Richard A. Lerner and Peter G. Schultz to receive Paul Ehrlich and Ludwig Darmstaedter Prize 2003
... generated antibodies against molecules containing phosphate and phosphonate groups. They resemble the activated transition states in their three-dimensional structure, such as in ester hydrolysis. The new antibodies were specifically directed against the transition state, stabilized it and thus accelerated re...Johns Hopkins scientists create forgetful mouse
...f the protein that could not be modified by adding phosphate groups. In their experiments, preventing phosphorylation of the receptor kept it from responding normally to external stimulation in the lab and limited how long animals could store new memories. "Since 1986, phosphorylation has been recognized as a...Toxicogenomics provides insight on assigning breast cancer drugs
... cellular circuitry. Phosphorylation occurs when a phosphate group is removed from ATP, a component in many cellular circuits. While it is possible to know of the existence of a gene product in a cell, Petricoin takes it a step further to find out what it is doing--he is concerned not just with the receptor of...Phase III, 48-Wk NEAT study results comparing GW433908 to Nelfinavir presented today
...ent). The investigational PI, 908, is the calcium phosphate ester pro-drug of amprenavir. Patients in the 908 group took 2 pills BID compared to 5 pills BID in the nelfinavir group. 908 is being studied in several dosing presentations, all without food restrictions: twice a day (BID) and once a day (QD) in c...24-Wk data from CONTEXT trial comparing GW433908/ritonavir QD & BID to Lopinavir/ritonavir BID
...out food or fluid restrictions. 908 is the calcium phosphate ester pro-drug of amprenavir (APV) and was co-discovered by GlaxoSmithKline (GSK) and Vertex Pharmaceuticals (Nasdaq: VRTX). The primary objective of CONTEXT is to assess antiretroviral response by measuring the time averaged change in viral load (vR...48-wk resistance data comparing GW433908 boosted & unboosted with nelfinavir
...nscriptase inhibitors (NRTIs). 908 is the calcium phosphate ester pro-drug of amprenavir (APV) and was co-discovered by GlaxoSmithKline (GSK) and Vertex Pharmaceuticals (Nasdaq: VRTX).In the SOLO study, no patients (0 percent) in the 908/r arm, out of 32 subjects experiencing virologic failure or with ongoing...January GEOLOGY and GSA TODAY media highlights
...e Middle and Late Ordovician chert, carbonate, and phosphate were deposited along the southern margin of North America. These sediments, along with similar sediments around the periphery or North America and other mid-latitude continents indicate abundant oceanic upwelling during this period. We interpret th...IFDC innovative technology increases farmers' agricultural productivity, maintains resource base
...ve the pH level; soluble sources of phosphorus and phosphate rock are frequently used to increase the availabil...e fields. The ISFM package that she uses includes phosphate rock, legumes (cowpeas or groundnut) and other fertilizers. On her farm of less than 1 ha, she appl...Salk Institute and SUGEN scientists map 'human kinome'
... regulators of cell behavior. By chemically adding phosphate groups to other proteins, they control the activity of up to 30 percent of all cellular proteins, and are involved in almost all cellular functions. They are especially important in sending signals between and within cells, and in orchestrating compl...Fosrenol (TM) reduces damaging high levels of phosphate in end-stage kidney disease patients
...trade; (lanthanum carbonate) reduces damaging high phosphate levels, which most end-stage renal disease (ESRD) ...onate has the potential to reduce dangerously high phosphate levels safely and effectively. Previous data from a separate phase 3 long-term safety study indicat...Tailor-made cancer drugs: Wave of the future?
...l. All DNA is formed of three basic components: a phosphate and a sugar, which combine to form the sides of the double helix "ladder," and a base that forms the ladder's "rungs." All variances in DNA, including cancerous mutations, are the result of unique sequencing of the four types of bases, denoted A, G, ...Tiny plant may yield big environment, energy payoffs
...that Chlamydomonas shares many of the responses to phosphate stress with crop plants. Working with Chlamydomonas, we can quickly test ways to improve tolerance or adaptation, perhaps leading to ways of engineering crop plants for the same purpose," he says. If fertilizer use were decreased, phosphorous runoff...Natural insecticide identified as potential cancer prevention agent for early stage lung cancer
...ll survival signal for tumor progression by adding phosphate to the proteins involved in cell cycle regulation and pre-cell death factors. Results of this study found that the activation of Akt is a common feature in the early stages of cancer and that inhibition of Akt might be a potential target for chemopr...Researchers create new strategy for removing arsenic from soil
...Plants actively take up arsenate, mistaking it for phosphate and transfer it to their leaves. The team engineered the arsC gene to be turned on strongly by light, which falls naturally on leaves and stems. (Light-induced gene expression as a tool for genetics, also pioneered by the Meagher lab, has been around...New technique widens the lens on cancer, could lead to new therapies
...sine and an adjacent guanine, linked together by a phosphate molecule. In cancers, it is these regions, known as CpG islands, that some times are aberrantly methylated in tumor suppressor genes. Scientists have long been able to detect aberrant DNA methylation within a cell's genome using an enzyme known as No......arch. Along with the fresh water, more nitrate and phosphate are entering the Waddenzee. During the past 140 ye... of nitrate and to a lesser extent the quantity of phosphate have increased. The Netherlands Institute for Sea Research has also observed a shift in the species ...MIT team probes arsenic and old lakes
...o has implications for other pollutants, including phosphate and toxic metals (e.g. lead, cadmium and zinc). These contaminants are similarly adsorbed onto iron oxides, so they are expected to have similar behaviors in lakes. Hemond further expects that nitrate pollution could be important in groundwater or ma...Research reveals how cells protect against stress
... a type of protein called a kinase, which attaches phosphate groups to other proteins. The resulting cascade of events ultimately causes closure of microscopic pores on the plants' leaves in an effort to limit the loss of moisture. In the present research, Assmann's group found that one of the targets of this...New method of DNA testing promises to transform medical diagnostics
...is a synthetic analogue of DNA, which replaces the phosphate sugar backbone of DNA with a peptide backbone. "Peptides" are the molecules out of which proteins are made. PNA, which is soluble in water, is neutral--neither positively nor negatively charged. One strand of PNA comes together ("hybridizes") with......ed a protein kinase--to catalyze reactions between phosphate groups and other proteins inside the cell," Ma says. "Based on our research and the well-known function of similar proteins in animal cells, we speculate that the EMS1 protein that results from the EMS1 gene we discovered behaves like a protein kin...