Stretching DNA on a tiny scale, researchers probe the basis for its compaction
...complex of proteins widely conserved in evolution, physically compacts DNA in a manner dependent on energy from ATP. The finding is significant because the Condensin complex, which is essential for life, has been known to play a key role in the dramatic condensation of genomic DNA that precedes mitosis and cell...ORNL's nanobiosensor technology gives new access to living cells molecular processes
...ve cell. The "nanobiosensor" allows scientists to physically probe inside a living cell without destroying it. As scientists adopt a systems approach to studying biomolecular processes, the nanobiosensor provides a valuable tool for intracellular studies that have applications ranging from medicine to national...Scripps scientists look deep inside sharks and their high-performance swimming system
...ea of the body that is moving back and forth--it's physically separated," said Donley. "It's exactly like tuna in that respect." The authors say these characteristics distinguish lamnid sharks and tunas from virtually all other fish and arose independently in each, most likely the result of evolutionary selecti...Dramatic decline of California native frog linked to introduced trout in mountain lakes
...t doing this broadly in the high Sierra is neither physically nor politically feasible. Many lakes are too large and deep to allow removal of fish without the use of poisons, and fishermen would protest any loss of trout lakes, no matter what the impact on native amphibian populations. "This is a stopgap. At th...Molecular image of genotoxin reveals how bacteria damage human DNA
... target. By screening compounds by computer before physically testing them, drug makers save time and money. Stebbins' laboratory includes a drug-design team, which is currently designing molecules to thwart bioterrorism agents such as anthrax and plague. In the future, the lab might design a drug against the C...... epigenetic change in which a methyl group becomes physically attached to the region of a gene that regulates its production of protein, shutting it down. But Jones, who is one of the world's pre-eminent epigenetics experts, says that azacitidine's approval is bigger than its role in MDS. "This is the first app...Junk DNA yields new kind of gene
...rs have evidence that the new gene, SRG1, works by physically blocking transcription of the adjacent gene, SER3....s-somehow spills over to the nearby SER3 promotor, physically preventing it from being approached by an activator. "It is also possible that active transcription ...Obesity and hypertension: Two epidemics or one?
...n is highest in obese sedentary and lowest in lean physically active individuals. Physically active individuals ...iated with weight gain also appears to be lower in physically active individuals. As such, regular physical activity is recommended for individuals with elevated ...Memory fails you after severe stress
... intense interrogation. Half of the subjects were physically threatened, and this caused them to show all the signs of intense physiological stress- very high heart rate and levels of adrenalin and cortisol, combined with plummeting sex hormones. Twenty-four hours after release from the camp, the subjects wer...NIH awards grant for cancer research to the University of Wisconsin
...ery requires approaches that bring together---both physically and intellectually---scientists and clinicians with a broad range of expertise and skills," said Elias A. Zerhouni, M.D., director of NIH. "By removing physical barriers, researchers at this facility can work as interdisciplinary teams---taking resea...Severe depression associated with greater number of nerve cells in thalamus region of brain
...so discovered that this portion of the thalamus is physically larger than normal in people with MDD. Located in ... brain that is involved in emotional regulation is physically different." Four groups were represented in the study: subjects with major depression, with bipolar ...Technology could enhance accuracy of breast biopsy
...ize, making an emotionally draining procedure less physically traumatic....ORNL nanoprobe creates world of new possibilities
...on or treatment of the sample. This may consist of physically removing the sample and diluting it in a liquid containing silver nanoparticles; however, this practice is unnecessary with the ORNL nanoprobe. Vo-Dinh and Life Sciences Division colleagues David Stokes and Zhenhuan Chi experimented with nanoprobes m...Most Americans not sure about the sources of high cholesterol
... a heart healthy diet, managing weight and staying physically active are essential lifestyle components we've encouraged for years. We've also emphasized the importance of informed patients talking with their doctor to ensure cholesterol goals are met. These findings reinforce that importance. Patients should...Molecular motor shuttles key protein in response to light
...ht not only by mechanically shrinking the pupil to physically limit how much light enters the eye, but also by a chemical response. Building on their previous work showing that specific proteins in eye cells are redistributed in response to bright light, the Johns Hopkins team now reports how a key protein call...Regular physical activity really does boost immune system in older men
...pularly accepted notion that people who maintain a physically active lifestyle will enjoy the benefits a stronge...g (20-35 years of age) and older (60-79) men, some physically active and some sedentary. Using KLH overcame a major problem in many earlier age vs. exercise stud...Women who have donated eggs sought for national study
...generally ignored. No one knows what has happened physically and emotionally to these women. It is important to understand their experience so that adjustments can be made to the assisted reproduction technology system if they are necessary," she said. The researchers also are interested in learning how wome...University of Pittsburgh receives $10 million grant for head and neck cancer
...tionally. "Head and neck cancer is one of the most physically and emotionally debilitating cancers," said Jennifer Grandis, M.D., principal investigator of the grant and professor of otolaryngology and pharmacology, University of Pittsburgh School of Medicine, and director of UPCI's Head and Neck Cancer Program...Disease diagnosis, drug development focus of UH prof's biochip research
... http://nanotech.colayer.net/ for those unable to physically attend the conference in Australia. This virtual version of the conference also will provide Internet participants an opportunity to post questions and discussion items. Nanoscience is strongly multidisciplinary, and the conference will reflect t...Common cold virus can cause polio in mice when injected into muscles
...uscle movement. The site in the muscle where axons physically attach is called a neuromuscular junction. These junctions likely served as the cold virus' portal of entry into the nervous system. "We gave the coxsackievirus a distinct advantage by injecting it directly into muscle, where it had direct access to ...