Cardiovascular system holds a key to circadian clock
...y establishes that blood vessels contain their own peripheral circadian system, similar to clocks in other organs. Also, significantly, it links hormonal and vitamin control for the first time tothe circadian rhythms that control body temperature, sleep and wakefulness ,pain sensitivity, and the response to...Israeli fertility experts call for international chromosome registry
...ho suffer repeated implantation failure after IVF, peripheral blood karyotyping should be part of the routine work-up of the couple. Treatment can then be tailored to fit the individual patient's gynaecological background and the type of chromosomal changes detected. That treatment may be pre-implantation genet...Mouse model of type 2 diabetes
... displayed progressive insulin resistance in their peripheral tissues, and by five weeks of age developed type 2 diabetes. The strain of mice that Dr. Le Roith and colleagues developed fully recapitulates the clinical features of type 2 diabetes, and therefore represents a marked advance in diabetes research. D...Experimental drug decreases age-related blood vessel stiffening
...ering the mean or average pressure by relaxing the peripheral arteries that regulate resistance," says Kass. "ALT-711 appears to be different. It likely acts on the larger vessels that regulate stiffness. This may represent a novel therapeutic approach for patients with arterial stiffening associated with ag...Spinach protein could offer new hope for the blind
...ility to see in dim light and gradually can reduce peripheral vision. Age-related macular degeneration is a disease that affects the center of vision. It rarely leads to blindness but people with the disease have difficulty reading, driving and performing other activities that require fine, sharp straight-ahead......ibrils cause the disease FAP by building up around peripheral nerve and muscle tissue, disrupting their function and leading to numbness and muscle weakness, and -- in advanced cases -- failure of the gastrointestinal tract. The current treatment for FAP is a liver transplant, which replaces the mutant gene wit......utic implications for the treatment of cardiac and peripheral vascular disease, diabetes and recalcitrant wounds. As published in Genes & Development, Dr. Jeffrey Arbeit and colleagues have discovered that the continuous expression of a single gene, HIF-1a, can induce the formation of new blood vessels in mice....Morphine-like drugs could offer relief for amputees
... lidocaine, a drug that predominantly works on the peripheral nervous system, did not relieve phantom pain. Morphine acts on the peripheral and central nervous systems. For the study, Raja and his colleagues studied 32 patients with an ave...Gender differences in cardiovascular regulation during recovery from exercise
...lenges with greater sympathetic stimulation to the peripheral vasculature compared with women, whereas women respond with greater vagally mediated increases in heart rate. Presumably, these mechanisms also play an important role in arterial pressure maintenance when exercise is stopped. Because women exhibit le......red differences in the organization of central and peripheral physiology (i.e., organizational effects). After puberty, exposure to sex steroids serves to transiently activate pre?existing hormonal circuits (i.e., activational effects). In mammals, masculine development is induced by early exposure to testost......results with progenitor cells from the central and peripheral nervous systems of adult mice. The U-M study is available online (see citation and web address at the end of this release). Results include: Over one-third of 3T3 stem cell lines cultured at 20 percent oxygen contained a protein called PPARgamma, ......d out. Each arm appears to contain an independent peripheral nervous system and neural circuitry, which carries...aneuverability of the arms and the capacity of the peripheral nervous system to perceive and process information. The objective of our study is to characterize ...Protein could help rejuvenate oxygen-starved cardiac tissue, heal wounds
...s. The strategy is sought for treating cardiac and peripheral vascular disease, diabetes-damaged tissues and int...emic, tissue such as that associated with diabetic peripheral vascular disease, which can cause chronic leg ulcers that often precipitate amputation. It is being ...Gender issues related to spaceflight: A NASA perspective
...OGY Generally, women have lower blood pressure and peripheral vascular resistance and higher heart rates than me...ases in blood pressure, and less of an increase in peripheral resistance in response to the postflight stand test than their nonpresyncopal counterparts (two wome...Women more susceptible to orthostatic hypotension
...sated for by reflex mechanisms that increase total peripheral resistance (TPR). Otherwise, blood pressure falls, leading to cerebral hypoperfusion and syncope. Reports over several decades support the hypothesis that adequate sympathetic constrictor responses during the assumption of upright posture are critica...Early detection device for exposure to chemical warfare agents being developed
...articular experiment, it seems the answer is yes,' peripheral muscles seem to be more sensitive." This does not surprise him because the highest release rate, turnover rate and breakdown rate for acetylcholine is in the neuromuscular system. As soon as the monkeys show the cold-like signs of increased salivati...Mice point to genetic basis for obsessive grooming
...have a central nervous system defect rather than a peripheral nervous system defect, so Joy Greer began to videotape their behavior and analyze it more closely." Videotaping revealed that Hoxb8 knockout mice groomed themselves more frequently and longer, and spent about twice as much time grooming as normal m...UNC neuroscience center awarded $1.7 million for nerve growth and regeneration studies
...more than 100 years that if you cut a nerve in the peripheral nervous system, it will re-grow. However, if you d...s actually set up the regenerative response in the peripheral nervous system." "And if we are able to understand how these growth factors work, we might be able t...Stanford scientist seeks participants in NASA hypergravity study
... blood to your head, and you will temporarily lose peripheral vision as your visual field begins to dim. The lev... faster. The lights will appear in the passenger`s peripheral visual field and will be moved closer together as the G force increases. The centrifuge will be stop...... laboratory, dendritic cells will be expanded from peripheral blood drawn from a patient or donor. The cells will be separated and then placed in a special container called a bioreactor which contains special nutrients and growth factors (growth promoting proteins) to help the cells proliferate. Tumor cells c...