Engineered mice point to new target for pain relief
...ave discovered a biological mechanism in mice that prolongs morphine's painkilling effects. Their findings could lead to the development of new drugs that make morphine last longer and relieve pain at lower doses. The researchers report in the Dec. 24 Science that morphine prevents pain longer and more co...Vitamin D deficiency and bowel diseases connected
...sease or something else? We don't know yet how it prolongs survival." "I think that if you are a patient who has been diagnosed with IBD, it would be best to continue to follow your personal physician's advice," says the College of Health and Human Development faculty member. "It wouldn't be a good idea t...Alcohol-intoxication slows bodys efforts to restore normal blood pressure after small blood loss
.... Molina. Delayed normalization of blood pressure prolongs the period of time tissues have inadequate oxygen supply, a particularly disastrous situation for heavy oxygen-using organs like the brain, liver and kidney. Abnormally low blood pressure and the bodys altered neural and hormonal signaling to resto...New drug boosts fight against HIV, researchers find
...e levels higher makes the drug far more potent and prolongs its effectiveness. This boosting of protease inhib...navir-ritonavir combination boosts drug levels and prolongs the half-life of the inhibitor, offering a more convenient and forgiving regimen for patients - with...Gene variant increases risk of cardiac arrhythmia for African-Americans
..." causing it to remain open slightly longer, which prolongs action potential duration and increases the excitability of cardiac muscle cells. This effect could cause transient conduction abnormalities between heart cells, contributing to arrhythmia risk. Finally, the scientists compared a computer simulation ...Zengen, Inc. announces novel approach to reduce organ rejection
...whether a-MSH treatment protects the allograft and prolongs survival in experimental heart transplantation, in the absence of immunosuppressive therapies. Donor cardiac grafts (Brown Norway) were transplanted into the abdomen of recipient (Lewis) rats. Treatments consisted of intraperitoneal injections of t...Fasting forestalls Huntington's disease in mice
...of Huntington's disease-like symptoms in mice, and prolongs the lives of affected rodents, according to investigators at the National Institute on Aging (NIA) Intramural Research Program. This animal study* is the first to suggest that a change in diet can influence the course of Huntington's disease. "If re...Immunization may prove therapeutic for prion diseases
...YU School of Medicine have found that immunization prolongs the incubation period for prion diseases such as Creutzfeldt-Jakob disease and may have therapeutic value for other neurodegenerative illness such as Alzheimer's disease. Results of their study are being presented at the American Academy of Neurology...Hydroxyurea therapy improves survival in most severely affected sickle cell patients
... the first study to evaluate whether the treatment prolongs life, announced the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health. The study of 299 adult sickle cell patients with moderate to severe forms of the disease, found that improved survival was related to the b...MIT helps unlock life-extending secrets of calorie restriction
...ight on why drastically restricting calorie intake prolongs life span in some organisms, MIT researchers report in the Jan. 1 issue of Genes & Development that lowering the level of a common coenzyme activates an anti-aging gene in yeast. Calorie restriction extends life span in a wide spectrum of organisms, ...Carnegie Mellon enhances Quantum Dot Corp. technology for long-term, live-animal imaging
... surface molecules by adding a second polymer coat prolongs the time quantum dots circulate in the body. "Because uncoated quantum dots are too fragile for most biological studies in vivo, the coating is the most critical step," explained Ballou, research scientist at the Molecular Biosensor and Imaging Cente...Inhibition of insulin-like growth factor receptor-1 as promising anticancer therapeutic
...ost significantly, IGF-1R suppresses tumor growth, prolongs survival, and enhances the antitumor effect of chemotherapy in clinically relevant mouse models of multiple myeloma and other hematological malignancies. The researchers also identify two small molecules that are selective inhibitors of IGF-1R and a...Harmless virus helps slow HIV by boosting immune proteins
...us known as GBV-C slows the progression of HIV and prolongs survival for many patients. The report appears in the June 19 issue of The Lancet, the leading British medical journal. The findings provide the clearest insight yet into the biological mechanisms of GBV-C, a benign cousin of the hepatitis C virus.......rs and his colleagues demonstrated that BMS-354825 prolongs survival of mice with CML. In tests with cultured human bone marrow cells, the researchers showed that the drug inhibits the proliferation of bone marrow progenitor cells that are positive for BCR-ABL in patients who are resistant to Gleevec. "The bo...