, his family and psychiatrist are participating in a commitment hearing in the safe, secure envi...University of Pittsburgh receives NIH funding to develop heart assist device for infants
...dustry partners, the Pitt researchers envision the pediatric ventricular assist device (PVAD) to be about the s...it being standard practice for nearly 30 years for pediatric patients of all ages who are in heart failure, its use is associated with a high death rate. Less th...Vanderbilt doctors use Viagra to treat infants with pulmonary hyptertension
... of 6-month-old Hartley Wilson, Don Moore, M.D., a pediatric cardiologist at Vanderbilt Children's Hospital, had to make a difficult decision. Shortly after birth, Hartley had emergency surgery to correct a heart defect known as total anomalous pulmonary venous return. He remained in the hospital for the next ...Comprehensive study: We know little about environmental effects on kids
... involving contributions from more than 40 leading pediatric experts, each of whom wrote about how environmenta...minants that are present, says Gary Myers, M.D., a pediatric neurologist at the University of Rochester Medical Center who was co-author of a supplement paper ti...National Foundation For Cancer Research names UCSD's Webster Cavenee NFCR Fellow
...on transcription factors in normal development and pediatric neoplasms. Since 1991 Cavenee has been Director of the San Diego Branch of the Ludwig Institute for Cancer Research and professor of medicine at the University of California, San Diego School of Medicine, where he is also a member of the Rebecca an...Researchers discover an alternate form for the disease gene associated with Rett syndrome
...inding answers that can ease our struggles." "For pediatric neurologists, the best place to practice medicine is in the lab because that is where we can actually do something that will one day be useful in treating our patients," said Dr. Minassian. "Meanwhile, we see Rett girls in clinics and hold their pare...Gene chips help gauge chemotherapy's effectiveness in adult leukemia patients
..."La Sapienza." "While approximately 70 percent of pediatric patients with T-ALL have excellent long-term response to intensive chemotherapy, adult patients have a much less favorable outcome. Previously, this poor prognosis of adult T-ALL patients had not been attributed to specific genetic events." Sabina Ch...