Gene controls neural stem cell growth
...e had ever done a detailed study to understand the precise role of PTEN in the nervous system. Knocking out the gene in mice caused early death in embryos, before significant brain development. So, Wu and her colleagues used the Cre-loxP system to genetically manipulate the mice so that the gene would be kno...Researchers zero in on date of early hominids
...e formation that allowed them to hone in on a more precise date. What they also discovered was that the Erk-el-Ahmar magnetic profile matched almost exactly a magnetic profile taken from the ocean floor in the North Atlantic - research conducted under the auspices of the Ocean Drilling Program. "That validat...Researchers discover precise olfactory map
... reported genetic studies in mice that uncovered a precise sensory map in the olfactory cortex. The researchers also showed that this map is virtually identical in different individuals. Odor molecules that enter the nose are detected by odor receptors located on the surface of olfactory neurons. There are ...Efficient fertilizer use could benefit river without hurting crop yields
...and lead author of the Nature article.Although the precise cause-and-effect relationship between fertilizer use and the hypoxic zones is still uncertain, McIsaac said, the fact remains that nitrogen going into to the Mississippi River Basin increased faster than the amount of nitrogen harvested in crops in t...Discovery of dynamic sub-cellular processes could lead to medical applications
...racticable, the procedure could be used to deliver precise amounts of medicines to precise locations. In some applications, biotechnologists depend upon the secretion of compounds by cells to...Researchers discover 'thermostat' that regulates bone density
... protein 5 (LRP5), which codes for a protein whose precise cellular function remains unknown. I became interested in this extremely rare disease in 1993 after meeting three affected patients, said Warman, who is at Case Western Reserve University and University Hospitals of Cleveland. Their sever symptoms of...Anthrax genome may contain new clues to fight infection, says Science 'Functional Genomics' article
...rs therein, thus making strain identification more precise in patients and in environmental samples, Beauregard writes. Preliminary data from tests on anthrax used in the recent public health assaults point to an interesting evolutionary history, she continues. The detected bacteria show resistance to penici...New application of imaging technique can change how scientists look at proteins
...anotechnology. "But, for very large proteins, the precise correlation is poorly defined. Now we have a very efficient way of tracking changes in structure so we can see how it relates to what these large proteins do." Details of the new application of the technique, known as fluorescence resonance energy ......ive that will use those blueprints to identify the precise molecules a microbe uses to infect people and cause illness or even death. Through a six-year, $25 million contract, NIAID will establish a functional genomics resource center at The Institute for Genomic Research (TIGR) in Rockville, Md. The cente...Women more susceptible to orthostatic hypotension
...er, plasma norepinephrine concentrations are not a precise indicator of sympathetic outflow, and more direct measures are required to determine gender differences in sympathetic control during postural stress. Thus the purpose of the current study was to test the hypothesis that sympathetic adjustments to t...Protein may play role in sex chromosome inactivation
... While the researchers have not yet determined the precise nature of CTCFs interaction with Tsix , their experiments hint that it serves as an activator of the gene. Alternately, said Lee, CTCF binding sites might act as an insulator, blocking an unidentified enhancer from attaching to the Xist gene, preve...New view of bacteria-mineral interface to advance bioremediation
...rrangement of prisms to redirect the laser beam at precise angles to reach the locations we need." The size o...ing on the researcher's needs. "The smallest, most precise spot size we've been able to achieve is around 2 micrometers, about the size of an individual bacter...Jefferson scientists show how collagen gene mutation leads to osteoarthritis
...atural biological partners. "We think because this precise framework of cartilage is severely altered, it can... into a fibril-like structure and is arranged in a precise network, providing cartilage with great mechanical strength. Researchers have previously shown that ...Aquaporins - the perfect water filters of the cell
... parts (amino acids) at the channel interior. This precise control of the movements of water molecules was found to have a twofold function. First, water molecules are 'passed on' in an ordered way on their way through the channel, which drastically increases the water permeation rate. Second, the permeation...Science's Top Ten: nanoscale computing circuits named top scientific advance of 2001
...ting drugs, specific "smart bombs" targeted to the precise biochemical defects that cause certain cancers. This year, the U.S. Food and Drug Administration approved the drug Gleevec, which inhibits a faulty enzyme associated with one type of leukemia. Enzymes that influence the growth of cancer cells are pro...Control of fat cell development demonstrated using Sangamo BioSciences' ZFP technology
...signer transcription factors" made from ZFPs allow precise targeting to a particular gene or genes of interest. Since the over-expression or under-expression of individual genes is the basis for many diseases, the ability to regulate genes with engineered ZFPs has enormous potential therapeutic benefit.......ry and is applying its technology to determine the precise physiological context of drug targets that will better direct our experimental efforts and decrease the risks associated with drug development, said Dr. Charles Cohen, Chief Executive Officer of Cellzome. We are currently using this approach with hum...Assessing the risk of mad cow in sheep
...ures considerably and make the risk estimates more precise as we feed in results from screening studies and new experimental findings about the disease....A 2,000 year-old technique may hold the key to acupuncture's therapeutic effect
...t depression or yielding of tissues determined the precise position of each acupuncture point. For each location, right and left sides of the body were then randomly selected for acupuncture point and control point. On the side selected for control point, a disk-shaped template was centered on the acupunctur...Insect bites on plants reduce photosynthesis, imaging device shows
..., and varying levels of red fluorescence, denoting precise reductions in photosynthesis activity. They also found an almost 80-fold increase in the synthesis of furanocoumarins, a defensive chemical, suggesting that a plant may purposely turn down its photosynthetic machinery to boost its defensive capacity...