Enzyme's "Magic" May Hold Key to Anticancer and Antimicrobial Drugs
... role in cell division makes these enzymes prime targets for anticancer drugs. But until recently, scientists couldn't intentionally design such drugs because they knew so little about the enzymes. Now, the inner workings of one topoisomerase have been laid bare by a group ......cause major damage to our harbors and waterways. A prime example is the zebra mussel which has clogged water pipes in the Great Lakes region, causing millions of dollars of damage. Cohen, who works with the Energy and Resources Group at UC Berkeley, has previously reported the introduction of more than 2...Florida Company Using ORNL Technology For Revolutionary Wheelchair
...tsignificant technological innovations. "This is a prime example of how we can use knowledge gained in a specificarea for a particular purpose for other worthwhile endeavors," Killoughsaid. Cybertrax will integrate several unique technologies into its powerwheelchairs; however, ORNL's invention is the hear...Overweight Cats Risk Disease And Premature Death, Cornell Study Finds
...ebred cats are probably show cats that are kept in prime condition, Scarlett commented, and some of the more popular purebred cats, such as Siamese and Burmese, are thin animals to begin with. Cats eating some prescription diets for conditions other than weight are more likely to be overweight. That is ...Colon Cancer Linked To Genes, Not Lifestyle
...an genome, which makes them the prime animal model for researchers seeking answers to human diseases like cancer, AIDS and diabetes. "We have only now been able to study colon cancer and other aging-related dise...3-D Structure Of HIV Components May Pave The Way For New Anti-AIDS Drugs
...l genes intonew viral particles. The protein is a prime target for anti-AIDS drugs, becauseprevious studies have shown that when it is crippled, HIV cannot spread to othercells. New drugs that block the action of the RNA component could be equallyimportant. The detailed structure of the protein-RNA compl...Good Ergonomics Is Good Economics
... lines. Human factors design principles were given prime consideration, and an "inside-out" human-centered approach was taken, with the form of the truck being built around the operator's needs. The goal was to maximize operator comfort, minimize accident risks, and maximize productivity by optimizing task...Research Indicates Molecule Sabotage May Slow Brain Cancer
...s." BEHAB, also known asbrevican, appears to be a prime candidate for this type of therapy because itexists in glioma tumors, but not in other kinds of brain tumors or tissue in thebody, according to the scientists. In the new study, the researchers found that BEHAB must be secreted bythe tumor ce......is infection, but the current BCG vaccine fails to prime CD8 T cells for tuberculosis prevention. Over the last few years, Juergen Hess and Stefan H.E. Kaufmann from the Max Planck Institute for Infection Biology in Berlin and the University Clinics of Ulm developed recombinant ( r...Neurogenetics Lab Scan Suggests Genetic Linkage On Chromosomes 4 And 11
...dependent Finnish men, serotonin has recurred as a prime suspect in severe alcoholism," Dr. Goldman said. The Neurogenetics laboratory for some years has studied genetically and environmentally homogenous population isolates using a combination of whole genome linkage and direct analysis of candidate gen......d here. "Our results implicate HveC as the prime receptor for allowing HSV-1 andHSV-2 infection of mucosal surfaces and spread to the nervous system. It is aprime target for novel prophylactic or therapeutic interventions," Spear said. Ongoing research in Spear's laboratory is directed towa...Atmospheric Chemistry -- A Mysterious Isotope Effect In A Well-Known AtmosphericPollutant Discovered
...is simple rule of mass dependency is violated. The prime example of thisso-called mass-independent fractionation is ozone formation, in which 17O and18O are enriched almost equally (rather than in a 1:2 ratio). In the July24,vol.281, 1998 issue of "Science", T. Röckmann, C.A.M. Brenninkmeijer, G.Sauer...Security Code Helps Immune Cells Attack Foe And Spare Self
... inplace. But the two resting-state phosphates may prime the pump, Allen says. The study suggests that punching in the security code may buy time toproperly proofread the antigen, preventing the helper cell from making a hastydecision about whom to attack. "You must engage the receptor long enough...Fruit-Eating Birds Discovered Crucial To Rainforest Survival
...erminate successfully, making the birds one of the prime agents of lowlandrainforest regeneration. The resourceful hornbills may actually be nomads rather than migrants,wandering through the rainforest in search of fruit. Because of the difficultyof following the birds over great distances in the r...Novel Viral Vaccine Protects Aids In Animal Model
...gene-attenuated viral vaccineshave the capacity to prime that immune system to fight HIV. "We arecurrently treating KU-SHIV-1-infected monkeys with anti-HIV drugs to controlthe viral infection. Then we administer the vaccine to induce an HIV-fightingimmune response. Our goal is to build a therapy regimen a......r, Novartis and Janssen Pharmaceutica. "CBAMS is a prime example of the sort of start-up company which will be encouraged under the Science City York project," commented Professor Ron Cooke, Vice-Chancellor of the University of York. "CBAMS has worked closely with potential customers to purchase the world...Scientists Finger A Molecular Kingpin In Body's Response To Cigarettes
...s on these enzymes, andit's long been considered a prime suspect in smoking-related genedamage; a few years ago a team from the University of Californiaat Davis showed in the laboratory that the receptor seems to playan important role in the process. The Rochester team's results arethe first to demonstrate...Migratory songbird breeding linked to winter habitat
... a competitiveedge in reproducing: first choice of prime nesting sites and mates and anopportunity to replace eggs or nestlings that succumb to predation. But thefactors that give rise to early arrival have been poorly understood. To test their hypothesis that events taking place on the birds' winteringg...Major Clinical Findings By California AIDS Team: HIV Does More Than Kill Off T Cells
...D8--that are major playersin the immune system and prime targets of HIV. The technique was developed byMcCune and Marc Hellerstein, MD, PhD, the lead investigator of the study and anassociate professor at UCSF and at UC Berkeley. "We found that the virus had an impact on both the rate of T-cell productio......dence is very strong for manyplanetary bodies. The prime example is Titan [a moon of Saturn], which hasclouds of ethane and methane. They interchange with the surface, so there mustbe lakes or oceans of liquid ethane or methane. Once you know that, it's clearthey came outside from the body within." Thus,...