Tag: "prions" at biology news
Progress In Prion Research: Three-Dimensional Structure Of Prion Protein Fully Uncovered
... intact prion protein. In their malformed variant, prions
appear to induce human Creutzfeld-Jacobdisease, an... very rare occurrence so far. The disease-inducing prions
appear tocontain clumps of several prion protein molecules, which damage the brain ofaffected humans...
University Of California-San Francisco Researchers Report Test That Detects Prion Diseases, Illuminates Novel
Findings About Infectious Prions
...t the assay willultimately be useful for detecting prions
causing "mad cow" disease andCreutzfeldt-Jakob dis... each of the eight different strains of infectious prions
hadunique shapes. Researchers have known that prion diseases, even within species, vary inl...
New Evidence On How Prions Turn Fatal
...rmined structure of thebiological particles called prions
may help explain how they cause infectiousdeadly diseases. Aberrant prions
cause scrapie in sheep, bovine spongiformencephalopathy (BSE or "mad cow disease") in cows, and vari...
Deadly to cattle and humans, prions may help other organisms survive, researchers find
... at UC San Francisco have also found evidence that prions
might be far more common than had been previously ...otein, the first time a search has netted multiple prions
in the same organism. The discoveries and analysis are published in the January 21 issue of the jou...
Prions are modular
... protein misfolding chain reaction. Additionally, prions
are both "infectious" and heritable--they are pass...like. "We've discovered a method to create novel prions
which ultimately can have a lot of applications," said Lindquist. Previous research has shown tha...
Researchers show that proteins can transmit heritable traits
...pes, from one yeast generation to another. Yeast prions
are similar to mammalian prions
that have gained notoriety for their roles in such fatal brain-destroying human diseases as Creutzfe...
Ultrasensitive method for the diagnosis of prion diseases (Creutzfeldt-Jakob disease and BSE)
...n be identified inbody fluids. For the first time, prions
could be detected in the cerebrospinal fluid (CSF)...ever, suitable clinical tests for the detection of prions
in living patients or animals have not been available. A novel diagnostic technique now exists that...
Science: Prion proteins may signal trouble -- literally
...nternational journal, Science. While irregular prions
are the known culprits behind incurable "spongey-b...orm encephalopathies (TSEs), the purpose of normal prions
has remained mysterious until recently. According to research teams directed by Odile Kellermann ...
Prions may play crucial role in evolution.
...sm found in bread and beer, has prions, too. Yeast prions
are unrelated to the mammalian prions, and dont ha...ted from generation to generation. Because yeast prions
act much like mammalian prions
and are easier to study, scientists hope they will offer clues about ...
A dose of prions might slow the progress of prion diseases.
...ou could treat such diseases with a dose of normal prions
from another species. "It is an elegant mathem...auses the disease. But the build-up of hamster prions
in the mouse is worrying, Lansbury says. "Their presence may increase the rate of conversion of mous...
New finding may identify unknown agents of mad-cow disease
...protein can spark the formation of other unrelated prions
similar to the protein thought to cause mad cow an...is important, because much more is known about how prions
propagate than about how they first appearwhich also bears on public health concerns. Most cases of ...
UCSF study finds two old drugs may help fight prion diseases
...idually or in combination - have an effect against prions
in patients with advanced disease. Prion diseases ...dicate that the therapies were clearing infectious prions
from the brain's nerve cells. It would also indicate that nerve cells were actually recovering from ...
Scientists at the Scripps Research Institute find a way to block prions that cause mad cow disease
...her shape that is deadly," says Burton. Infectious prions
from an animal with mad cow disease, for instance,...ow to misform into the infectious form. Then these prions
will act on more normal prion protein to produce more and more misfolded protein that accumulates an...
Drugs, electronics, and 'green' catalysts: The chemical year in review
...in living patients. Sotos technique multiplies the prions
until they reach detectable levels. Vancomycin is the last line of defense against many bacterial infections, but recently doctors have seen a dangerous increase in bugs that the drug cant kill. Gabriela Chiosis of the Memorial Sloan Kettering Can...
UCSF prion finding in mice leads team to urge similar study in cattle
...rancisco researchers have made a finding regarding prions
in mice that they say warrants similar study in ca...chers have not investigated whether high levels of prions
amass in the skeletal muscle of cattle, sheep, deer or elk infected with prions. Substantial evidenc...
Misfolding the key to protein's ability to kill brain cells
...ered the mechanism behind how prions
pieces of protein molecules can ... While researchers knew that prions
were the causative agent for these diseases, just how they did their damage was...
Researchers find mechanism responsible for neuronal death in prion diseases
...re PrPSc conformation is unknown. The very idea of prions
makes many scientists uneasy because it violates t...s essential both to inheritance and infection. Yet prions
produce clumps in the brain that are infectious even though no nucleic acid seems to be involved. Pr...
UCSF-led team reports new test improves detection of prions in animals
...d a highly sensitive, automated test for detecting prions
(PREE-on) that they report significantly improves ...ed, high-affinity antibodies to reveal and measure prions
in brain tissue. As a result, it is able to directly measure infectious, abnormal prion protein. Th...
Mouse genetic model for spongiform brain diseases
...like mad cow disease, Gunn believes, because rogue prions
are not the cause of the mouse condition. But as an example of defective ubiquitination -- a protein-related process involved in many neurodegenerative disorders, including Parkinson's and Alzheimer's diseases -- the mahogany-colored mice with spongy...
Prions offer nanotech building tool
...racteristics that make misfolded proteins known as prions
such a pernicious medical threat in neurodegenerat...used the durable, self-assembling fibers formed by prions
as a template on which to deposit electricity-bearing gold and silver, creating electrical wire much...