Tag: "plaques" at biology news

Alzheimer's disease is not accelerated aging

...l as new techniques that enable imaging of amyloid plaques in people living with Alzheimer's. Together, these point toward a disrupted network in the brains of patients with Alzheimer's disease, which includes the medial temporal lobe and other regions of the brain that undergo atrophy and reduced glucose me...

Study explores gene transfer to modify underlying course of Alzheimer's disease

...tes with dementia severity, the density of amyloid plaques (which are abnormal protein deposits in the brains of patients with Alzheimer's disease), and loss of synapses in the brains of Alzheimer's disease patients. Alzheimer's disease is a common disease in aging, currently affecting approximately 4.5 mi...

Amyloid fibers sprout one step at a time

...id fibers. These fibers are similar to the amyloid plaques that clog the brains of patients with Alzheimer's ...ers form and what role they play in making amyloid plaques was unknown. Weissman and his colleagues sought to understand the dynamics of how the amyloid puzzl...

Penn scientists identify novel pathway in aneurysms

...sisting of fatty deposits that progress into major plaques that eventually break off from the inner lining and lead to heart attacks. "The danger of aneurysms is that we don't normally carry out routine screening for their detection and by the time they are found most of the progressive damage may have alrea...

Early clinical treatment can halt progression of Alzheimer's disease, UCI researchers find

... of two distinct brain lesions — beta-amyloid plaques and neurofibrillary tangles. Both plaques and tangles accumulate in specific brain regions critical to learning and memory. It is believed t...

Altered protein involved in a novel link to Alzheimer's disease

...ical features of Alzheimer's disease: beta amyloid plaques (caused by increased Abeta peptides), neurofibrillary tangles caused by hyperphosphorylation of tau, and brain atrophy/loss of neurons. Only low levels of the protein P25 are found in healthy brains. However, in the brains of people with Alzheimer's,...

Are nanobacteria alive?

...cified aneurysms (bulging blood vessels), arterial plaques and heart valves. They pulped the tissue, then filtered it to remove anything bigger than 200 nanometres and added the filtrate to a sterile medium. After a few weeks, the optical density of the liquid doubled, suggesting particles were self-replicat...

ADAM: Good enzyme for Alzheimer disease

...order, is characterized by the presence of amyloid plaques in the brain. These plaques are comprised of aggregates of amyloid beta-peptides (AB peptides), which are believed to play a cen...

JCI table of contents, 17 May 2004

...order, is characterized by the presence of amyloid plaques in the brain. These plaques are comprised of aggregates of amyloid beta-peptides (AB peptides), which are believed to play a cen...

Archaeologists announce discoveries at the ancient Maya site of Waka' in northern Guatemala

...tatus was identified by the presence of greenstone plaques that form a war helmet and by the presence of a carved royal jewel, or "huunal," that may have once been a part of this headdress. "This helmet is consistent with a kind we associate with the title 'Kaloomte', or 'supreme warlord'," Freidel says. "A ...

Could vitamins raise levels of bad cholesterol? Animal study suggests they might

...ted biochemical changes that made cholesterol form plaques that can block blood flow through the arteries. Although some subsequent clinical studies seemed to back up these findings, others did not. The new study by Dr. Fisher and his colleagues provides a different perspective on antioxidants. Surp...

Artificial prions created

...e for Creutzfeldt-Jakob's disease or the misshapen plaques of proteins that contribute to Alzheimer's disease....

'Protein-only' prions confirmed in FSU yeast study

...ted with neurological disorders in humans. Amyloid plaques in human brain tissue, for example, are a well-kno...iseases. Scientists have long debated whether such plaques are merely a symptom of such diseases or a cause. King says his work proves that, at least in ye...

Optically recording millisecond brain nerve impulses

...'d like to know, for example, how much Alzheimer's plaques affect the signal transmission in axons." Multiphoton microscopy, including second-harmonic generation, produces high-resolution, three-dimensional pictures of tissue with minimal damage to living cells, using a laser that produces a stream of extrem...

Anti-interferon beta antibodies in MS care: A consensus

...scar tissue. These damaged areas are also known as plaques or lesions, and sometimes the nerve fiber itself is damaged or broken.When myelin or the nerve fiber is destroyed or damaged, the ability of the nerves to conduct electrical impulses to and from the brain is impaired or disrupted, and this produces t...

Purdue chemist 'mussels' in on secrets of natural adhesives

...ke an adhesive plaque, and it uses 20 or more such plaques to anchor itself," Wilker said. "A mussel can easily establish itself overnight." Key to the mussel's tenacity is the plaque, or glue, that holds these filaments in place, and it is the chemistry of this glue that Wilker and his fellow researchers a...

Researchers describe novel gene mutations associated with Alzheimer disease

...en accompanied by a buildup of certain proteins or plaques in the brain. Since 1991, the results of genetic studies have led to the identification of gene mutations and variations that can either cause AD or increase the risk for developing the disease. Familial Alzheimer disease (FAD), which accounts for ...

Visualizing Alzheimer's disease

...in St. Louis has watched as Alzheimer's-like brain plaques damage mouse brain cells. The results will be pres...chnique to examine the brains of mice that develop plaques similar to those characteristic of Alzheimer's disease. The mice also were engineered to have a subs...

High heart risk for lupus patients linked to death of cells lining blood vessels

...lacement of endothelial cells, which normally keep plaques and clots from forming in blood vessels. Loss of these cells through accelerated apoptosis may affect vascular and heart health in many ways, says Rajagopalan, since endothelial cells serve an important barrier function, and make nitric oxide that re...

Herpes research uncovers possible clue to Alzheimer's disease

...eaks down to form a major component of the amyloid plaques that are consistently present in the brains of persons with Alzheimer's disease. Amyloid precursor protein or APP breaks down to form beta-amyloid. There is strong evidence, according to the researchers, that beta-amyloid is the underlying cause of...

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