Researchers determine genetic cause of Timothy syndrome
...October 1, 2004, issue of the journal Cell, that a pinpoint mutation in the CaV1.2 calcium channel was the sole cause of Timothy syndrome. Keating collaborated on the studies with researchers from Children's Hospital, Boston, Harvard Medical School, the University of Utah, the University of Pavia in Italy and...Chemical derived from vitamin-E shows early promise as cancer drug
...entify smaller cancer lesions. The equipment could pinpoint the injected cancer cells in the animals because the cells had previously been genetically modified by co-author LuZhe Sun from the University of Texas Health Science Center in San Antonio to fluoresce bright green under proper exposure. Using......ced defective enamel. Other experiments set out to pinpoint the part of the protein responsible, pointing researchers toward the proteins so-called carboxyl terminusa region made up of many negatively charged amino acids. People concentrated on this region, according to Shaw, because it has several negatively...Brown ecologist garners major National Science Foundation grant
...nt times. They'll also screen the plant's genes to pinpoint which ones affect flowering responses to different environmental signals, and they will study natural variants of these genes that cause these reproductive differences. The team will then create new plant lines that differ only by a single gene, allo...Brain has center for detecting sound motion
... of sounds, even while you retained the ability to pinpoint their location. That's exactly the experience of a patient reported by Christine Ducommun and her colleagues, who used studies of the patient to demonstrate conclusively for the first time that the brain has a specialized region for processing sound ...JCI table of contents September 15, 2004
...hat takes a "Venn Diagram" approach to efficiently pinpoint mutations in this system. They utilize this metho... techniques provide a rapid and effective means to pinpoint mutations in diseases that have complex genetic backgrounds. An accompanying commentary by Eric Scho...Venn diagram tactics to vet complex disease
...hat takes a "Venn Diagram" approach to efficiently pinpoint mutations in this system. They utilize this metho... techniques provide a rapid and effective means to pinpoint mutations in diseases that have complex genetic backgrounds....... number of growth-related genes. They were able to pinpoint BMP4 as a candidate for mediating growth, Chuong says. In humans, several BMPs play a role in enhancing the rates of cell division and growth and regulating major developmental events including bone differentiation. Deregulation of BMP pathway activi...Analysis of gene expression in lymphoid cells can determine lymphoma cancer
...lymphoid cells in a sample of blood can accurately pinpoint lymphoma, according to researchers at Temple Unive...f CDK9 and CYCLIN T1, they were able to accurately pinpoint the type of lymphoma--Hodgkins or non-Hodgkins--as well as its stage of advancement. Non-Hodgkins l...One-hundred-fifty year old lessons of John Snow still relevant today
... Street pump was the culprit. While he was able to pinpoint the Broad Street pump as the source of the epidemic, he did it by much simpler means. He interviewed survivors and relatives of those who had died from cholera. Those who were sick or died got their water from that particular pump. "The map was used ...New genetic research demonstrates possible cause of inherited form of Parkinson's disease
...-synuclein gene. This is the first study that may pinpoint the mechanism by which the mutant gene initiates a cascade of events that causes this devastating neurological disease. "This discovery could aid in the development of new, targeted treatments to slow or stop the disease progression," said David Sul...When is a mouse like a test tube?
... medical tracers to such cells to allow doctors to pinpoint them in the body. "The fact that this works is remarkable," wrote David A. Tirrell of the California Institute of Technology in an accompanying News & Views article in Nature. "The labeling strategy described by Bertozzi and colleagues allows one to ...Schizophrenia gene variant linked to risk traits
...gnition, increasing the risk for schizophrenia. To pinpoint the section of the gene responsible for these changes, scientists are exploring a region where the gene may differ by one letter at a location called SNP4. The normal variation is spelled with either an 'A'--the more common of the two--or a 'G'. Pati....... Once those tunnels are disabled, researchers can pinpoint the information that connexins pass between nerve cells and determine how that information affects how the body's development and function. A technique already exists to study connexins. Scientists can remove, or "knock out," genes that hold the rec...U-M scientists find common virus in human prostate tissue
...state cancer cells, but this study is the first to pinpoint the location of viral protein expression to one precursor stage in the development of prostate cancer, and to a specific location within prostate cells," Imperiale says. Results from the U-M study, published July 19 in the advance online edition of ...Fundamental change to Immunology 101
... enter the thymus. Finally being able to pinpoint what cell type connects the bone marrow to the thymus in T-cell production may help researchers understand what happens when this part of hematopoiesis goes awry. "If you want to understand where T cells come from and what goes wrong when you stop ma...Mutant mice lead to memory insights
...lleagues created a sophisticated knockout mouse to pinpoint whether CBP's role in histone acetylation is central to its function in forming long-term memories. Their mutant mouse was constructed such that the researchers could switch on a "dominant-negative" form of the CBP gene -- which would eliminate norma...Stem cells commit to a future of fat with one signal
...ences of committed and non-committed stem cells to pinpoint other key proteins (and genes). These mouse "master-controller" proteins will likely have human counterparts, since both species have very similar proteins and developmental pathways. "There are likely to be many genes involved in commitment to ...Lupus Research Institute awards $3 million in novel research grants to further new science in lupus
...apoptotic nucleosomes play in the cause of SLE and pinpoint the source of this dangerous material. This work may provide a stronger rationale for targeting new therapies at apoptotic nucleosome. Robert M. Clancy, PhD, New York University School of Medicine, Hospital for Joint Diseases, New York CIRCULA......e neural mechanisms underlying implicit memory, to pinpoint how they are compromised in both the healthy elderly and those with Alzheimer's disease." ...