The CIA Would Like To Know What Scientists Are Seeing Over The Rainbow
...tanding the changes that take place during disease progression could be greatly enhanced if we could study the en...e in identifying chromosome changes related to the progression of disease, the authors report that spectral karyotyping may be valuable in comparing genomes from d...Calorie Restriction Reduces Age-Related Muscle Loss
...itiated in late middle age apparently can slow the progression of thispervasive problem."...Newly Discovered Human Protein Provides Important Target For Cancer Therapy
...EST2 expressionor activity could halt or slow the progression of malignant tumors." In fact, say Meyerson and Counter, the foundation for an anti-telomerasedrug may already exist. The three known catalytic subunits of telomerase (fromhumans, yeast, and a protozoan, respectively) belong to the same gene...Molecular Piracy Turns Protein Into Traitor
... prevent initial infection or to slow down disease progression in an already infected patient. Importantly, this research shows for the first time that it is possible to block both types of chemokine receptor used by HIV with one molecule. "vMIP-II will help us understand the structural differences between these...Bowman Gray Scientists Find Novel Way To Block AIDS Virus
...ineof the disease-fighting CD4 lymphocytes and the progression to AIDS, and itsultimate downward spiral. Last year, in another dramatic discovery, a genetic defect in achemokine coreceptor was found to protect individuals with this defect fromHIV-1 infection. These genetically defective individuals rema...Herpes Virus Strain Identified As A Trigger In Multiple Sclerosis
...elieve that there may be a point intime during the progression of MS when the virus, which lies dormant in the bodyfor years, reactivates, accounting for its presence in a subset of MS patients.The study appears in the December 1997 issue of Nature Medicine(1). "We expect that currently available antiviral trea...Scientists Identify A Novel Mitotic Regulatory Mechanism
...he research teams suggest regulation of mitotic progression via a novel mechanism involving binding of a sp...s entry into mitosis and is required for proper progression through mitosis provided new insights with respect to the general design of drugs arresting ce......e delta 32 mutationsignificantly slows HIV disease progression in children born to seropositivemothers. Their wor...influence of delta 32heterozygosity on HIV disease progression in adults are that it is usuallydifficult to determine the precise date of infection and to rule out...Short-Course TB Prophylaxis Effective In HIV-Infected Individuals
...synergistic infections -- HIV infection speeds the progression of TB disease and increases the rate of activation of latent TB infection. TB appears to increase HIV replication in HIV-infected individuals." The World Health Organization (WHO) estimates that more than 5 million...UPMC Researchers Report On Gene Therapy Advances
...factor a (TNFa), boththought to be involved in the progression of the disease. "Inserting receptor blocking genes, similar to those seen in RA treatmentstudies, could abate the bone loss more efficiently than current treatmentoptions that deliver such 'blocker' proteins directly," said Dr. Robbins. Because IL-...Vitamin D Deficiency Appears Common In Hospital Patients
...ther important areas -- including muscle function, progression ofarthritis and aspects of the immune system," says Finkelstein. "Because vitaminD deficiency appears to be so common, more people probably should considertaking vitamin D supplements." Additional coauthors of the study are Donald Lloyd-Jones, MD, ...Genetic Make-Up May Determine Response To Cholesterol-Lowering Drugs
...e total group -- were about twice aslikely to have progression of atherosclerosis as those who do not have any copyof this variant. This suggests that one in 12 individuals who take this drugmay not benefit, she says. "So having this genetic information may help us better understand whatcauses unres...Soy Protein With Phytoestrogens Inhibit Atherosclerosis Progression As Well As Premarin
...strogens as well as mammalianestrogen inhibits the progression of atherosclerosis in postmenopausal monkeys,a Wak...s in the Premarin group, asignificant reduction in progression with the two treatments. The researchers also concluded: Premarin had the greatest e...Prostate Cancer Switch May Yield Map Of Cancer Machinery, Targets For Drugs
...plex changesprostate cancer cells undergo in their progression to a deadly form. Such a roadmap would yield not o...ce of being an important enabling component in the progression to metastasisand/or androgen independence." The finding is also important, Garcia-Blanco s...Research Indicates Molecule Sabotage May Slow Brain Cancer
...d hyaluronan binding protein (BEHAB), willslow the progression of the disease. "The experiments show that BEHAB appears to be a strong, central factorin the movement of brain cancer cells into healthy brain tissue," saysneurobiology professor and lead author of the study, Susan Hockfield, PhD, ofYale Uni...Possible Trigger For Heart Failure Identified In Lab Animal Studies
...ed 30 mice, diedprematurely of heart failure. The progression of heart failure was directlyrelated to the amount of TNF. Mice which did not express TNF in the heartproved to be free of disease, notes Deborah Bryant, B.S., the study's leadauthor. She is a senior research associate at U.T. Southwestern's depart......educed CD8+ cell antiviralresponse associated with progression to AIDS can be due to a decreased CD86expression on antigen presenting cells, such as macrophages. If it is, thisinformation could provide a direction for developing a drug to prevent it."......n equivalent to Ndt80 orRad17 might be involved in progression through the pachytene stage of spermdevelopment. Other research groups have reported a burst in cyclin synthesis at thepachytene stage of meiosis in both fly and mouse that resembles the actions ofNdt80. This suggests, say the UCSF rese...Homocysteine: A Possible Risk Factor For Alzheimer's Disease
...edial temporallobe, that can be used to follow the progression of Alzheimer's disease. Notes to editors: No interviews or further comments will be given by members ofthe OPTIMA team until publication of the full paper. More details about OPTIMA'sresearch are available on the OPTIMA website at http://www.pharm.......with high levels of this waxysubstance reduces the progression of atherosclerosis -- the build-up of fats andbiol...sterol lowering is likely to reduceatherosclerotic progression in most people with coronary heart disease across abroad range of pretreatment cholesterol levels," ...