Tag: "precancerous" at biology news

Salvage Gene Is At The Root Of Many Mutations

...which is thought to occur because mutations permit precancerous cells to overcome the geneticdefenses against unlimited cell proliferation and migration." The Rochester researchers believe the findings could open a major new avenue of cancer prevention. People withgenetic predispositions to cancer could be g...

Gene For Inherited Syndrome Is Possible New Tumor Suppressor

...PJS). People who are born with ittypically develop precancerous polyps in theintestines in their teen years or later, and have freckle-like spots on thelips, around the mouth, and on the fingers. These individuals are also at a higher risk for a variety of cancers, includingthose of the intestine, breast, pancre...

Studies Underscore Link Between Nutrition And Nonmelanoma Skin Cancers

...g new nonmelanoma skin cancers include ahistory of precancerous lesions, fair skin, red or blond hair, early severesunburns and a history of intense sun exposure. Antioxidant vitamins with the ability to neutralize damagingfree-radical molecules produced as a byproduct of normal metabolism and byultravio...

Researchers Discover Ways The Ulcer/Cancer Bug Can Trigger Disease

...ed, as theydo in humans with atrophic gastritis, a precancerous condition. In a differentstudy, Gordon's group has shown that undifferentiated cells in the stomachlining proliferate abnormally when parietal cells are lost. Such unrestrainedcell division eventually may increase the risk of cancer, Gordon suggests....

Cell Pathways Reports Extension Study Results Showing Ability Of FGN-1 To Prevent Formation Of Precancerous Colon Polyps

...ed drug treatment well. Theprogressive increase in precancerous polyps that normally occurs in this patientpopulat...on average, a significant increasein the number of precancerous polyps that develop in their rectum over a 12month period," said Dr. van Stolk. "In contrast, we obs...

Finding Reveals Broader Role Of Telomerase Enzyme, Suggesting New Target For Extending Life Span Of Cell

...emoved the lastbarrier to immortal growth of these precancerous cells, revealing the enzyme tobe a cancer-romoting factor in cells already part way along the road tomalignancy. Blackburn's lab had previously observed the phenomenon of cell immortality andshortened telomeres in two yeast species, and she attribute...

Exisulind (Aptosyn™) and other SAANDs compounds halt prostate cancer cell growth by two mechanisms

...osis (programmed cell death) in abnormally growing precancerous and cancerous cells. Because SAANDs do not induce ...or patients with familial adenomatous polyposis, a precancerous condition that often leads to colon cancer, is currently under review by the U.S. Food and Drug Agen...

Aptosyn™ (exisulind) and other SAANDs target early event in cancer; AACR presentations detail novel apoptotic pathway

...death, or apoptosis, in a wide variety of abnormal precancerous and cancerous cells without causing the harmful ef...ht to play an important role in the development of precancerous lesions and ultimately cancer. Combining these findings with the broad pro-apoptotic activity seen ...

Cell pathways' SAANDs compounds enhance antitumor effects of Taxol™ in rodent models of breast cancer

...osis (programmed cell death) in abnormally growing precancerous and cancerous cells. Because SAANDs do not induce ...or patients with familial adenomatous polyposis, a precancerous condition that often leads to colon cancer, is currently under review by the U.S. Food and Drug Agen...

Asprin-like drugs may be useful for cancer treatment, study suggests

...to test the ability of COX-2 inhibitors to prevent precancerous polyps in the colon. In recent years, cancer researchers have turned to the field of angiogenesis as a hopeful avenue to fight cancer by more indirect means than traditional chemo- or radiation therapy. Tumors produce growth factors, such as VEGF, t...

Cell Pathways scientists describe mechanism by which SAANDS compounds trigger programmed death in cancerous and precancerous cells

...e been found to be over-expressed in cancerous and precancerous cells of the colon. The inhibition of these target...grammed cell death, or apoptosis, of cancerous and precancerous cells, but not normal ones. The drugs have additionally been shown to inhibit the growth of a broad ...

Cell studies may further gene therapy prospects for head and neck cancer

...ications for treating severe cellular dysplasia, a precancerous condition characterized by cellular abnormalities. These cells are undifferentiated and like cancer cells express the hCAR receptor. "So, theoretically, in people at high risk for cancer, adenoviral gene therapy would only infect the pre-cancerou...

UCSF-led study points to pivotal, early event in cancer development

... potential targets for prevention and therapy at a precancerous or early cancerous stage. Cells begin the slide toward the cancerous state when they start to accumulate mutations in the genes involved in regulating a cell's growth. Once enough critical genes have been affected, a cell progressively loses its c...

Study detailing safety and efficacy of exisulind in treating recurrent prostate cancer

...ly trigger programmed cell death, or apoptosis, in precancerous and cancerous cells but not normal cells. Research by Cell Pathways and others has demonstrated that these drugs achieve their pro-apoptotic effect by inhibiting specific cyclic GMP phosphodiesterases, thus allowing death of the abnormal cells to occ...

Genetic mutation may be key to onset of deadly skin cancer

...st and a team of collaborators have discovered how precancerous moles may progress to melanomas, the most deadly t...rs for the disease. Telling the difference between precancerous moles and early-stage melanoma can be very difficult, and the treatments for these two lesions diffe...

Black raspberries show multiple defenses in thwarting cancer

...geal cancer as well as inhibit precancerous growth already underway. "Bla... to inhibit the progression of precancerous cells to cancer. They conducted experiments on two groups of rats. Some of the ...

Anti-inflammatory drug fails to prevent a hereditary colon cancer

...al of Medicine, show that sulindac did not prevent precancerous growths, called polyps, in young patients with a hereditary form of colon cancer. The drug may still have benefit in reducing polyps in older patients. Researchers followed 41 patients ages eight to 25 with known genetic mutations that result in a f...

Hopkins researchers test new molecular marker for prostate cancer

...er. Similar overexpression patterns were found in precancerous lesions, called high grade prostatic intraepithelial neoplasia. "Since AMACR enzymatic activity is not found in most normal tissues, it could be an excellent candidate for the development of molecular probes for non-invasive detection of prostate ca...

Even moderate caloric restriction lowers cancer risk in mice

...ic restriction reduced by 60 percent the number of precancerous intestinal polyps in mice at high risk of gastroin...food to eat as well. The result: the number of the precancerous polyps also went down by 60 percent compared to the mice eating as much as they wanted. Previous mou...

Genetic testing, computer risk-assessment software prove effective in predicting breast cancer

...ese women correlated with Gail-model risk and with precancerous changes in the cells diagnosed by routine microscopy. "Our findings suggest that it is possible to develop an individualized approach to risk assessment using breast cells obtained by various methods," Euhus said. While the Gail method is accurate at...

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