Charting the future in prostate cancer care: A call to action
... 1993, The Prostate Cancer Foundation has played a pivotal role in supporting and funding R&D breakthroughs to defeat this disease. The timing is becoming ever more critical. As the baby boomer men reach the target age for prostate cancer, beginning at age 50, this disease will become the cancer with the gr...Bacteria use 'molecular lasso' to cop copper
...iet of close to 43 billion tons a year. Playing a pivotal role in this drama is the methanobactin molecule, a tiny, pyramid-shaped compound with a cleft that holds a single atom of copper in place. The bacteria churn out methanobactin molecules in large numbers and send them into the environment to fetch co...Optimizing protein's 'death domain' halts leukemia in laboratory study
... that you could take any alpha helix involved in a pivotal protein interaction, relevant to cancer or other diseases, and target it to that protein to disrupt the disease process."...Molecular staples shape a cancer killer
...actions between proteins. "The alpha-helix plays a pivotal role in many biological interactions," said Walensky. "So if we could target protein-protein interactions at critical biological control points using the natural, evolutionarily derived sequence for that protein target -- with just this minor modific...Brain's reward circuitry revealed in procrastinating primates
...sessive-compulsive disorder, so our finding of the pivotal role played by this gene and circuit may be of clinical interest," suggested Richmond. "For example, people who are depressed often feel nothing is worth the work. People with OCD work incessantly; even when they get rewarded they feel they must rep...Method to visualize gene activity may provide insight into normal development & genome function
... perfecting the overall labeling process were also pivotal in the development of the technique. "Up until now visualizing gene transcripts has been more art than science," says Kosman. "There was a lot of trial and error involved. We have developed a reliable technique that is powerful enough to generate a m......wing body of evidence that suggests YY1 could be a pivotal transcription factor in cancer. "YY1 interacts with several transcription factors involved in cancer, for example, Myc and Notch, and now we know it also regulates p53," says Ericsson. "No-one has yet looked at mutations in YY1, but the fact that it ...Growing replacement teeth and dental tissues
...splanted to an ectopic site. The latter report is pivotal in that it demonstrates that uncommitted mesenchymal stem cells, in association with oral epithelium, can be instructed to mimic developmental events leading to growth of a tooth structure comprised of enamel, dentin, and pulp, with a morphology rese...North Shore-LIJ research collaboration with Correlogic Systems to advance ovarian cancer blood test
...or the North Shore-LIJ Health System, is playing a pivotal role. "Upon validation, this blood test can dramatically change the lives of women at high risk for ovarian cancer," said Dr. Lovecchio. "When caught very early, the survival rate can be as high as 90 percent. Unfortunately, most of these cancers are...Breast cancer patients failed by treatment with taxol and taxotere respond to abraxane
... routine premedications. The previously reported pivotal Phase III trial demonstrated superior response rate and time to tumor progression in metastatic breast cancer patients versus Taxol....Fox Chase Cancer Center's Alfred Knudson Jr. named 2004 Kyoto Prize winner
... new horizon in modern cancer genetics, and made a pivotal contribution to major subsequent research developments in understanding human cancer. "Today, we are rushing ahead with incredible scientific and technological achievements, while inquiry into our spiritual nature lags deplorably," said Dr. Kazuo Ina...Moderate alcohol consumption increases plasma levels of a protective hormone
...estrogens in general," Hendriks continued, "may be pivotal in the protection from coronary heart disease in premenopausal women. An association between moderate alcohol consumption and breast cancer has been proposed, which may be mediated through an increase in estradiol." "A lot of the earlier work in thi...Landmark, pivotal Phase IIb/III trial of biotoxin for cancer pain begins
Investigators involved in the pivotal clinical trial of Tectin TM enrolled and dosed the first of up to 150 patients that will participate in the study. It is one of the largest Canadian clinical trials to evaluate the efficacy and safety of a drug for treatment of medically refractory ...Second generation targeted antibodies - It's all in the binding
...ram in EGFR structure and biology, and in a recent pivotal discovery participated in defining the 3D-structures of the extracellular domains of the EGFR and a related protein, erbB2/HER-2, which is implicated in many breast cancers. The most recent papers describe in detail how EGFR undergoes alterations in ...White House lauds Physiological Society for mentoring underrepresented minorities in biomedicine
...l careers in science can point to the APS as being pivotal in supporting their careers." A former Porter Predoctoral Fellow herself, Dr. Gunter-Smith said, "One of the achievements of which I am most proud is that of my students who have completed their PhDs, two are physiologists and both are former Porter ...JGI decodes wood & toxic waste-degrading fungus genome
...t fungi such as Phanerochaete chrysosporium play a pivotal role in the carbon cycle--the circulation of carbon from the atmosphere into organisms and back again. They also have demonstrated the ability to remediate explosive contaminants, pesticides and toxic waste with similar chemical structures to lignin...JCI table of contents, 2 April 2004
...estored CD8+ T-cell activity. This work marks the pivotal role that these regulatory T-cells play in controlling hepatic CD8+ T cell action during HCV infection and that the concomitant appearance off these two cell types may be the main factor in the establishment of chronic infection. TITLE: Hepatic expa......hat carried it and suspect that it could have been pivotal for the origin of human language. Young birds of many species need to learn the sounds they communicate with in a manner akin to the way infants learn to speak, which is in contrast to mice and non-human primates who don't learn their vocalizations. ...Combination therapy drives cancer into remission
... study demonstrates that determining the status of pivotal growth-controlling proteins within a particular tumor can be a crucial step in selecting a treatment regimen that is most likely to succeed. The researchers, including the lead author of the study--Dr. Hans-Guido Wendel--showed that upon biopsy and e...Astrazeneca announces EU marketing approval for Faslodex(TM)
...e approval of 'Faslodex' is based on data from two pivotal phase III trials,1,2 which compared the efficacy and tolerability of 'Faslodex' to that of the aromatase inhibitor 'Arimidex' (anastrozole) in the treatment of hormone sensitive advanced breast cancer in postmenopausal women who had previously been t...