Tag: "pinpointed" at biology news

Landmark gene agreement announced by Samoan government and UC Berkeley for anti-AIDS drug Prostratin

... build the molecule Prostratin. Once Keasling has pinpointed the key enzymes and cloned their genes, he plans to insert the genes into a strain of E. coli bacteria that he has created to produce isoprenoid compounds like Prostratin. The product of more than 10 years of genetic engineering, the bacterial factor...

Landmark agreement between Samoa and UC Berkeley could help search for AIDS cure

... build the molecule Prostratin. Once Keasling has pinpointed the key enzymes and cloned their genes, he plans to insert the genes into a strain of E. coli bacteria that he has created to produce isoprenoid compounds like Prostratin. The product of more than 10 years of genetic engineering, the bacterial factor...

Researchers determine genetic cause of Timothy syndrome

Howard Hughes Medical Institute researchers have pinpointed the genetic cause of a devastating but rare childhood disorder, called Timothy syndrome, which underlies a form of severe cardiac arrhythmia. The research shows that children who have the syndrome develop spontaneous genetic mutations that interfere...

Breaking new ground in germ cell guidance

...optosis mediator, caspase-3. Hanyu-Nakamura et al. pinpointed the site of the mutation to the locus for the guidance gene, wunen2 . The products of this gene and its relative, wunen , have been known for some time to play important roles in the guidance of Drosophila pole cell migration by somatic cells. The ge...

Rare deficit maps thinking circuitry

...'s National Institute of Mental Health (NIMH) have pinpointed the site of a defect in a brain circuit associated with a specific thinking deficit. Their study demonstrates how a rare genetic disorder, Williams Syndrome, can offer clues as to how genetic flaws may translate into cognitive symptoms in more common...

How an insidious mutation fools DNA replication

DURHAM, N.C. -- Biochemists have pinpointed how a flaw in DNA that is central to mutations in cancer and aging fools the cellular enzyme that copies DNA. Their finding explains how oxidative DNA damage -- a process long believed to underlie cancers and aging -- can create permanent genetic dam...

Clusters of alterations on PIK3CA gene found in brain cancers

...cally to thwart tumor growth. Yan and colleagues pinpointed a cluster of 13 mutations on two particular areas of the PIK3CA gene, exons 9 and 20. The mutations were identified in 14 percent of anaplastic oligodendrogliomas, 5 percent of medulloblastomas, 5 percent of glioblastomas and 3 percent of anaplastic ...

Pump failure implicated in a form of dystonia

...atricia de Carvalho Aguiar and her colleagues have pinpointed for the first time genetic mutations that underlie...ked to inheritance of the disease. The researchers pinpointed mutations in one particular gene, called ATP1A3, as common in all the families. This gene is the blu...

Yale researchers receive $4.5 million grant to study spinal cord repair

...Center. In recent months, animal studies at CERF pinpointed a molecule responsible for chronic pain in SCI and blocked the pain successfully by targeting the molecule. "All of our projects, aimed at restoration and preservation of neurological function, have a sequential overall structure - studies at the mol...

UCLA scientists decipher how the brain retrieves and stores our oldest memories

For the first time, UCLA neurobiologists have pinpointed a region of the brain called the anterior cingulate as responsible for retrieving and storing distant memories. Published in the May 7 edition of Science, the findings may suggest new ways of treating memory disorders, including Alzheimer's disease ...

Closing in on the cellular culprits of schizophrenia

...ing to do with schizophrenia? The genetics studies pinpointed a link between dysbindin and schizophrenia. This clue prompted us to investigate dysbindin in the brain where we found that it is highly expressed and highly abnormal in schizophrenia."...

Researchers confirm genetic link between hereditary breast and prostate cancer

...cimens taken from 1,472 healthy men. Investigators pinpointed BRCA2 not BRCA1 as the common genetic link to prostate cancer. The results show that the frequency of certain BRCA1 and BRCA2 mutations was 5.2 percent in the prostate cancer cases compared to 1.9 percent in the healthy vo...

Technique plucks rapidly evolving genes from a pathogen's genome

...y as well as those that change slowly already has pinpointed new targets for researchers developing drugs again...of finding rapidly evolving genes, and has already pinpointed previously unknown genes in the tuberculosis and malaria parasites that could be potential drug tar...

SAGE-acious prediction of thyroid carcinoma

...r analysis with these genes by quantitative RT-PCR pinpointed four genes (DDIT3, ARG2, ITM1, and C1orf24) with statistically significant gene expression differences between FTC and FTA. They used these differentially expressed genes as predictive markers for carcinoma in a series of patient cases. RT-PCR analys...

Biochemical clues to long lifespan revealed

...cience. Previous studies in yeast and worms pinpointed a gene known as Sir2 as a key regulator of lifespan: deleting Sir2 limits lifespan, and extra copies lengthen it. Sir2 has a counterpart in mammals, but until now, very little was known about how it worked or what it had to do with aging. Working ...

Monkey talk, human speech share left-brain processing

Scans have pinpointed circuits in the monkey brain that could be precursors of those in humans for speech and language. As in humans, an area specialized for processing species-specific vocalizations is on the left side of the brain, report Drs. Amy Poremba, Mortimer Mish...

Nomadic outposts of transplanted stem cells tracked in Stanford study

...ike a campfire at a new settlement, this dim light pinpointed the cells' location. Although the light from luciferase isn't bright enough to see by eye, an ultrasensitive video camera originally developed by Contag can detect the faint light and show researchers where the glowing cells have settled. The experim...

Newly identified gene may halt fuzzy, moldy fruit

...re highly susceptible to Botrytis, the researchers pinpointed the resistance gene, BOS1. Once Mengiste and his team found the gene, they were able to show that it does more than restrict the growth of the pathogen. BOS1also protects the plant from stresses, such as drought and soil salinity. These stresses are ...

New study identifies gene signaling puberty

... some careful detective work, the U.S. researchers pinpointed the gene that causes IHH in this family," said Louis De Paolo, Ph.D., project officer in NICHD's Reproductive Sciences Branch. "Using the mouse model, the British researchers gained an important insight into the function of the gene."...

Building a better atlas of yeast proteins

...titute researchers have measured the abundance and pinpointed the cellular locations of more than 4,000 proteins in yeast. Proteins are the workhorse molecules of the cell. They catalyze reactions, transport molecules within the cell and switch genes on and off. Measuring the abundance of and identifying the ce...

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