Gene May Hold Key To Treating Life-Threatening Cholesterol
...he liver. Mangelsdorf said scientists have found a perfect drug target in LXR-alpha. He plans to look for ways to biochemically design hormonal ligands that can speed metabolism and reduce dietary cholesterol levels in humans. Screening for mutations in LXR-alpha also may help identify inherited defects in c...Scientists Identify Molecular Target For Tuberculosis Drug Treatment
... Infectious Diseases (NIAID). "I think we havethe perfect new tool for developing new drugs against TB." The research was a collaborative project of Dr. Barry's team and NIAID granteeJames M. Musser, M.D., Ph.D., and colleagues at the Baylor College of Medicinein Houston, Texas. Their report appears in the...University At Buffalo Team Discovers How The Cell Nucleus Orchestrates Genetic Processes
BUFFALO, N.Y. -- In a perfect illustration of how structure determines function,researchers at the University at Buffalo have demonstrated how an exquisitelyorganized architecture in the cell nucleus controls precisely when and wheregenetic processes are activated, apparently inf...Computer Simulation To Predict Forest Fires
... trees, undergrowth and very old trees that became perfect tinder for fires. The researchers contend that the large Yellowstone fire of 1988, which burned 800,000 acres, could have been prevented if the policy of letting smaller fires burn to completion had been in place before 1972. The smaller fires woul...Birds Of A Feather: The Physics Of Flocks
...d factor: he imagined that the birds would nothave perfect judgment. At each step, each bird would always have a chance ofmisjudging the proper direction it should move. And because the birds rely oneach other to move in the right direction, this error would spread too, causingthe neighbors to fly slightly...Goats And Spiders Are Working Together To Create A Novel Material
...of what a web has to do, its extremestrength makes perfect sense," he says. The silken threads of the web must benearly invisible to prey and yet be able to bring a fly to a screeching halt. Evolution came up with a two-pronged answer to this problem. First camea rock-solid protein, capable of making......n lovers everywhere are ponderingpurchases of that perfect pumpkin to carve into a grinning or ghoulishjack-o-lantern. But, beware, new microbes are gobbling up those bright orangepumpkins. Researchers reported in the May 1998 issue of the journal Plant Disease that anew disease, called "yellow vine," was a...Supernutrients Mean Super Health for Children
... spinach maynot sound like any child's idea of the perfect meal. But as evidence mounts thatfour supernutrients --vitamin A, iron, omega-3 fatty acids and folic acid -- actas the foundation for a child's good health, concerned parents should considernew ways to make these foods and others like them appetizin...LSU Ag Center Program Focuses On Helping Animals Reproduce; Graduates Assist Humans, As Well
...e mid-1970s, hisprogram, along with others, helped perfect non-surgical techniques fortransferring embryos into surrogate mothers. Their original work was withcattle, but they have since developed procedures for sheep, goats, pigs and,most recently, horses. Another milestone for the program was with...Canine Cancer Survivor Is Pet Therapist Helping Kids With Cancer
... Dani's gentle, easy-going personality made herthe perfect dog for the job, waiting patiently as young chemotherapy patientsbrushed her fur, painted her toenails and dressed her in various outfits. Justfour months into her new duties, however, Dani was to experience what theseyoungsters already knew all too ......ittlenotice of a transplanted organ under the most perfect immunological conditions,say two authors, one a Nobel laureate and the other the "father oftransplantation," in this week's New England Journal of Medicine. Thomas E. Starzl, M.D., Ph.D., professor of surgery and director,University of Pittsbu...... Utah or other high-altitude states to obtain that perfect altitude-livingprescription. Essentially, researchers say that nonresponders usually don'tbenefit from a move. The researchers now aim to fine tune the high-low prescription. Some peopleclassified as nonresponders may respond when training at altitud...Gene Therapy Trial Approved For Rare Anemia
...nts is a bone marrowtransplant from a donor with a perfect tissue match. However, for most patients,a suitabl...t 10 patients for the trial. "Fanconi anemia is a perfect candidate disease for the use of gene therapy,"Walsh says. "What we learn from here can be applied t...Largest Acoustics Meeting In History Expected
...may have something that most human musicians envy: perfect pitch, the ability to recognize the pitch of a particular echo tone in isolation rather than in relationto other tones, which is what most human musicians have to do when they hear musical notes. Sabine Schmidt of the University of Munich ( sabi@zi.......ication of the Rab5 regulated fusion machineryis a perfect model system to study the other Rab-dependent pathways in internalcell transport. After a more detailed characterisation of the molecular playersof the transport route from the cell surface to the endosomes, the same systemwill be extended to investi...Scientists Study Protein's Role In Tumor Development In Fish
...ing your child to daycare," Holzschu says. "It's a perfect time tospread the virus." It's thought that the virus grows over the summer and tumorsbegin to appear in the fall. By spring, the tumors are dying and the infectionis passed to other fish. While the seasonal nature of the tumors is enough to ...Heat-Shock Vaccine Stops Bacteria Dead
...stimulate T-helper cells. "Heat-shock proteins are perfect enhancers of the T-helper cell response,butbecause they are part of autoimmunity -- the body's reaction againstits own components -- no one thought of redirecting their activity to fight anexternal threat such as infection," Cohen says. He conducted ...First North Americans Had Chance To Be Avid Birders
...tem where they are located serves, eventoday, as a perfect vantage point, overlooking the broadening of the BluefishValley, and if it was a rainy day, or a bad blizzard, or a freak snowstorm, theycould have been used as temporary shelters," says Cinq-Mars. The challenge now is to find further hard evidence t...... plants have beenevolving for billions of years to perfect their photosynthetic technique. Bystudying how plants accomplish this remarkable feat, scientists hope to somedayalso develop systems that use light as a power source. Identifying and studyingcharacteristics of the protein's metabolism may someday al......riskelions fittingtogether to make a geometrically perfect arrangement, must take place in lessthan a minute (pentagons are required to make a closed structure, since an arrayof hexagons would be a flat sheet). The researchers find that most of the clathrin molecule is rigid, with the onlyflexibility occurri...