JCI table of contents: October 1, 2002
...of lactotrophs -- prolactin-producing cells in the pituitary -- is controlled through a negative feedback loop ...th mutant strains developed large prolactinomas -- pituitary adenomas that produce prolactin. Males had smaller tumors overall, but a significant difference betw...New depression studies reveal persistent serotonin system abnormality in patients
...olactin and several other hormones released by the pituitary gland at the base of the brain in response to the serotonin challenge test. Their goal was to learn whether the abnormality was always present or detectable only when patients were depressed and disappeared like fevers do when infections end. They t...Scientists develop new drug to combat tamoxifen-resistant tumours
...and also in the liver, lungs, ovaries, adrenal and pituitary glands and in the bone marrow, but extremely low amounts in the brain. This means that neither TAS-108 nor its metabolite would damage the brain of patients. Mr Yamaya said: TAS-108 accumulates well in tumour tissues and these preclinical results su...Long-distance command sends human growth hormone into action
...apy for the type of dwarfism that results when the pituitary gland is unable to manufacture the hormone, scient...wth: Without it, humans develop a condition called pituitary dwarfism, in which their physical stature never reaches five feet. Liebhaber, Cooke and their collea...Growth hormone may boost production of disease-fighting cells in elderly
...mplanted either synthetic growth hormone-secreting pituitary epithelial cells or injected recombinant growth hormone into their experimental rats. Both approaches yielded positive changes. Previous research, based on a simplistic approach of preparing single-cell suspensions from whole tissue and counting the...... indicate the presence of pathology, for instance, pituitary tumor. Benefits for postmenopausal women include a lowered risk of heart attack (estrogen lowers LDL and raises HDL levels), and prevention of osteoporosis, since the rate of bone loss is directly linked to a drop in estrogen levels. Background Despi......teroids from the testes ensure that the brain, the pituitary gland and testes develop properly. Because the cor...ly of steroids, communication to the brain and the pituitary (a gland under the brain) is reduced. This means that, like the testes, these organs develop more sl...More help for infertile women with polycystic ovary syndrome
...lin may interrupt normal communication between the pituitary gland and the ovary. "Normally, the ovary and pituitary glands talk to each other," explains Ratts. "We think that insulin interferes with the signals, like......n-releasing hormone receptor-2), which is found in pituitary gland tissue and in other areas of the brain, actu...opin-releasing hormone (Crh), which stimulates the pituitary gland to release additional hormones. These hormones from the pituitary gland cause the adrenal glan...Researchers identify molecule crucial to adjusting bodys internal clock
...ademy of Sciences, the scientists point afinger at pituitary adenylyl cyclase-activating peptide (PACAP), whose function had been a mystery. In both animal and cellular studies, they found that PACAP works in concert with glutamate, anothermolecule in the nerve fibers between the retina and hypothalamus, home ...Stressed-out mice offer clues to depression, anxiety, anorexia
...nts these hormones from activatingreceptors in the pituitary and brain." In future research, Seasholtz and her colleagues plan to continue working withthe U-M mouse model to understand how all the stress hormones and receptorsinvolved in the CRH system work together to produce anxiety-like behavior. Themice...Learning how organs tell left from right
...ockout mice had defective growthin their teeth and pituitary glands, the source of growth hormone. "Cellproliferation stops. There is a failure to progress past the initialdetermination of organ identity," Rosenfeld said. Summarizing the results of these studies, which are published in theSeptember 16, 1999, ...Growth hormone involved in diabetic kidney disease, study finds
...ine Society in San Diego. Produced by the pituitary gland, growth hormone promotes normal bodygrowth and development by altering chemical activity in cells. It stimulates theproduction of protein in muscle cells and the release of energy from thebreakdown of fats. Kopchick led the team of rese......d acts appropriately to regulatethe release of the pituitary corticotropin (ACTH) hormone, which controlsadrena...hin the pituitary, allowingvery fine tuning of the pituitary response to brain and peripheral signals." This important discovery, which will be published in the ...Fly Tumor Points Way To New Understanding Of Cancer Development
... developed ovariantumors, soft-tissue sarcomas and pituitary disorders. "This finding is important because it is the first example showing that aninvertebrate tumor suppressor is also a tumor suppressor in mammals," said Xu."This also suggests that some human cancers may be caused by a mutation of the LATS1 ......releasing hormonereceptor (GHRH-R), which triggers pituitary growth hormone secretion and growthin humans. The mutated GHRH-R causes growth hormone deficiency due to GHRHresistance. Molecular genetic testing showed that inheritance of the dwarfism traitis transmitted in an autosomal recessive manner; i...Medical Tip Sheet - November 1, 1998
... Medical Center gives surgeons a panoramic view of pituitary tumorsites and results in reduced operating time, fewer complications, lessdiscomfort for the patient and a dramatically shorter length-of-stay. A42-year-old woman from Indiana had surgery 11/04, and is anticipated to bereleased 11/06, flying home to...Research Suggests New Way To Gauge A Woman's Fertility
... “The decline in ovarian inhibins but not in pituitary FSH suggests that the inhibins may be a better and more direct marker of ovarian age than FSH,” Danforth said. Co-authors for this research included Laura Arbogast, Jamil Mroueh, Moon Kim, Elizabeth Kennard, David Seifer and Chad F...Fully Endoscopic Brain Surgery At Cedars-Sinai Medical Center
... highly successful brain surgery for patients with pituitary tumors andother skull base disorders. According t...t about 2 hours compared to 4 hours fortraditional pituitary surgery. Dr. Shahinian expects that time to shorten evenmore) Dramatically reduced length of stay i...Researchers Identify And Isolate First Gene For A Form Of Insulin-Dependent Diabetes
...The syndrome also caninclude diabetes insipidus, a pituitary gland disorder associated with intensethirst and the need to excrete large amounts of urine. Some people with WolframSyndrome also lose their hearing. The disorder is caused by mutations in a single gene called WFS1, theresearchers found. Id...