Tag: "profile" at biology news

NIH awards $18.2m to The Burnham Institute to develop Center on Proteolytic Pathways

...mphasis on the use of activity-based proteomics to profile protease function. This approach, developed by Dr. Bogyo at Stanford, marks an innovation over other proteomics strategies because the activity-based approach reports on protease activity, as opposed to just abundance. In practical terms, Dr. Smit...

A long-necked sea predator from China described in Science

...murky near-shore waters before the predator's full profile scared off the potential meal. Based on Dinocephalosaurus' tooth and fang arrangement which is unlike other protorosaurs, the creature could have attacked with jaws opening sideways like a crocodile. Coauthor Michael LaBarbera from the University of...

Folic acid vitamin use by women reaches all-time high, March of Dimes survey finds

... 1995. "Although folic acid now has a higher profile in this country, we can't be complacent in our efforts to prevent disabling or fatal NTDs from occurring," said Dr. Howse. "We urge health care professionals and pharmacists to remember to use every contact they have with women capable of having a ba...

A liking for sweets, combined with novelty seeking, may predict alcoholism

...rch. First, does sweet preference and personality profile truly predict increased rates of alcohol problems? he asked. To answer this question will require prospective studies, similar to what other researchers have done with sensitivity to alcohol consumption. Second, what are the genetic/environmental m...

IBD (Crohn's, Colitis) 'joins' cancer, inflammatory diseases in associated blood vessel growth

...larization of both CD and UC displays an activated profile as shown by the expression of angiogenic marker V3 integrin. "Targeting this integrin could be a potential therapeutic approach for IBD," similar to approaches in other forms of chronic inflammation, Danese said. "These results provide the initial ma...

Researchers report new gene test for isolated cleft lip and palate

...l variations were then assembled into a collective profile called a "haplotype." "What we found is that a particular haplotype is over-transmitted in some families with isolated clefts, suggesting a predictive association with the birth defect, and this was true in the populations that we analyzed from The P...

Hopkins scientists use blood proteins to detect ovarian cancer

...on techniques. Then, researchers compared protein profile results in these two groups and ultimately narrowed the search for potential marker candidates to the three proteins, one of which (ITIH4) is commonly found at high levels in ovarian cancer and the other two at lower levels. "Typically, only half of...

Scientists identify compounds that mimic calorie restriction

...an be used like a bar-code to distinguish a unique profile from other genetic changes that occur in the body. The researchers compared the profile of calorie restriction with the profiles produced by compounds known to have some properties similar...

LA BioMed Medical/Research Briefs, July/August 2004

...points out that, "Black women might have a genetic profile that puts them at lower risk of getting breast cancer, but higher risk of this one specific high-grade tumor." Dr. Chelbowski is available by phone or e-mail at 310-222-2217 or rchlebow@whi.org . A Periodic Table For Biology In the June 21st edi...

AGU journal highlights - 29 July 2004

...ifornia. Chavarria et al. present vertical seismic profile results from theseismic monitors of the San Andreas Fault Observatory at Depth project. Theauthors state that the array of 32 seismometers, reaching more than two kilometers[one mile] below ground, can allow them to detect microearthquake waves and g...

Researchers uncover surprising degree of large-scale variation in the human genome

...the new study, Wigler's group created an extensive profile of such genetic variation in normal human DNA. The researchers sampled blood and multiple tissues from 20 individuals from a variety of geographic backgrounds. Differences in the chromosomal DNA purified from these samples were detected by ROMA. ...

Gene expression patterns may help predict risk and progression of prostate cancer

...gh throughput quantitative analysis to genetically profile prostate cancer tissue and noncancerous prostate t...eness of the disease and found that the expression profile model was more than 80 percent accurate in predicting the aggressiveness of the disease. "S...

Animal research suggests plant estrogens in soy do not increase breast cancer risk

...nopausal monkeys and may contribute to an estrogen profile associated with reduced breast cancer risk," said the researchers. Wood said it is important to note that the research addressed the effects of plant estrogens on normal breast tissue, and not in breast cancer. "A big unanswered question is whethe...

Harmless virus helps slow HIV by boosting immune proteins

...as a potential HIV treatment because of its safety profile and because patients would need only a limited number of exposures to see benefits. He and his colleagues are now considering a clinical trial in which HIV patients would be infected with the virus. "The fact that GBV-C is such a common infection, a...

Study finds that only half of a commonly used cancer drug is activated in cancer patients

...atical models were developed to calculate the time profile of drug concentrations in the body. "Although the study results demonstrate that administering gemcitabine as a 30-minute infusion resulted in approximately half of the dose being inactivated before it could be metabolized, the clinical implications ...

CSIRO research in greatest biotech show on earth

...e importance Australia places on our international profile in this rapidly moving business and scientific field." said Dr Hirsch. "We know from previous attendance at this event that Australian Science is as good or better than that of the rest of the world. In addition our R&D is very cost effective compar...

Researchers identify genetic markers to predict response to chemotherapy for colorectal cancer

...sed on the tumor's characteristics and the genetic profile of the person," said Carlini. "The ultimate goal is to tailor treatment that offers the most anti-tumor activity with the fewest side effects." In a separate study based on the same clinical trial, Fox Chase researchers also discovered a prote...

Maybe not so sweet, after all

...ents, "Fructose consumption results in a metabolic profile of hormones which would be predicted to increase f...d on our previously published work, this metabolic profile resembles that of fat consumption. Thus, despite the fact that fructose is a sugar, metabolically th...

Gene expression ratio identifies risk of recurrence in breast cancer patients receiving tamoxifen

...currence of their tumor or metastasis. Expression profile analysis demonstrated that the ratio between the expression levels of two genes HOXB13 and IL17BR was the strongest predictor of whether a tumor would recur. The higher the expression level of HOXB13 and the lower the expression of IL17BR, the gre...

The search for a safer smallpox vaccine: New data released on promising candidate

...1977 by vaccination, the vaccine had a poor safety profile and caused life-threatening diseases in a small, but significant proportion of the US population. "The threat of bioterrorism necessitates the development of new and safer vaccines and treatments against likely threat agents," Buller said. The smal...

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