Genome of potential bioremediation agent sequenced
...roject, scientists also discovered a new bacterial phage (a virus that infects bacteria) that may provide a...that, the genome analysis discovered a lambda-like phage that scientists say "may provide an avenue for genetic manipulation of this group of microbes and al...Natural-born killers enlisted to fight anthrax
...uch, Ph.D., and Daniel Nelson, Ph.D., focused on a phage that specifically infects the biowarfare agent Bac...nthrax. They isolated the enzyme that allows these phage to rupture and escape from the anthrax bacterium and showed that just drops of it can almost instant...First drug developed for widespread use against botulism
...has developed over the past decade called antibody phage display. The scientists first isolated the immune ... surface of viruses that infect bacteria (antibody phage display). Antibodies binding the toxin (and the genes encoding them) were then recovered and charac...Human antibodies against spores found by researchers suggest new tool to detect and treat anthrax
...derway. The researchers found the antibodies using phage display, a method for selecting from billions of a...acteriato create an antibody "library." Since the phage virus displays the antibodies on the surface of the virion, it makes them easy to select for in vitr...New understanding of complex virus nano-machine for cell puncturing and DNA delivery
...he E. coli, thus infected, starts to make only new phage particles and ultimately dies. "Our research described for the first time the structure of phage baseplate proteins and their role in cutting through the host cell wall," said Rossmann....Bacteria's natural foe fights drug-resistant infections
...acteria before infecting their next host. Special phage enzymes, which punch holes in the bacterial cell wall, ensure the phage a rapid exit; without this outer layer of protection the bacteria essentially cannot hold themselves...Tips from the Journals of the American Society for Microbiology: July 2001
...ncreased the ability of both V. vulnificus and its phage to survive simulated gastroinestinal transit and m...urvival of Vibrio vulnificus and Vibrio vulnificus phage in a gastrointestinal model. Applied and Environmental Microbiology, 67: 2895-2902.) BAN ON ANTIBIO...Virus found to carry antibiotic against E. coli
...swer to an old mystery: how Q-beta and other small phage kill bacteria," said Dr. Ry Young, a biochemist i...e important thing is that this is the second small phage which we have found to make a protein antibiotic, and other people in the lab are working on a third...E. coli bacteria may be more useful than you think
...es to and injects its DNA into E. coli. Normally, phage lambda kills bacteria, but a certain mutant lambda...nly to have the DNA degraded. Meanwhile, the empty phage particle, whose long stalk and globular head remind one of a lollipop or lunar lander, remains firml...... solved by Westpheling and her team was that while phage mediated DNA transfer occurs, it was not detected because the phages are extremely virulent and kill cells that receive DNA. The team found a way, however, to remove the phages lethal impact--called superinfection killing--and allow them to serve as ...New therapy uses viruses to attack bacteria
...e results demonstrating the proof of principle for phage therapy of V. vulnificus disease have implications...tudies could offer insight into the application of phage therapy to treat other bacterial infections."...Scientists discover new candidate drugs for treating HIV infection
...Kim lab then used a technology called"mirror-image phage display," to identify a class of compounds that fit thepocket. The technology takes advantage of the fact that all proteins andenzymes can exist in two mirror-image forms. Proteins that occur in nature aremade out of so-called L-amino acids. Their...New drugs target HIV's deep pocket
...sing a techniquethey developed called mirror-image phage display. Proteins can exist in twovarieties, each a mirror image of the other. Natural proteins, made of L-aminoacids, are difficult to use as drugs for numerous reasons, including poorstability and the tendency to trigger an immune response. Using...Cubist Pharmaceuticals Describes New VITA™ Technology For Enabling Genomics For Drug Discovery
...g a new,platform competitive binding assay. Using phage display technology, specificpeptide ligands were identified to approximately 90% of targets tested from adiverse protein target collection. A subset of the peptides was shown to becompetitive inhibitors of the targets. Potent, nM level inhibitors t......ticians' disposal are serogrouping and serotyping, phage typing,antibiograms (antibiotic resistance profiles), plasmid profile and plasmidcompatibility grouping, PFGE (pulsed field gel electrophoresis), FAME (fattyacid methyl ester). analysis. In testing for salmonella infection in cattle,diagnosticians b...