Tag: "profiles" at biology news

Similar genetic origins possible for schizophrenia and bipolar disorder

...dividuals with neither disorder. "The expression profiles of most known oligodendrocyte-specific and myelin-associated genes were greatly reduced, and several transcription factors known to coordinate myelin gene expression showed corresponding changes," says Yolken. "These results provide strong evidence f...

Using GPR to estimate tree root biomass

...of factors that can affect the resolution of radar profiles of roots. Soil composition can cause background noise that interferes with resolution and alters the results," says Butnor. "For this study, we wanted to look at the full potential of GPR, so we chose a site with soil composition amenable to radar in...

NSF'S 'FIBR' to mix disciplines, use breakthroughs on 5-year explorations into biology's mysteries

...nnounced today include the following (see separate profiles for more detail): "The Evolution of Biological Social Systems," examining slime molds to study the evolution of biological social systems; Rice University (lead) and Baylor College of Medicine. "Integrated Ecological and Genomic Analysis of Speci...

Chemical change may help predict seriousness and course of some cancer

...neously. The researchers examined the methylation profiles of RASSF1A genes taken from 37 primary breast tumors, seven breast-cancer cell lines and 10 samples of normal breast tissue. Specifically, they measured methylation levels at 19 sites spanning two adjoining regions of the gene: the promoter region, w...

Illinois study seeking biomarkers of canine diabetes, other diseases

...eic acid (RNA) samples to generate gene expression profiles of some 384 genes associated with metabolism and i...her medical issues. The general study of metabolic profiles of cells, tissues and organisms is designed to identify molecular markers that reflect nutritional a...

Temple study identifies molecular mechanisms that may assist gene in blocking lung cancer

...lung cancer," says Giordano. "The gene expression profiles provided by microarray analysis will someday help tailor specific gene therapies to individual patients." Lung cancer is the leading cause of cancer death worldwide and is usually diagnosed at an incurable stage, most likely due to the absence of eff...

Gene expression tied to social behavior in honey bees

...Biology at Illinois, and colleagues generated mRNA profiles from 60 different bees who were working either as ...d outside). A computer program was able to use the profiles to determine correctly, for 57 of 60 the bees, which individual belonged to what group. Behavioral d...

NIH funds 'Breast Cancer and the Environmental Research Center' at Fox Chase Cancer Center

...mental chemicals induce in the genetic and protein profiles of the mammary gland. "This research should provide clues about the pathways that are responsible for modulating the susceptibility or resistance of the mammary tissue to carcinogenesis," explained Russo. Dr. Mary Wolff and her colleagues at Mt. Si...

NSF awards four-year, $3.9 million grant to plant biology team led by University of Georgia

... permit the simultaneous examination of expression profiles of 15,000 to 30,000 genes. Among a number of goals, the UGA research project will seek to improve LM for use on maize shoot apical meristems and then make the information available on a project web site. Profiles of global gene expression in the SAM...

PTEN and prostate cancer--the devil is in the doses

...o allow more accurate assessments. These molecular profiles can also help researchers design targeted, more efficient prostate cancer treatments. For example, if prostate tissue is hypersensitive to PTEN in humans--which the results suggest may be the case, since male mice with only 30% of normal PTEN levels ...

UB researchers show first evidence of pharmacogenomic differences in patients' responses to MS drug

...ex gene-expression modulation. The pharmacodynamic profiles indicate that changes in the gene expression occur as early as 1-4 hours of injection and that these changes modulate the immune system. "Our results support the premise that gene expression profiling using microarray techniques and studying the pha...

Ethical guidelines needed before 'nutrigenomic' groceries come to market

... dietary changes. Tests to determine genetic risk profiles are currently being offered by a small number of companies in Canada, the United States and the United Kingdom. At least two companies say the tests will help people choose diets that will improve their health. "In order to ensure that only the best...

Clock cells, tumor suicide, tailored therapies among subjects of AACR-NCI-EORTC Conference

...f head and neck cancer by examining the biological profiles of different tumors, which affect their responsiveness to radiotherapy. Scientists hope eventually to be able to tailor cancer therapy specifically to the biological behavior of an individual patient's tumor. "This is the foremost annual meeting ...

Gliomas' 'molecular fingerprint' predicts how aggressive tumor will be

... the researchers used mass spectrometry to develop profiles of proteins active in 60 human brain samples. These included 19 samples of normal tissue and 15 grade II, 11 grade III and 15 grade IV gliomas. The researchers identified more than 200 potential molecular markers that distinguished normal from mali...

Proteins may help identify patients who will respond better to treatments in certain cancers

...nvestigators looked at molecular marker expression profiles in 402 patients with head and neck squamous cell c...val and time to local treatment failure. Two tumor profiles were identified that had clearly different clinical outcomes. One group of tumors had a better-than-...

Mustard-root map breaks new ground tracking gene expression

...es were ground up and their global gene expression profiles determined, certainly generated much useful information. However, critical information on the mechanisms of development was lost. Development occurs at the single cell level, and there's a dramatic difference from one cell to the next, in terms of ...

Map of genes in plant root yields new tool for exploring tissue development

...es were ground up and their global gene expression profiles determined, certainly generated much useful information. However, critical information on the mechanisms of development was lost. Development occurs at the single cell level, and there's a dramatic difference from one cell to the next, in terms of it...

A first glance at global genetic networks

...re genetic networks. Analyzing the gene expression profiles of six distantly related organisms--bacteria, yeast, plant, nematode, fruitfly, and human--the researchers found that functionally related genes were co-expressed in each species. The most strongly conserved sets of co-expressed genes were associated...

Researchers unlock key secrets showing how tumors hide from immune system

...nology to study the characteristic gene expression profiles or "molecular signatures" of certain genes that are regulated by the STAT. Scientists suspect that many genes that are directly or indirectly regulated by Stat3 may contribute to cancer, and they are working to develop new drugs based on inhibiting S...

Predicting progression of common cancers

...e wound-like genetic signature with the expression profiles of various clinical tumor samples, they found the signature was always present in certain cancers--prostate and liver cell carcinomas--and occurred variably in others--breast, lung, and gastric carcinomas. In each of these three latter types of tumor...

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