Insights on stroke from the peripheral blood suggest ways to develop markers and therapies
...logy meeting. Dr. Baird says new insights from the peripheral blood into the pathology of stroke and the body's ...ally throughout the ongoing stroke. A few drops of peripheral blood provide complete information on DNA, the switching on and off of genes, and the proteins that ...Animal studies show promise treating severe chronic pain
...ly kill these neurons. Because nerve cells in the peripheral nervous system first transmit their signals to the...g therapeutic scenario: The cell bodies of these peripheral neurons bundle together in groups near the spine, called dorsal root ganglia. If RTX were applied ...Closing in on treatment for Charcot-Marie-Tooth disease?
...-Marie-Tooth (CMT) is a hereditary disorder of the peripheral nervous system that strikes 1 person in every 2500...e CMT, the most common hereditary disorder of the peripheral nervous system, leads to debilitation of the muscles in the lower legs, feet and hands. The clinica...Cannabinoids spell relief in colon inflammation
...artin Storr, "this would constrain the activity on peripheral tissues such as the colon and the undesirable effects could be avoided". [BL]...Research points to potential obesity treatment
...to reduce their weight by adding MSH back into the peripheral circulation," says Brennan. "There are MSH receptors in essentially all peripheral tissues, and we know that mice treated with MSH experience an increase in the level of free fatty ac...Muscle-derived cells and gene therapy may cure for post-prostatectomy erectile dysfunction
...rience ED after the procedure due to injury to the peripheral nerves, including the cavernous nerve, located close to the prostate gland. Glial Cell-Derived Neurotrophic Factor (GDNF) Improves Erectile Dysfunction in a Model of Post-Radical Prostatecomy Erectile Dysfunction Abstract 1421 In this study, pres...Tufts University groundbreaking research on caterpillar locomotion
...e central nervous system and how it interacts with peripheral structures such as muscles and cuticles. Second, the unique ability of caterpillars to climb using curved hooks at the tips of the abdominal prolegs is being examined. This gripping is passive but very strong (similar to Velcro hooks) and can be acti...Combination therapy dramatically improves function after spinal cord injury in rats
... and Schwann cells can be grown from patients' own peripheral nerves. The researchers are now planning follow-up studies to confirm their results and to try to learn more about how the triple therapy works, Dr. Bunge says. Their studies might also lead to the development of better drugs to prevent the breakdow...Researchers report major advance in gene therapy technique
...arly, the vein technique can be useful in treating peripheral arterial occlusive disease, often a complication of diabetes. The disorder results in damaged arteries and, frequently, the subsequent amputation of toes. What's more, Wolff says, with refinements the technique has the potential to be used for live...Obesity and hypertension: Two epidemics or one?
...onstrate lower levels of cardiac output and higher peripheral resistance compared with individuals with lower bo...evidence that obesity in humans is associated with peripheral and coronary endothelial dysfunction. There is increasing evidence that obesity is associated wit...Endurance exercise found to be equally effective as diuretics in improving cardiac health
...ayed an absence of symptomatic coronary artery and peripheral arterial diseases, and had no history of myocardial infarction or coronary artery bypass surgery, aortic aneurysm, significant valvular heart disease, congestive heart failure, or noncardiac chronic conditions that might interfere with exercise testi...UNC scientists discover molecular pathway leading to nerve growth and regeneration
...r nerve cells, muscles and the skin. Injury to the peripheral nervous system that portion of the nervous system outside the brain and spinal cord typically results in spontaneous regeneration and repair. However, this is not the case with the spinal cord, where disruption of connections from injury leads to p...RICE gets $1.1m from DOD to study neurofibromatosis
...of five additional genes suffer from tumors in the peripheral nerves that are similar to those found in people w...uct experiments to determine whether NF1 regulates peripheral nerve growth by activating a molecule called protein kinase A. If so, the molecule, known as PKA, mi...Warren Pharmaceuticals publishes results of preclinical evaluation
...rights to the therapeutic areas of the central and peripheral nervous systems. Warren has retained all rights for indications outside of Lundbeck's field, including the eye, cardiovasculature and diabetic complications. Accompanying the Science article is a commentary written by Hannelore Ehrenreich, a neurosci...Brain serotonin enzyme finding might explain psychiatric disorders
... the earlier discovered Tph1 is found primarily in peripheral nerves. The Duke team screened the brains of several mouse strains for the Tph2 gene. To their surprise, said Xiaodong Zhang, Ph.D., lead author of the study, they found not one version of the gene, but two. The two gene variants differed in a single...A pathway to blocking autoimmunity
... NKT cell induction." Dendritic cells wait in peripheral tissue, such as the skin, ready to engulf foreign invaders or dying cells. Once they take up fragments of these cells, known as antigens, they migrate to the lymph nodes, where they prime T cells to mount a specific immune response against that antig...Why some neonates need caffeine
...drop in ventilation involves an acute reduction in peripheral chemoreceptor inputs (i.e., physiological chemodenervation) and thus reflects the strength of the peripheral chemoreceptor drive. The decrease is ultimately followed by an increase in ventilation that is centr...JCI table of contents, 2 August, 2004
...d Outs of Somatostatin Action TITLE: Central and peripheral actions of somatostatin on the growth hormoneIGF-I axis AUTHOR CONTACT: Shlomo Melmed Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA Phone: 310-423-4691; Fax: 310-423-0119; E-mail: melmed@csmc.edu View the PDF of this a...Joslin Diabetes Center launches research section on developmental and stem cell biology
... of diabetes, which include heart disease, stroke, peripheral vascular disease, diabetic retinopathy, kidney disease, nerve damage and birth defects. Many of these complications involve damage to large or small blood vessels. Stem cells show promise repairing blood vessels, so researchers hope that they might b......ock synchronizes independent clocks that reside in peripheral tissues, and every 24 hours, the master clock cycles. This cycling involves the coordinated expression of many genes involved in feedback loops, in which the expression of one gene turns on the expression of a second gene, which turns off the first g...