Researchers Document Transmission Of Protease-Resistant HIV
...HIV anti-retrovirals, the researchers used a novel phenotypic drugsusceptibility assay developed by ViroLogic, I...tient's virus to HIV anti-retrovirals. Virologic's phenotypic analysis showed the patient's virus was resistant to tworeverse transcriptase inhibitors: zidovudine...Ecological Consequences Of Jasmonate-Induced Responses For Plants In Native Populations
...e view that chemical defense can be costly, the phenotypic costs of an induced defense, that is, the fitne...nate-induced responses are examples of adaptive phenotypic plasticity. By timing their germination and growth with the post-fire environment, N. attenuata p...Telomere Loss Spells Trouble for Aging Mice
...ch 5 Cell. "Until now no one has shown the phenotypic effect of telomere loss onthe aging organism," says Lenhard Rudolph, research associate in medicine atDFCI and Harvard Medical School (HMS), and lead author of the study.Telomeres -- nubs of protein and nucleic acids poised at either end of DNAstrand......ions, on a newsystem for genetic cloning that uses phenotypic localization to "interrogate thehuman genome." The BIO '99 meeting is expected to draw an estimated 5,000 biotechnologyindustry leaders from 40 nations, including representatives from many ofWashington's 120 biotechnology and medical-device companies......ility finally ofcharacterizing it at a functional, phenotypic and molecular level." Scientistscan also learn to manipulate the cell in the laboratory, he says, and "willinduce the stem cell to do in the laboratory what it does in the body--self-renew and differentiate to generate a huge number of red blood cell...Cattle, human genomes contain many identical genes
...derstand the molecular genetic basis for the major phenotypic differences among the mammals. This will have enormous scientific and practical significance, particularly in the area of food safety, animal health, and the competitiveness of our domestic beef and dairy industries."...Scientists find gene that fuels 'sexual arms race'
... understanding when and how changes in DNA lead to phenotypic changes," Carroll says. "It is a reconstruction of the evolutionary process at the root of the tree, not the tip, the root." Despite losing their power to sway the romantic interests of female fruit flies, the gender-based pigmentation patterns may s...Phenotype MicroArray(TM) can test thousands of cell properties simultaneously
...he expected changes in cellular response, known as phenotypic changes, associated with genes whose function was ...h cell function test. Incubation and recording of phenotypic data are performed by Biologs OmniLogTM PM System, which uses bioinformatic software to report chang...New mutant mouse repositories established for biomedical researcher community
... By late 2001, the site will also provide detailed phenotypic and genotypic information to researchers intereste...trains as needed; and characterize the genetic and phenotypic makeup of the mutants so that models are validated and may optimally serve as models of human diseas......o fulfill its normal role in this pathway, and the phenotypic consequences range from patchy to complete hair loss. The discovery that Hairless mediates thyroid hormone receptor-dependent gene repression provides the first molecular insight into the role of Hairless in congenital hair loss disorders. This disco...Post-transcriptional regulation of COX2 in tumor cells
... of blood vessels that permit tumor growth and the phenotypic changes that result in metastasis. Much of the analysis of COX-2 regulation has focused on transcriptional control, but Dixon and coworkers now show that post-transcriptional effects may be equally important. The COX-2 mRNA, like other gene products ...Phenotypic variability in cystic fibrosis
...ymptoms in the intestine or elsewhere. Some of the phenotypic variability results from the presence of different disease alleles, but, as Bronsveld and colleagues note, a great deal of variability persists even among people carrying a single allele in homozygous form. The authors worked with sets of affected tw...New findings represent the first aerobic capacity QTLs identified in genetic models
...at suggest that between 70-90 percent of the total phenotypic (characteristics devolved from the interaction of ... exhausted by 300 meters. This wide difference in phenotypic values suggested that the COP and DA rats could serve as parental strains for a genetic cross to tes......help alleviate baldness in K17 knockout mice. The phenotypic variability exhibited by K17-deficient mice may help explain the clinical heterogeneity inherent to a subset of human keratin-based skin disorders. Inherited mutations in the human keratin 17 gene cause two separate epithelial disorders related to ec...Transmission of drug-resistant HIV on the rise
..." Grant said. Resistance can also be determined by phenotypic testing to assess the susceptibility of the virus ...eptible, but not impervious, to its effects. Using phenotypic testing, the researchers found a dramatic decrease in the transmission of virus resistant to a third...Computational geneticists revisit a mystery in evolution
...nnect between great genotypic variation and little phenotypic variation was through natural selection.'' In 1942...ion to explain the disparity between genotypic and phenotypic variation has several problems. First, a prerequisite for canalization is genetic variation - but if...ASPB Annual Meeting, August 3-7, media tip sheet
...sed to soil radiation for hundreds of years and on phenotypic abnormalities and protein repair. ASPB Leadership in Science Public Service Award will be presented to Dr. Norman Borlaug, Nobel Peace Prize Laureate and father of the Green Revolution, at 6 p.m. Saturday, August 3, Plaza Ballroom D, Adam?s Mark Hot...Cell transplantation could restore cardiac function after heart attack
...tion of non-degenerated functional myotubes, and a phenotypic switch towards slow-twitch fibres that might allow them to sustain a cardiac workload over time."...48-wk resistance data comparing GW433908 boosted & unboosted with nelfinavir
...e of resistance was determined using genotypic and phenotypic analyses of viral protease, reverse transcriptase and gag cleavage sites at baseline and during therapy for patients who were experiencing virologic failure or who had ongoing viral replication. The potential development of virological resistance is ...