Tag: "progression" at biology news
Targeted Genetics Collaborators Report Additional Phase I E1A Gene Therapy Data At American Society of Clinical Oncology Meeting
...had minor responses in treatedtumors despite tumor progression
at other untreated sites. In one of sixpatients who had repeat biopsies of treated tumors, no pathologic evidence oftumor was found. In four of seven patients evaluated to date, evidence of downregulation of HER-2/neu was reported. "This new data, ...
Cell Pathways Reports Extension Study Results Showing Ability Of FGN-1 To Prevent Formation Of Precancerous Colon Polyps
...thatsupports FGN-1's ability to prevent the normal progression
of disease inpatients with FAP," said Rifat Pamukcu, M.D., chief scientific officer andsenior vice president of research and development at Cell Pathways. "Leftuntreated, FAP patients invariably develop colon cancer." He noted that arandomized, place...
Social Disruption Leads To Shorter Survival In Monkeys With AIDS
...disruption in HIV-infected people could hasten the progression
of the disease. These data provide strong support for that notion," said Capitanio. The scientists collected data on monkeys inoculated with the simian immunodeficiency virus from four primate centers around the United States. The monkeys h...
HIV Infected Adults In UCSF Study Show Evidence Of Thymus Activity
...der 40 who were in the early stages of HIV disease progression
hadabundant thymic tissue, indicating that the thymus might be triggered intoaction by the first losses of T cells. The research findings are reported in the June 1 issue of the Journal ofClinical Investigation, with an accompanying commentary by Ant...
New Medication Means New Choices For Families Dealing With Alzheimers Disease
... drug, that doesn't stop thedisease, but slows the progression
of the disease," says Paul Kettl, M.D.,associate professor of psychiatry and acting chair of psychiatry at Penn State.Kettl is also chief of psychiatry with the Penn State Geisinger Health System inHershey, Pa. The results of the one-year st...
Neurons Control Brain Immunity: Neurotrophins As Regulators Of Antigen-Presentation In Microglial Cells
... might be involved in maintenance and progression
of neurodegenerative disease and whether interference with ongoing immune responses might modulate their natural history. The involvement of neurotrophic factors and their receptors gives a clue to an attractive site of poss...
Circulatory Device -- A Bridge To Recovery For Heart Failure?
...s -- which reduce the heart'sworkload to slow the progression
of the disease -- and heart transplantation. However, heart cells can not regenerate and drugs do little to help injuredheart cells recover pumping ability. For patients with advanced heart failure who do not respond to medications,heart transplantat...
A New Molecular Marker For Prostate Cancer
...olecular marker can be used tobetter predict tumor progression
in men with prostate cancer, the second-leadingcau...n in tumor cells have been shown topredict disease progression
in breast and colon cancer. Researchers divided the 96 tumors into three groups, based on the perce...
Jefferson Researchers Provide Leads To Potential Parkinson's Treatment
...oss of dopamine nerve terminals and slowed symptom progression
compared toParkinson's patients, matched for age and disease duration, who don't take GM1."-more-Parkinson disease/page 2 He explains, "We would expect to see a natural decline in dopaminenerve terminal in these patients, and in the GM1 group...
HIV Patients Often Experience Viral "Breakthrough," But May Still Remain
Healthy, San Francisco Study Finds
...ve not beenvery high, and we have seen very little progression
of HIV disease," Nienowsaid. "These findin...ondoesn't appear to lead automatically to clinical progression
of disease," headded. Donald Abrams, MD, chair of the Community Consortium and UCSF professo...
Fauci To Present New Insights Into HIV Latency At 12th World AIDS Conference
...ed withHIV, and ultimately, in the rate of disease progression
among HIV-infectedindividuals. Among these are factors intrinsic to the infected individual (the"host"), notably the network of immune signalling molecules (especiallycytokines and CC-chemokines) involved in the normal immune response. "Pro-inflam...
Long-Term Study Looks At HIV Positive Men With Few Signs Of Disease Progression,
10-18 Years After Seroconversion
...TNPs. Because of the link between viral levels and progression
to AIDS, theresearchers recommended that HIV positive individuals who have avoidedprogressing to AIDS for many years should consider starting the new combinationantiviral therapies if the amount of virus in their plasma rises to moderatelevels, even ...
Evidence From Old Tumors Foretells Which New Breast Cancer Patients Will RequireAdditional Treatment
... years. The study also provides insights into the progression
of breast cancers,suggesting that angiogenesis and metastasis are two separate and usuallysequential events. Decreased levels -- or mutant, nonfunctional versions -- of nm23 seem to appearsomewhat later than angiogenesis. Loss of nm23 appears to be...
New Evidence For Growth Factor Role In Crohns Disease
...h may play an importantrole in the development and progression
of Crohn's disease (CD), a chronic,incurable, and frequently disabling inflammatory bowel disorder, new researchshows. Scientists led by Dr. P. Kay Lund, professor of physiology at theUniversity of North Carolina School of Medicine have used r...
Scientists Find New Clues About Fatal Childhood Disease, Ataxia Telangiectasia
... that will help A-Tpatients and even slow down the progression
of their disease," says Brad Margus,President of the A-T Children's Project in Boca Raton, Florida. Margus alsostated his hope that, with a closer connection to p53 and cancer, the ATMprotein will now receive more attention than ever in the science ...
NIAID Scientists Discover HIV Disease-Slowing Mutation
...c mutation significantly delays the progression
of HIV disease, scientists at the N...nfection or have slower HIV disease progression
than individuals who produce normal CCR5 protein. This time, th...
University Of Texas Southwestern Researchers Develop New Test For Kidney Function
... accurate measurement is important when monitoring progression
of kidneydisease. The conventional methods using creatinine are prone to overestimatekidney function, which results in delayed therapeutic intervention," Seikalysaid. The new procedure involves injecting the patient with a small amount ofradioac...
Phase III Results Suggest Potent Antiviral Activity For Vertex And Glaxo Wellcomes Second-Generation HIV Protease Inhibitor Agenerase TM
...hsignificant reductions in AIDS-related deaths and progression
of disease. Protease inhibitors intervene late in the viral life cycle and are the onlyclass of drugs that block virus production in cells already infected with HIV. Data reported today by Dr. Goodgame are from Protocol 3001, an ongoingdouble-blind, ...
Ribozymes To The Rescue: New UF Gene Therapy Shows Promise For Treatment Of Inherited Blindness
...hat can--in laboratory animals--significantly slow progression
of retinitis pigmentosa, a leading cause of inherited human blindness. The weapon, a ribozyme manufactured in the laboratory, works by chopping up genetic messengers before they deliver the instructions of a mutant gene. "This is the first case we k...
Cedars-Sinai Scientist Finds Malignancy Gene In Tumor Cells
...ng hopes that a vital keyto cancer development and progression
may have been unmasked. Julia Y. Ljubimova, M.D., Ph.D., a cancer researcher in the Maxine DunitzNeurosurgical Institute at Cedars-Sinai Medical Center, announced the discoveryof a novel human malignancy-associated gene (MAG) in the October issue o...
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