Belgian researchers explore revolutionary approach to angiogenesis
...rioles to contract lies with endothelin-1 (ET-1) a peptide released in large amounts by many tumour cells, wh...a an endolthelin antagonist in this case a cyclic peptide called BQ123 to target selectively one of the ET receptors, ET-A, that we found was particularly de...Green, leafy spinach may soon power cellphones and laptops
... A new twist in the current work is a membrane of peptide surfactants-similar to the main ingredient in soap...y environment for at least three weeks. "Detergent peptide turned out to be a wonderful material to keep proteins intact on the surface with electronics," Zhan...Chemical signals health of brain cells Symposium
...etylaspartylglutamate, the most abundant mammalian peptide neurotransmitter. The first comprehensive meeting ever held on NAA, the Symposium features presentations by leading investigators and a poster session. The meeting is organized by the National Institute of Mental Health and is co-sponsored by the ...Optimizing protein's 'death domain' halts leukemia in laboratory study
... anti-death molecules, BH3-only proteins contain a peptide subunit, termed "BH3", that is made of amino acids...al staple, Walensky explains, these links held the peptide in its natural coiled configuration. Further experiments confirmed that the stapled BH3 alpha helix ...Molecular staples shape a cancer killer
...essfully inserted non-natural amino acids into the peptide sequence and then performed a chemical reaction th...drocarbon staple overcomes classic shortcomings of peptide therapeutics. As the molecular events that lead to execution and death have become clearer during...Synthesized molecules studied as weapon to stop cell division in cancer cells
...ines biological function. Pin1 works by changing a peptide bond within Cdc25 from the trans shape (a flattened-Z shape) to the cis U-shape and back. This a simple change -- the swing of an arm one way or another to open or close the U results in a large conformation change in a protein. The researchers syn...The first engineering of cell surfaces in living animals
...ion in mice, Bertozzi and her collaborators used a peptide that could be identified by a fluorescing antibody. "The future holds a range of opportunities for using the Staudinger ligation for noninvasive imaging," says Bertozzi. "Phosphine markers might include radiochemicals for detection by positron emiss...JCI table of contents, 2 August, 2004
...ound that an adaptive immune response against this peptide was initiated, and that this was followed by an increase in the production of a natural antibody, called T15/EO6, which also recognizes the lipoprotein breakdown product. Mice treated in such a manner showed reduced atherosclerotic lesion size. The ...Two enzymes key to calorie-burning, Brown research shows
...for about a decade that PC1 and PC2 play a role in peptide processing, we did not know their importance in ac...path through the brain, triggering production of a peptide that sends a fast, strong message to the hypothalamus to burn calories. Those results were published...Study: Mothers turn fearless when peptide level drops
...levels of corticotropin-releasing hormone (CRH), a peptide that acts on the brain to control behavior. ... that received either no dose or a low dose of the peptide displayed the expected behavior. As the levels of CRH increased, the number of attacks and the durat......leptin triggers production of the active form of a peptide MSH in the hypothalamus, the small area in the b...to another part of the hypothalamus, where another peptide is produced and released. This stimulates the pituitary gland, which secretes a hormone that relays ...K-State researcher working to improve alternatives to equine antibiotics
...e able to do is specifically turn on antimicrobial peptide production and other immune response factors that ... direction of Dr. Frank Blecha. "The antimicrobial peptide cloning/sequencing work has been part of my graduate work; the immunomodulation with CpG DNA studies......ins that the cone snail's particular organobromine peptide is in human clinical trials for the treatment of pain. "Sponges and tunicates are great examples of using chemicals for survival," says Gribble. "Being anchored to the reef, they can't swim and they don't have protective shells or teeth, so the...Scientists identify molecular link driving spread of skin cancer
...ans such as the lungs. By introducing a synthetic peptide that mimics one component of this link, the resear... that developed in mice that received no synthetic peptide treatment. By identifying the peptide that inhibits the laminin α5CD44 interaction from prope...Secret behind hard exoskeletons, spreading wings revealed
...s produce another protein, crustacean cardioactive peptide (CCAP)," Honegger said. "We used a molecular probe that would attach to bursicon messenger RNA and an antibody that would work against CCAP. From the reaction, we saw that the same cell was producing both. The molecular probe showed us that we really...Researchers recommend new approach to combat drug-resistant staph infections
... that coating implanted medical devices with a key peptide known as RIP can prevent the occurrence of bacterial colonization, biofilm formation and consequent drug-resistant Staphylococcus aureus infection - a leading cause of illness and death among hospitalized patients. RIP acts by preventing bacterial ce...JCI table of contents, 15 June 2004
...f dominant transplantation tolerance by an altered peptide ligand of the male antigen Dby AUTHOR CONTACT: Paul J. Fairchild University of Oxford, Oxford, United Kingdom. Phone: +44-1865-275606; Fax: +44-1865-275501; E-mail: Paul.Fairchild@path.ox.ac.uk View the PDF of this article at: https://www.the-jci....ADAM: Good enzyme for Alzheimer disease
... increased expression of ADAM10 in mice reduced AB peptide formation, prevented plaque formation, and, from a functional standpoint provided improvement in both long-term potentiation and cognitive impairment. On the other hand, mice lacking ADAM10 had increased number and size of amyloid plaques. The data...JCI table of contents, 17 May 2004
... increased expression of ADAM10 in mice reduced AB peptide formation, prevented plaque formation, and, from a functional standpoint provided improvement in both long-term potentiation and cognitive impairment. On the other hand, mice lacking ADAM10 had increased number and size of amyloid plaques. The data......t are inorganic and possibly even toxic. "These peptide coatings serve as 'Halloween costumes' for the par...ed "wavelength division multiplexing," or WDM. The peptide coating technology could, in principle, color encode biology itself, by "painting" different protein...