Tag: "predisposition" at biology news

Mapping a road to understanding human health

...ng diagnostic and therapeutic measures. Individual predisposition to disease and differential response to therapies are determined in part by variations in DNA sequence scattered throughout our genetic sequence called single-nucleotide polymorphisms, or SNPs. Many regions of the human genome bear common, telltale v...

JCI table of contents, December 15 2003

...a chronic inflammatory condition associated with a predisposition to colon cancer, is frequently characterized by damage to short, repetitive DNA sequences, referred to as microsatellite instability (MSI). A report from Curtis Harris and colleagues from the National Cancer Institute in the December 15 issue of the ...

Genetic info of cloned pigs may help babies before birth

...low birth-weight. "These children then have a high predisposition to a host of other illnesses and diseases -- coronary heart diseases, hypertension and diabetes. It's a far-reaching problem and there is really no clear understanding of why this happens," Piedrahita said. Piedrahita's lab analyzed the genes of the ...

Brain study shows some animals crave exercise

...e adds that the specially bred mice have a genetic predisposition to run longer distances. "They represent those few extreme individuals in the population with an intense desire or compulsion to run," he says. To understand what drives these mice to run faster and farther than the average mouse, Rhodes and his col...

A sweet tooth may be a 'marker' for the genetic risk for developing alcoholism

...ed by years of drinking or was linked to a genetic predisposition for alcoholism. Findings published in the Novembe...efore the onset of alcoholism and somehow reflects predisposition for this disease. Our present manuscript is focused on resolving this issue." Researchers recruited...

Variants of BMP2 gene as genetic risk factors for osteoporosis

...94 controls to look for variants that might confer predisposition to osteoporosis flagged several possible haplotypes (which were subsequently shown to be associated with osteoporosis in the larger cohort). These at-risk haplotypes, or versions of the BMP2 gene, were shown to approximately triple the likelihood of ...

Ethical guidelines needed before 'nutrigenomic' groceries come to market

...as determined, however, that most people's genetic predisposition to cardiovascular disease is determined by variations in scores of genes, each of which appears to lead to small increases in susceptibility. As well, it appears that one gene can be involved in a number of conditions. Genetic testing may only be abl...

Exercise and healthy weight delay cancer even among women with highest genetic risk

...ce the onset of cancer in women who have a genetic predisposition to cancer. "Living a healthy lifestyle, getting re...pone cancer onset in women with a strong inherited predisposition to this disease," Gralow said. Another finding of the paper is that many of the women did not necess...

Childhood brain tumors associated with rarely inherited BRCA2 gene mutations

...ncy of red blood cells, bone marrow failure, and a predisposition to cancer. The registry was established at The Rockefeller University in 1982 to address questions relating to diagnosis, prognosis, treatment, natural history of the disease, and cancer incidence in a large number of patients with this disorder. Acc...

NIH funds 'Breast Cancer and the Environmental Research Center' at Fox Chase Cancer Center

...during early critical periods of development alter predisposition for breast cancer. Dr. Coral Lamartiniere and his colleagues at the University of Alabama will investigate the potential of chemicals present in our environment to affect the development and differentiation of the mammary gland. These chemicals incl...

Adult alcoholism and attention-deficit hyperactivity disorder are connected

...m do not contribute to the putative common genetic predisposition for ADHD and alcohol dependence," said Johann. "However, several other candidate genes have yet to be investigated." Nonetheless, the findings do indicate a distinct phenotype, a way to measure an observable trait or behavior. Adult alcoholics with...

TIGR posts sequence data for parasite that causes trichomoniasis

..., low birth-weight, increased infant mortality and predisposition to cervical cancer. Given its prevalence and the role that T. vaginalis plays in several serious medical concerns, the ability to rapidly identify potential vaccine candidates for T. vaginalis, using genomic sequence, is a priority in the research c...

Powerful new method helps reveal genetic basis of cancer

...ll underlie many human traits, including heritable predisposition or resistance to disease. Background Information Relevant to the Development of ROMA In 1981, using a gene transfer method he pioneered, Wigler, working at Cold Spring Harbor Laboratory, discovered one of the first human oncogenes (the H-ras oncogene...

JCI Table of Contents

...hat this pattern of p40 expression may explain the predisposition of the terminal ileum to develop chronic inflammation responses via IL-23 and may therefore provide a molecular reason for the preferential clinical manifestation of Crohn disease in this region of the gut. In an accompanying commentary, Holm Uhlig a...

Couch potatoes may be created in the womb, not at the dinner table

...e influences obscure the linkage between metabolic predisposition and maturity-onset obesity. Past research has show... influences obscured the linkage between metabolic predisposition and maturity-onset obesity. This research is the first to clearly separate prenatal from postnatal e...

Genetics pioneer from the Bronx wins Gruber Prize

... match the genes. People with a particular genetic predisposition only get one subtype," he says. "And we already know this is a productive path. It has already worked with leukaemia. Eighty per cent of kids with childhood leukaemia now survive five years, due to advances in diagnosis which separates one subtype fr...

The magic behind merlin

...2, a hereditary cancer syndrome characterized by a predisposition to develop tumors of the central nervous system. Although NF2 was cloned a decade ago, this paper by Dr. McClatchey and colleagues provides unprecedented insight into the biological consequences of merlin loss and therefore its role in tumorigenesis....

Family communication about hereditary disease vital to prevention

...among members of families who have a known genetic predisposition to develop hereditary colon cancer. She studied whom the members shared their genetic test information with and why they chose to share it with certain family members and not others. "This is really about social relationships within a family and the ...

Symposium on how 'nature and nurture' impact child development

...l cross-fostering studies offspring with a genetic predisposition to fearfulness will be less fearful if raised by highly nurturing mothers, whereas even offspring genetically predisposed to be calmer, will be fearful if raised by poorly nurturing mothers. Maternal care appears to alter "gene expression", as reflec...

Laser-pulse technique could aid drug design

...ng a high fever, a small proportion with a genetic predisposition later develop epilepsy.) Using laser-pulse photolysis, Hess and his students discovered the reason for the receptor malfunction: a shift in the equilibrium from the open-channel form toward the closed-channel form. They also tested several compounds...

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