Tag: "progression" at biology news

Researchers discover gene causing deadly infantile form of genetic kidney disease

...ne is a major step forward as the basic defect and progression of the disease can now be studied, said Peter C. Harris, Ph.D., of the Mayo Clinic and the lead researcher in the study. The identification of PKHD1 eventually will allow expectant parents to learn through confidential testing if their babies have a...

The path to a folded protein, long a subject of debate, appears in many cases to be long and winding

... proteins and are believed capable of blocking the progression of neurodegenerative disease. Rather than giving sluggish proteins the oomph to finish folding, the Penn work indicates that chaperones may return misfolded proteins to an unfolded state so they can start all over again. "In the skiing analogy, chap...

A new strategy for treating psoriasis

...-lived proteins, some of which could block disease progression by other mechanisms....

Study boosts suspected link between mothers gum disease and both premature birth, low birth weight

...t both periodontal disease and periodontal disease progression during pregnancy have an effect on the fetus, Offenbacher said. It increases the risk of pre-term delivery two-fold or greater depending on whether there is fetal exposure during pregnancy. This is complemented with new information suggesting that so...

PET better at finding recurrent breast cancer

...emission in these cases, it might have delayed the progression of disease. According to the American Cancer Society approximately 203,500 women will be diagnosed with breast cancer this year. The Center for Medicare and Medicaid Services (CMS) decided on February 27 to reimburse for FDG PET scans for staging pa...

Putting microRNAs in their place

...link between the pathway of miRNA activity and the progression of this common disease....

Enzyme once thought harmful to Alzheimers patients now appears key to future treatment

...rain neurons. This action might serve to delay the progression of Alzheimer's disease linked to a reduction in central cholinergic tone. This raises the possibility that induction of galanin by nerve growth factor may have a neuroprotective role. The Study To examine this theory, an investigation of the mechani...

Other highlights in the March 20 issue of JNCI

...ittle is known about the processes involved in the progression to cancer. COX-2 is an enzyme that is expressed i...thelial cells and may have relevance to neoplastic progression in Barrett's epithelium. The inhibition of COX-2 activity may, therefore, have chemopreventive poten...

Darwin's Time Machine: Scientists begin predicting evolution's next step

...ight cost that organism its life. In contrast, the progression of DOG, COG, COT, CAT is made up of single changes, but each change still creates a valid word. Likewise, in evolution, the series of mutations must remain viable at each stage. Hall found that the model could show along what path certain bacteria we...

Researchers develop blood test to diagnose Alzheimers-type changes in mice

...s suggests that blood Ab levels do not reflect the progression of the disease unless the animal has been given m266. According to DeMattos, blood Ab levels in humans also do not reflect the amount of amyloid plaques in the brain. The truly novel finding of our experiment is that a simple injection of m266 alter...

Candidate genes found which may play a role in cancer progressing from non-invasive to invasive

...ying a group of genes which may be involved in the progression of breast cancer from non-invasive to invasive, the 3rd European Breast Cancer Conference in Barcelona heard today (Thursday 21 March). Professor Craig Allred, Director of Breast Pathology at the Breast Center, Baylor College of Medicine, Houston, US...

Pinpointing the protein problem in Lou Gehrigs Disease

...different kind of mutation, experience a very slow progression and can survive for as long as 18 years, says Coln. The existence of SOD1 mutants associated with this milder form of FALS makes it an intriguing biophysical and biochemical marker. Unlocking the mystery of the pathogenic causes for FALS could also p...

UT Southwestern researchers discover how common MS drug slows progression of the disease

...r acetate, has long been known to slow or stop the progression of attacks in MS patients, researchers have not known exactly how the drug treated the disease. In the March issue of the Journal of Clinical Investigation, lead author Dr. Nitin Karandikar, UT Southwestern assistant professor of pathology and neuro...

Other highlights in the April 3 issue of JNCI

...ased expression of the gene may play a role in the progression of prostate cancer. Chun Jing, Youqiang Ke, Ph.D.,...nished expression may be involved in the malignant progression of prostate cancer. Their results appear in the April 3 issue of the Journal of the National Cancer...

Statins may prevent damage by Alzheimer's disease protein, USF study finds

...he effectiveness of statins to prevent or slow the progression of Alzheimer's disease in a mouse model for the neurodegenerative disease. The USF Roskamp Institute is dedicated to finding treatments for Alzheimer's disease and other neurological disorders....

U-M scientists find new genetic marker for prostate cancer

...hat many genes are involved in the development and progression of prostate cancer each controlling a different step in the process. In previous work leading to the AMACR discovery, researchers at the U-M Comprehensive Cancer Center analyzed more than 80 complementary DNA microarrays to assess gene expression pr...

Cell Pathways CP461 demonstrates multiple anti-cancer activities

...cted cells with low PDE5 and high cGMP exhibited a progression time of up to 72 hours versus vector control cells... revealed a novel role for this enzyme to regulate progression during the G2/M phase of the cell cycle. The altered progression during G2/M also appears to enhanc...

Findings give insight into how colon cells transform into precancerous polyps

...about how it is involved in cancer development and progression and as new drugs are developed to interrupt it. ...of age, and there was no difference in the size or progression of the polyps that developed in both groups. "So it appears that the next stage of tumor progression...

New indicators for predicting hypertension in African-American males

...ld be made early in life to minimize the onset and progression of cardiovascular disease....

UM Cancer researchers test custom-made vaccine for non-Hodgkin's lymphoma

...rest from the chemotherapy. If there is still no progression of their disease, two-thirds of the patients receive a vaccine crafted from their own tumor cells, plus an immune system stimulant, while one-third receive a vaccine using only a carrier protein and the stimulant, which may also activate the immune s...

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