New effort to increase coal production announced
...lysis, and a hydrosizer for the recovery of coarse phosphate and coal. Most recently, Yoon and the members of his research center developed novel technologies, now close to commercialization, that separate water from the surface fine particles that are close to commercialization. Yoon has served as the directo...Study reveals molecular key to tumor suppressor activity
...ng that p53 accumulates in the nucleus by adding a phosphate to the protein. Previous research has shown that ...by DNA damage. "We found that the addition of the phosphate inhibits the export of p53 to the cytoplasm. We found a small sequence or small peptide in p53 that'...Putting randomness to work: unique form of nanoscale random motion may drive key cellular functions
...ll bound after ATP hydrolysis and release of a phosphate -- releases from the microtubule. ATP hyd...operation that involves acceptance or removal of a phosphate controls a protein's affinity for binding to other proteins it encounters as Brownian motion...Florida scientists find enzyme replacement restores muscle strength in mice with Pompe's disease
...to human GAA and modified by adding high levels of phosphate and altering some of its sugar molecules. The alterations enable the protein to successfully reach the location in the cells where glycogen builds up. This type of enzyme formulation has higher potency than previously tested materials. The mice rece...Scientists find great-granddaddy of enzyme family
...he machinery of cells by releasing energy when its phosphate chemical bond is broken. A study of the structure ...sferases, named for their ability to make or break phosphate bonds in cells. This process, called phosphorylation, is used to initiate a number of activities, in...Novel protein is both ion channel and enzyme
...vates other proteins by phosphorylatingor adding a phosphate to them. "The most exciting part of this finding for us was that TRP-PLIK is bi-functional," he said. "It contains a domain whose opening and closing acts as a gate for calcium and a domain that acts as a kinase. "The finding is also important becau...Scientists track phosphate to better understand global warming
...e we can make another jump in our understanding of phosphate cycling because of the availability of new technol...rus compounds in water and soil, estimate how fast phosphate cycles through natural reservoirs, estimate long-term phosphorus burial in the oceans through geolog...Colorado set to fly biomedical experiments on September shuttle flight
... by kidney cells, which helps maintain calcium and phosphate levels in human blood. A sophisticated container known as an Isothermal Containment Module developed by BioServe will automatically heat the kidney cell samples to the normal human body temperature of 98.6 degrees F. Samples will be drawn from th...UCSF researchers identify regulator of critical brain messenger, hinting at therapy
...role. Previously known as brain-specific inorganic phosphate transporter, the researchers have renamed the prot...ions on the plasma membrane to transport inorganic phosphate into a neuron....Molecular mechanism for learning and memory is identified
...tion is a fundamental molecular process in which a phosphate is transferred to a protein, causing the protein to change shape and function. In the case of GAP-43, the protein kinase C (PKC) is the enzyme responsible for its phosphorylation. The researchers first studied four different types of mice and their...Fact sheet: the Report on Carcinogens - 9th edition
... manufacture of isopropyl alcohol, lead batteries, phosphate fertilizers, soap and detergents, synthetic ethanol, and pickling and other acid treatments of metals. Dyes metabolized to benzidine - Dyes metabolized to benzidine are listed in the 9th Report as "known human carcinogens." These dyes are used ma...Calcium is not as readily absorbed from soy milk as from cow's milk
...t a standard fortification of 500 mg of tricalcium phosphate per serving would result in the same amount of calcium absorbed from a serving of soy milk as would be absorbed from a serving of cow's milk containing 300 mg calcium. Heaney R P et al. Bioavailability of the calcium in fortified soy imitation milk,...Study may help clarify how cells grow
... in Detroit, focused on an enzyme called carbamoyl phosphate synthetase, or CPS II. Deep within the cell's mole.... What we find is that the properties of carbamoyl phosphate synthetase from tumor cells are consistent with increased phosphorolation by MAP kinase," Graves sai......ern and her colleagues works by snatching a single phosphate ion from the amino acid histidine. The phosphoryla... histidine molecule on one component to transfer a phosphate ion to an aspartate molecule on a second component. A strikingly similar two-component mechanism ope...Cooperative action of two proteins causes damaged cells to "self-destruct"
...pendent. Irradiation activates c-Abl (through both phosphate binding and othermechanisms), and c-Abl subsequently activates p73 by phoshorylating it. "Our research suggests thatboth p73 and c-Abl influence whether a cell becomes cancerous following DNA damage," Shaul explains."If the function of either of thes...Peering at a machine that pries DNA apart
... does. Scientists knew that the helicase splits a phosphate off dTTP--a relative of thefuel molecule ATP--to free up chemical energy. It must somehow convert this intothe physical force needed to separate the Watson-Crick bonds joining thedouble-strand DNA base pairs. It also must harness energy for large cha...Cancer gene is normally a 'carpenter' in the cell
...ne kinases,that trigger other proteins by adding a phosphate to the amino acid tyrosinethat is part of the prot...t's more, theirstudies revealed that the Src added phosphate to the c-Abl protein, the normalaction of a kinase triggering another enzyme. The scientists a...Scientists identify novel component of cell-fate pathway
...t is a member of a family of enzymesthat transfers phosphate groups from a donor to an acceptor protein, oftenleading to an increase in the latter's activity. Although CKI's function waspreviously known, its biological role was not. The scientists found that CKIhelps to transmit Wnt signals after the signals e...Scientists uncover how a colon-cancer prevention drug works
...at sulindac inhibits a kinase (an enzyme that adds phosphate ontoits target), which in turn prevents the activation of NF-kB," Gaynor said. "Thiskinase should be an excellent target not only for the development of novelanti-inflammatory agents but also for the development of agents to inhibit thegrowth of canc......that degradation of TIMdepended on the addition of phosphate to the protein by enzymes called tyrosinekinases. Such basic understanding of the biological clock machinery could haveclinical implications, said Sehgal, since researchers have found the clockcomponents to be basically the same in flies and humans....