Tag: "progression" at biology news

GLUT4 in membrane ruffles

...se homeostasis by muscle and thus help explain the progression of insulin resistance to diabetes....

Study detailing safety and efficacy of exisulind in treating recurrent prostate cancer

...e results suggest that exisulind may delay disease progression in men with recurrent prostate cancer and thus pro...riod. Dr. Goluboff said, Due to the slower disease progression in low-risk men, there was no significant difference in the PSA rise in the placebo-group compared t...

UCSF study finds two old drugs may help fight prion diseases

...this case, the drugs could perhaps prevent further progression of the disease, though they could also prove futile in prolonging the patients' lives. Alternatively, the drugs could prove ineffective in patients with advanced disease, but ultimately prove effective as prophylactics in patients who are infected w...

Trial drugs for Huntingtons disease inconclusive in slowing disease

...onal drugs remacemide and Coenzyme Q10 to slow the progression of Huntingtons disease showed that neither drug re...an agent many someday be found which will slow the progression of Huntingtons disease and other neurodegenerative disorders, said Eugene J. Oliver, Ph.D., program...

Fatal thrombotic disease in designer mice lacking vascular thrombomodulin

... Males and females show different rates of disease progression in this strain, but the basis of this effect and the possible relation with the coincidence of disease and sexual maturity remain mysterious....

U-M scientists reveal prostate cancer's molecular fingerprint. Study links proteins to patient prognosis.

...hat many genes are involved in the development and progression of prostate cancer - each controlling a different step in the process." While some of the genes identified in the U-M study are well known to cancer researchers, many others have never before been associated with prostate cancer. Two of these new gen...

Genetic mutation influences spread of AIDS; African population lacks mutation

...Estimates of infectivity, transmission and disease progression were based on recent HIV research, according to Kirschner. The model used demographic data and initial values for infection from UNAIDS surveys conducted in Malawi, Zimbabwe and Botswana. In the model population without the protective mutation, U-M r...

Corvas presents 3-D molecular structure of matriptase, first structural insight into new class of protease cancer targets

...rotease that has been implicated in the growth and progression of certain solid tumor cancers such as breast cancer. Highly selective and potent small molecule lead inhibitors of u-PA have been shown to inhibit angiogenesis and tumor growth in animal models. The Company has identified more than 70 cancer-assoc...

Alcohol researchers show 'friendly' virus slows HIV cell growth

... virus type C (GBV-C) appears to have retarded the progression of human immunodeficiency virus in a 12-year clini...rstanding the mechanism by which GBV-C retards HIV progression holds promise for designing new treatments that will prolong life for HIV-infected patients. "It may...

UGA researcher unlocks links between complex carbohydrates and spread of cancer

...asion. Inhibiting GnT-V activity appears to slow progression of some cancers. If Pierce can create a specific inhibitor of GnT-V that works in the body, preventing the spread of some cancers might be achieved with a simple injection. There are also diagnostic possibilities for Pierce's research. Diagnosing ...

Handling stress: life and death decisions at the cellular level

...tant in many pathological conditions including the progression of some neurodegenerative diseases such as Huntingtons and also in cancer. This pathway therefore offers potential targets for therapeutic intervention. The identification of critical components of this signaling pathway, such as JIP1, offers new r...

Tips from the Journals of the American Society for Microbiology: September 2001

...HCV infection appears to have little effect on HIV progression and treatment, HIV infection does affect HCV. Co-infected individuals appear to have higher levels of HCV in their blood, progress to liver damage more quickly and require different treatment regimens than individuals infected with HCV alone. On t...

Loss of new cell growth gene linked to certain human cancers

...d in cell growth may play an important role in the progression of some human cancers. The gene, called Cables, was discovered by the MGH team last year, and the latest results are published in the October 1 issue of Cancer Research. "The Cables gene may be an important tumor suppressor gene located on chromosom...

Sex differences in osmotic regulation of AVP and renal sodium handling

... systems, which may explain differences in disease progression between men and women. The mechanisms underlying gender differences in blood pressure regulation remain unknown but may include differences in body water and sodium regulation. Both estrogen and testosterone receptors are present in the hypothalamus ...

Women with rare lung disease found to also have high prevalence of meningiomas

...ity to supply oxygen to the rest of the body. The progression of the disease varies among patients as does survival, which may extend more than 20 years after diagnosis. According to Moss, patients with LAM are often misdiagnosed, partly because many of the early symptoms are similar to other lung diseases. "...

Black raspberries show multiple defenses in thwarting cancer

...fruit's ability to inhibit the progression of precancerous cells to cance... of these extracts to inhibit the development and progression of cancer," Stoner said. "As we identify these extracts, we will then ...

Phase 3 psoriatic arthritis data for ENBREL (etanercept) announced at a national scientific meeting

...for reducing signs and symptoms and inhibiting the progression of structural damage in patients with moderately to severely active RA. ENBREL is the only tumor necrosis factor (TNF) inhibitor approved for use without methotrexate. It is also the only TNF inhibitor approved for use as a first-line therapy for RA....

New Phase 2 study shows ankylosing spondylitis patients respond to ENBREL (etanercept)

...for reducing signs and symptoms and inhibiting the progression of structural damage in patients with moderately to severely active RA. ENBREL is the only tumor necrosis factor (TNF) inhibitor approved for use without methotrexate. It is also the only TNF inhibitor approved for use as a first-line therapy for RA....

Lymphoma gene found

...ot mutated. Dr. Sherr and colleagues studied tumor progression in a transgenic mouse strain that specifically over-expresses the Myc oncogene in lymphoid B cells. The abnormally high expression of Myc in lymphoid B cells induces lymphoma development and leukemia. The tumors that develop in these Myc transgenic m...

Lancet study shows DiaPep277 arrests progression of Type 1 diabetes

...n in a Phase II human clinical trial to arrest the progression of type 1 diabetes, prevent destruction of insulin... continued insulin production, suggesting that the progression of the disease may be prevented. This change in the immune response is diabetes-specific, suggestin...

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