Tag: "progenitor" at biology news
16 APS exercise research highlights, from reduced flu mortality to proteomics & obesity
...f the complex processes that regulate the myogenic progenitor
cell and characterize the discrete stages of the muscle repair process. 12.4 Natasha Frank, et al. (Children's Hospital Boston, Mass.) Expression of early developmental genes by human fetal skeletal muscle side population cells. Early development...
Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
...s consist of (1) adult stem cells, (2) endothelial progenitor
cells (blood vessel forming cells) and (3) other growth factor producing cells (tissue growth and repair promoting cells). These cells have practical benefits over other sources of regenerative-capable cells such as bone marrow, skeletal muscle, embr...
JCI table of contents September 15, 2004
...hile PDX-1 is known to be important for pancreatic progenitor
cell growth, these studies indicate that it also has a vital role in regulating adult b cell pro-liferation and is a key component of the mechanisms underlying compensatory b cell hyperplasia in response to insulin resistance. TITLE: PDX-1 haploinsuf...
New fruitfly model of diabetes has future implications for pancreatic cell transplantation
...imate development of these mature cells from their progenitor
cells. A better understanding of this process will help guide screening the human genome for genes that have a similar function in how alpha and beta cells develop. "This will be useful information for researchers trying to program undifferenti...
Researchers identify distinctive signature for metastatic prostate cancer
...gehog pathway might play in the function of normal progenitor
cells." To study the relationship of the Hedgehog...ures of cells that closely resemble these prostate progenitor
cells, the researchers found that switching on the Hedgehog pathway caused them to proliferate and f...
How do you mend a broken heart?
...rsity, Frankfurt) have pioneered human trials with progenitor
cells for cardiac repair. Progenitor cells can pro...rare and unanticipated population of adult cardiac progenitor
cells, and Bob Schwartz, who has made great advances in the understanding of cardiac gene expression...
Skin stem cells give hairless mice hair
... from embryos or from adult tissue -- are immature progenitor
cells with the capability to differentiate into a variety of specialized cells that form tissues and organs. Scientists are working toward using stem cells to grow mature specialized cells that could regenerate damaged or diseased skin, brain, heart ...
Leukemia stem cells identified by Stanford researchers
...l cells in the blood called granulocyte/macrophage progenitor
cells. This finding came as a surprise. Researcher...wapped chromosome, but only macrophage/granulocyte progenitor
cells become cancerous. Although the cancer stem cells still bore some resemblance to macrophage/gra...
Fundamental change to Immunology 101
...e marrow, from which all blood-cell types begin. A progenitor
cell must leave the bone marrow to seed the thymus...ugh, the thymus periodically imports marrow T-cell progenitor
cells via the circulatory system. The cell types that travel from the marrow to the thymus were not ...
JCI table of contents, 2 August, 2004
...ling. Both cells from the immune system and blood progenitor
cells are mobilized to the wound, but little is understood about the molecular mechanisms that regulate the activation and targeting of these bone-marrow cells and what roles they play in promoting or inhibiting repair. Elizabeth Nabel and colleague...
New drug shows promise against Gleevec resistance in mice
...the drug inhibits the proliferation of bone marrow progenitor
cells that are positive for BCR-ABL in patients who are resistant to Gleevec. "The bottom line is that our in vitro data indicate that this drug is active against all of the mutations except for one," Sawyers said. At the time Sawyers ...
Gene profiles could improve acute leukemia diagnosis and lead to better treatments
... in bone marrow hematopoietic stem cells (HSCs) or progenitor
cells that are destined to become myeloid cells (cells normally committed to fighting infections). Gene microarray technology uses small chips containing gene "probes" to measure the level of expression of thousands of specific genes simultaneously b...
JCI table of contents, 1 July 2004
...a defect in the production of platelets from their progenitor
cells called megakaryocytes, large cells found in the bone marrow. A defect in one copy of a gene called FLI1 causes this disease. The researchers, in investigating the expression of this gene, discovered it had an unexpected expression pattern. Most...
From lung to gut the Wnt signaling pathway transforms cell fate
...ed a cellular mechanism that can alter the fate of progenitor
cells that normally generate the lung, causing the...esults show that hyperactive Wnt signaling in lung progenitor
cells can induce a dramatic shift in lineage commitment and the generation of intestinal cell types,...
MacroPore - adipose-derived cells - potential to engraft & differentiate into heart muscle
...cells, which include adult stem cells, endothelial progenitor
cells and other growth factor producing cells, and which were discovered by scientists at MacroPore, have the potential to repair damage associated with injured cardiac muscle following heart attack. The study, conducted by a Macropore team led by Jo...
Oregon Stem Cell Center result of OHSU research strides
...ymal stem cells, neural stem cells and multipotent progenitor
cells, and can be used to create multiple cell types, including nerve cells, liver cells and muscle cells. They can be isolated from mice and primates, including humans, manipulated outside the living organism, and transplanted for reconstituting tis...
JCI table of contents, 15 March 2004
...hich degrade it. Osteoblasts come from mesenchymal progenitor
cells, which can also give rise to fat cells, called adipocytes. An intriguing fact is that in aging individuals while osteoblast development declines, there is an increase in the presence of adipocytes in the bone marrow. In the March 15 issue of ...
The bare bones of cutting the fat
...ich degrade it. Osteoblasts come from mesenchymal progenitor
cells, which can also give rise to fat cells, called adipocytes. An intriguing fact is that in aging individuals while osteoblast development declines, there is an increase in the presence of adipocytes in the bone marrow. In the March 15 issue of...
Crucial brain development gene identified
...leads to a loss of apical/basal polarity in neural progenitor
cells, failure of these cells to differentiate int...an overall increase in proliferation by the neural progenitor
cell population. The researchers believe that it is this increased number of proliferating cells tha...
Rb protein's role in retina development is key to understanding devastating eye cancer
...l as methods for knocking out Rb in single retinal progenitor
cells so the effect of this mutation could be studied in both embryos and newborn mice. A progenitor
cell is a "parent" cell that divides and multiplies, giving rise to specific types of cells. One wa...
1 2 3 4