ENBREL combo therapy inhibits joint damage progression, offers significant RA symptom relief
...ith the benefits and proven long-term tolerability profile of ENBREL. It has been used to treat over 180,000 patients worldwide since becoming commercially available four years ago. ENBREL acts by binding TNF, one of the dominant inflammatory cytokines or regulatory proteins that play an important role in b...JCI table of contents, 16 June 2003
...earchers have used microarray analysis to create a profile of all genes with altered expression in the lung tissue of mice with experimentally-induced asthma. Their results revealed high levels of arginase I and arginase II activity, suggesting that arginine metabolism pathways are critical in the pathogenes...Neural stem cells take a step closer to the clinic
...ison's Waisman Center describe the first molecular profile for human fetal neural stem cell lines that have been coaxed to thrive in culture for more than a year. The work is an in-depth analysis of global gene expression in human neural stem cells and demonstrates a method for prolonging the shelf life of c...U-M scientists find cancer's genetic core: 67 genes universally activated in human cancer
... Program. "The result was a common transcriptional profile with 67 activated genes present in nearly all canc...s containing thousands DNA probes that are used to profile tissue samples from malignant tumors. Scientists wash tissue samples on the microarray with a soluti...DNA arrays diagnose, predict survival for Sezary syndrome cancer patients
...ancerous cells to normal ones, the precise genetic profile for particular cancers at specific stages of their transformation can be determined. DNA arrays are allowing researchers to put to work information from the Human Genome Project about the estimated 35,000 human genes. In 1999, Showe became one of th...Study: Adults maintain significant improvement in ADHD with long-term use of amphetamine
...udied medication exhibited a positive tolerability profile during the extension trial. The majority of side effects that patients experienced were mild or moderate; those most frequently mentioned included dry mouth, loss of appetite, insomnia, and headache. "There are serious consequences associated with u...Automated imaging of brain tissue, high-quality glimpses inside arteries
... is unable to provide a detailed map or mechanical profile of the plaque that causes the blockage. The new system, incorporating several important technical advances in optical coherence tomography (OCT), employs all-fiber micro-optics (enabling tiny, high-quality imaging devices to be threaded through an a...KEPPRA international Phase IV SKATE study results show favourable efficacy
...t this type of seizure. Safety The adverse event profile was consistent with that seen in the Phase III clinical development program, with the five most commonly reported adverse events leading to discontinuation as follows; somnolence (2.2%), asthenia (fatigue) (1.8%), convulsions (1.8%), headache (1.4%...Early-life environments shape development of stress behaviors and learning abilities in mice
...ther, play a strong role in determining the stress profile and cognitive development of genetically identical...produced a cascading effect on the animals' stress profile and cognitive performance." Despite the growing conviction that genetics determine development, Fran...Clinical study reports findings of combination therapy with DOXIL
...to determine whether this would improve the safety profile and convenience of the treatment regimen without compromising efficacy. "This phase II study evaluated DVd as an alternative to the VAD regimen. With DVd, DOXIL is administered as a one hour infusion (compared to a 96 hour infusion with VAD, which a...As Vitamin B-6 levels go down, numbers of DNA strand breaks go up
...the researchers only measured the total lymphocyte profile rather than looking at subsets, which may have been affected differently. During the second month, the subjects ate only a carefully controlled diet that included 1.4 mg of Vitamin B-6 (dietary plus some supplementation), approximately the RDA. Duri...Proteomics drives new generation of medical treatment
...e sets. Researchers identified a specific protein profile that appears to distinguish early stage endometrial cancer samples from healthy samples. The data is under full investigation, but the use of the technology could potentially be a reliable screening method for the early detection of such diseases. ...Research shows high doses of acetaminophen clear rapidly and consistently from bloodstream
...undertaken to learn more about the pharmacokinetic profile of acetaminophen. It was not intended to explore the potential for increasing the recommended daily dosage of acetaminophen. "It is important that consumers continue to adhere to the recommended daily dosage of no more than 4 g of acetaminophen pe...Biomedical engineer constructs illuminating nanoparticles for medical imaging and gene detection
...genetic disorders. The particles might be able to profile a large number of genes and proteins simultaneously, allowing physicians to individualize cancer treatments based on the molecular differences in the cancers of various patients. Because of their novel structural and optical properties, these nanobe...Phase III study results with Raptiva in the treatment of psoriasis presented at Annual AAD meeting
...efficacy results combined with the emerging safety profile in more than 2,100 Raptiva-treated patients contribute to a favorable overall clinical profile for Raptiva as a potential once-weekly treatment for moderate-to-severe psoriasis." Data from 15 mon...Results from open-label Raptiva study suggest continued benefit with long-term treatment
...r an efficacious treatment with a favorable safety profile is of interest to clinicians as we explore potential therapies for this devastating disease." The most common adverse events during the first 12 weeks of treatment were headache, non-specific infection (e.g., common colds), chills, pain, nausea,...First step towards detecting exposure to biowarfare agents
...ys Jett. "New technology currently can be used to profile approximately 400 genes in a few hours. This offers possibilities utilizing host gene expression responses for rapid detection of potentially exposed individuals."...Australian overturns 15 years of nano-science doctrine
...ic force microscopy, small cantilevers are used to profile surface topography and structure. Shortly after the invention of the Atomic Force Microscope (AFM), almost two decades ago, V-shaped cantilevers were introduced to minimise the effect of lateral forces on image quality, a problem faced by the origina...Researchers pinpoint cause of inherited form of heart failure
...puzzle that are starting to come together to fit a profile of a group of patients who we think would very much benefit from modulating calcium homeostasis in heart cells," said Seidman. Additional research might well reveal that defects in calcium cycling could underlie some forms of hypertrophic cardiomyopa...New strategies against disease revealed as scientists probe genes' tasks
...tamp, called "DNA microarrays," that can provide a profile of all the genes being expressed in a given cell. The results are helping to shed light on health conditions from infectious disease to brain disorders, scientists reported during a series of seminars on "Microarrays and Functional Genomics" at the A...