Proteins may help identify patients who will respond better to treatments in certain cancers
...ent of Cancer (EORTC). Molecular marker expression phenotype is an independent prognostic factor for outcome in the chart head and neck cancer randomized trial: Abstract 733 A clinical study of head and neck cancer patients found that molecular markers -- the proteins that distinguish specific tumors -- allowe...Familiarity decides if wolf spider loves 'em or eats 'em
...mmature females were exposed to more than one male phenotype and no female was exposed to more than nine different males. Once the females entered adulthood, the highest proportion of mating occurred with familiar males. "These results clearly demonstrate that a female wolf spider's experience during her penu...Intraepithelial neoplasia may be a leading risk factor for prostate and ovarian cancers
...nuclear chromatin pattern consistent with a second phenotype (visible properties of an organism that are produc...curately detected visually or histologically. The phenotype is also present in women at increased risk for ovarian cancer, suggesting it may represent a pre-mal...Adult alcoholism and attention-deficit hyperactivity disorder are connected
...d impulsiveness. Researchers have found a distinct phenotype or "profile" of adults with co-existing ADHD and a... Experimental Research have identified a distinct phenotype or "profile" of individuals with co-existing ADHD and alcoholism. Although prior studies have sugge...Ingenium publishes biological characterization of first mouse model for kidney stones
...e pair substitutions in the gene, which produces a phenotype closely representing a human disease state," stated Michael C. Nehls, M.D., Ph.D., Chief Executive Officer at Ingenium. "The publication underscores the value of our models for biomedical research in the areas of disease analysis and drug compound an...Nominations sought for professorship by the American Association for Cancer Research
...trointestinal cancer of the microsatellite mutator phenotype pathway. The AACR-NFCR Professorship was established in 2000 in honor of Franklin and Tamara Salisbury, who are best known in the scientific research community for having founded the National Foundation for Cancer Research in 1973. Built on a commitm......siological ability to store fat is due to the same phenotype that causes such trouble in humans: type 2 diabetes. Yet the wild swine seem not to suffer from the usual problems associated with this phenotype. I. Lehr Brisbin of Savannah River Ecology Laboratory and colleague Michael Sturek of the University o...Common nutrients fed to pregnant mice altered their offspring's coat color
...est the hypothesis that early nutrition can affect phenotype through methylation changes," said Jirtle. "Our data confirmed the hypothesis and demonstrated that seemingly innocuous nutrients could have unintended effects, either negative or positive, on our genetic expression." For example, methylation that oc...UT Southwestern researchers define regions of human genes highly prone to mutation
...point mutations. Developing an association between phenotype (the outward, physical manifestation) and genotype (the internally coded, inheritable information) is vital toward understanding and identifying indications of disease. "This discovery can be used to essentially define the likelihood of one gene to ...Scientists develop new RNAi knockdown technology
...Ski-knockdown mice largely recapitulate the mutant phenotype of traditional Ski-knockout mice (in which the Ski gene has been deleted through homologous recombination of embryonic stem cells), suggesting that Dr. Ishii's new system provides an efficient alternative to traditional mouse knockouts in the explora...Scientists discover key gene in artery formation
...mined that the gene responsible for the y10 mutant phenotype was plcg1. The plcg1 protein (Plcg1) is an intracellular signaling molecule found in a number of vertebrate species, including mammals. While previous work implicated Plcg1 in endothelial cell signaling in vitro, a specific requirement for Plcg1 in a...Ingenium publishes groundbreaking research on genetic basis for motor neuron degeneration
... mouse genome. The researchers identified a mouse phenotype that displayed progressive loss of muscle tone and...D research. "The ability to correlate a biological phenotype similar to a human disease state with a specific gene mutation is a powerful approach to discovering...Cloned pigs differ from originals in looks and behavior
...at while cloning creates animals within the normal phenotype the appearance of an organism with respect to a group of characters it increases the variability associated with some traits. "That means that you can't use cloned animals to reduce the size of groups involved in animal experiments," Piedrahita sai...Researchers discover strategy that shields HIV from destruction
...IV-1 that resulted in the neutralization-resistant phenotype and discovered mutations in the viral envelope that caused changes in the attachment of the glycan molecules. The discovery extends a picture of a virus that contains a "silent face" composed of masses of large glycan molecules that obscure its true...Outstanding cancer researchers supported by the American Association for Cancer Research
...trointestinal cancer of the microsatellite mutator phenotype pathway. The AACR and the National Foundation for Cancer Research (NFCR) established this Professorship in 2000 to honor Tamara and Franklin Salisbury, Sr., best known for founding the NFCR in 1973. It recognizes a senior scientist at the level of a...Scientists find 'stem cells' in human breast cancer
...ths. Al-Hajj found a small group of cells, with a phenotype common to all but one of the human tumors in the study, could form new cancers in mice. These cells all expressed a protein marker called CD44, in addition to having either very low levels or no levels of a marker called CD24. "As few as 100 to 200 o...Changes in prevalence of mutations associated with HIV treatment failure
..., resistance data were used to evaluate the median phenotype for 30 mutational patterns associated with resistance to NRTIs. Although further study is needed to determine utility in clinical practice, study investigators believe the technique may be useful to minimize the potential for the rapid selection of ...Coat-color gene mutation mimics neurodegeneration of prion diseases
...air color but also caused neurodegeneration with a phenotype very similar to that caused by the prion diseases." Unlike the prion-produced diseases, the genetic malfunctions in Attractin are not transmissible, do not involve an abnormal prion protein and are not as rapidly lethal, Barsh noted. The Attractin...Presence of certain tumor markers for melanoma could signal best results for vaccine
...ession or loss of MAA are of a selected aggressive phenotype with greater advantage to progress and escape host immunity, thus adversely affecting patients' overall survival," said Dr. Hoon. "These studies suggest that advanced staged patients with melanomas expressing the two or three of the MAAs would benefi...UT Southwestern researchers develop new model for understanding obesity, diabetes
...eficient in either gene displayed a lipid-depleted phenotype pale, skinny, larval-arrested and lacking fat stores, said Graff. "Our hypothesis was that the same or related genes would control fat storage in worms and mammals," Graff said. "We took a couple of the genes thought to be among the most important o...