Duke Researchers Develop First Treatment For Rare Muscle Disease
...o the bloodstream. "But for Pompe disease, previous attempts at enzyme replacement therapyfailed because the enzyme was not taken up by the muscle cells," Chen said. "Wecircumvented this problem by using the body's own system to get the enzymeinside muscle cells." Chen solved the problem by p...When To Reproduce? It's All In The Timing
...corals, and plants such asseaweeds. The results of previous experiments and modeling studies haveconcluded that, when it comes to fertilization, these organisms don't have thatknack for good timing, i.e., that their rate of fertilization success borders onone percent or less. These studies have used ...Genetics May Explain Much Age-Related Hearing Loss
...oughly equivalent to 50-60 human years. As in the previous study, none ofthe mice had been exposed to interventions that could affect hearing. Mice lacking one component of the SOD gene had greater hearing loss thanthe control-group mice, particularly at the higher frequencies, results showed. The ...New Sensor Will Detech Chemical And Biological Pathogens At Incredibly Small Doses
...showed results that are 20 timesmore powerful than previous sensing devices. Velander, a biochemical engineer ... new biosensor, Velandar expanded upon some of his previous work. He adapted a technology he invented that is employed to purify pharmaceuticalspresent in blood...Hultgren Receives Prestigious Eli Lilly Award
... "AndI'm honored to be put on the same list as the previous recipients, which includemany distinguished microbiologists. I also have had the great fortune to workwith extremely talented and dedicated graduate students, postdoctoral fellowsand a research technician at Washington University. This award recogniz...Drug-Resistant Infection Once Found Only In Hospitals Now Present In Community
...ctor. Risk factors for infection were described as previous hospitalization orfrequent antibiotic use, history of intubation, an underlying chronic disorder,presence of a catheter, history of any surgical procedure, or household contactwith a person who has identified risk factors. The researchers also found ...Pet-Owning Couples Are Closer, Interact More Than Pet-Less Couples, UB Study Shows
...en and women, or dog- and cat-owners. Allen's previous research has shown that the presence of a pet during a stressful situation has a beneficial effect on blood pressure, and that for women living alone who have little contact with the outside world, a pet provides the same beneficial effects on cardio...Intake Of Acetaminophen Increases Risk Of Excessive Anticoagulation In Patients Taking Warfarin
...ased risk of having an INR over 6. Although some previous research suggested that acetaminophen might increasewarfarin's blood-thinning effect, Hylek notes, this is the first largedemonstration of its impact in usual clinical practice. "We don't want patients on anticoagulation therapy to avoid treating pa...User-Friendly Brace Helps Paraplegics To Walk
...ace is more versatile and easier to transport than previous models. It alsoallows the patient to bend his knees. The device was developed by a team fromTwente University of Technology and the R&D Institute at 'Het Roessinghrehabilitation centre' in Enschede. Funding was provided by the NetherlandsTechnology F...University At Buffalo Energy-Conservation Projects Record Highest Savings Among Campuses
...gy savings as the university had achieved over the previous 10 yearsthrough important, but piecemeal efforts. "Given that state resources will remain tight, this project gave us anopportunity to reallocate on-campus money that would otherwise be required topay our utility bills," Wagner said. "It's a total wi...Federal Food Aid Makes Healthier Children
...roved in children receiving food stamps. Although previous studies have looked at the benefits of the WIC program for pregnant women and the effects of food stamps on household diets, few studies have evaluated the effect of either program on nutrition, particularly in preschoolers. Yet, about half of the p...Virulent Fungus Devastating Potato Crops
... and tomato crops in the U.S. and Canada than were previous strains because it is resistant to the most effective fungicide, and because the strain is more aggressive. "Things are worse now than they were a few years ago," says Fry. He and Stephen B. Goodwin, a U.S. Department of Agriculture researcher at Pu...Heart and Soul: The Blood Vessels And Brain Use Common Guide
...do on the cancer cell itself? Klagsbrun notes that previous researchhas suggested VEGF can block a cell's genetic suicide program. Maybe VEGF, inaddition to its established effect on endothelial cells, also acts back on thetumor cells themselves to help them hold cell death at bay, he speculates. But ...New Gene Therapy Technique Results In 60 Percent Tumor Regression Rate
...l have suggested iteffectively kills cancer cells, previous studies used viral vectors to deliverthe HSV-TK gene to the cells. Since viral vectors aren't transient, it'spossible the viruses could infect healthy cells and cause mutations that couldbecome part of the genome. For this and other reasons, scientis...Sex Differences In Heart Disease May Be Due To Enzyme That Breaks Down Fat
...en andchange hepatic lipase levels, he says. In a previous study, co-author AlbertoZambon, a senior researcher at the University of Washington, found thatintensive therapy with lipid-lowering drugs decreases hepatic lipase in men andcauses coronary artery disease regression. Hepatic lipase activity ...Research: Breast Cancer Gene Screening Not Warranted For All
...iology at the UNC-CH School of PublicHealth. "Most previous comparable research took place among patients attendingspecialized cancer clinics so it was estimated that between 11 percent and 20percent of women carried a defective gene. We found the frequency of breastcancer due to BRCA1 to be considerably lowe...New Study Of BRCA1 Shows No Need For Widespread Screening Of American Women
...ng, whomapped the gene in 1990. "There has been no previous analysis of BRCA1 status ina series of patients identified simply because they have breast cancer,regardless of their ancestry and at any age." The researchers (Newman is a former graduate student of King) studied211 women from North Carolin...Computer Models Find Cost-Effective Solutions For Species Preservation
...same species." That's a significant advantage over previous methods forplanning the development of nature reserves. "What people havebeen using up until the last couple of years have been just rulesof thumb, not true mathematical optimization." Camm's computer model can be adjusted to handle both speciesdistr...One Year Follow-Up Of Non-Invasive Angina Treatment Suggests A Lasting Benefit
...ived sham counterpulsation.Fifty-seven percent had previous coronary artery bypass surgery orangioplasty, or both, and 49 percent had previous heart attacks. Neitherclinicians nor participants knew which patients received active treatmentor p...Dietary Determinants Of Iron Stores In A Free-Living Elderly Population: The Framingham Heart Study
...y (67--93 y of age), and dietary intake during the previous year was assessed by a food-frequency questionnaire. The relation between serum ferritin and various dietary factors was assessed by multiple regression analysis. Subjects whose ferritin concentrations might be pathologically elevated because of infe...