Novel therapeutic target identified in fight against Rheumatoid Arthritis
...cantly impaired in mice overexpressing synoviolin, promoting synovial hypoplasia and ultimately, joint disease. This research demonstrates the significance of synoviolin in regulating synovial hyperplasia and ultimately joint destruction in RA. It offers new insights into the etiology of RA and a novel targ...Madagascar to triple areas under protection
... is clearly leading the way towards this vision by promoting long-term partnerships with all sectors of civil society." Under the plan, the government will launch a consultative, science-based process to choose the best sites for new protected areas based on the need to protect large wild places and the identi...Countries find common ground to protect world's rarest gorilla
...l years researching the Cross River gorilla, while promoting conservation awareness and supporting government partners on law enforcement efforts....Scientists switch components in cell circuits: Possible new technology, therapy
...as N-WASP, which normally directs cells to move by promoting the build-up, or polymerization, of the protein actin. When the actin buildup pushes one edge of a cell, the cell moves in that direction. Actin polymerization is normally controlled in the cell by two signals "upstream" of the N-WASP protein. "We si...NIH announces strategy to accelerate medical research progress
...rprise is intended to address this crucial area by promoting better integration of existing clinical research networks, encouraging the development of technologies to improve the assessment of clinical outcomes, harmonizing regulatory processes and enhancing training for clinical researchers. Another major goa...JCI Table of Contents, 1 October, 2003
...0% of human breast cancers, plays a causal role in promoting cancer progression up to the stage of histologically aggressive but nonmetastatic disease. At the point when the disease spreads to additional tissue types and organs, TGF-beta appears to switch from a tumor suppressor to a pro-oncogenic factor. Thes...A realistic way to save rainforests
...ovides a direct link between looking for drugs and promoting conservation and economic development in biodiversity-rich countries." Coley adds: "Rainforests are disappearing at a terrifying rate. Searching for drugs in the rainforests of developing countries might be one solution. In our research, not only ar......damping the immune response in some situations and promoting it in others. The findings, published in the Octo...mmune response with one end of their structure and promoting it with the other." The immune system must ride a fine line in its protection of the lung, whose sur...Scientists develop advanced sensors for biological agent detection
...f mass destruction. Governments have been actively promoting research and development of new technologies for security applications, sensors, equipment, and analytical process. Technical Insights will hold a conference call at 1:00 p.m. (EDT)/ 10:00 a.m. (PDT) on October 9, 2002 to provide a summary and analys...Intraepithelial neoplasia may be a leading risk factor for prostate and ovarian cancers
...mal growth in the glands or ducts of the ovary) in promoting the development of ovarian cancer, researchers from the Arizona Cancer Center in Tucson examined the disorder, testing three main hypotheses. They first theorized that in normal-appearing ovarian surface epithelia, changes in the nuclear chromatin p...PTEN and prostate cancer--the devil is in the doses
...f PTEN levels could help tailor therapies based on promoting PTEN expression. For patients with complete loss of PTEN function, where this would not be an option, inhibiting the proteins made overactive through PTEN loss could prove effective. And these approaches could well hold true for other cancers involvi...Fruits offer powerful protection from skin cancer
...ibit UVB exposure-mediated increases in cell cycle promoting signals including the activation of cell division. Modulation of Ultraviolet Radiation B Induced Wnt-Signaling by Perillyl Alcohol in Human Keratinocytes (Abstract 1385) Perillyl alcohol (PEOH) is a food additive and a compound found naturally i...Golfing toward a greener environment
...viating foot pains of golfers; and they trap heat, promoting turf and root growth longer into autumn and earlier in spring. But, above all, he says, "The technology reuses a waste material that's hard to dispose while it protects the environment." Park estimates that about 72,000 tires would be needed to inclu...AACR and CEO Dr. Margaret Foti receive award for raising public awareness about melanoma
...this award for the role she and the AACR played in promoting the public awareness programs of the 'Billy Foundation' through their Annual Meetings and Public Forums, and their assistance in the early detection of melanoma via their hosting of the Foundation's Mole Patrol/free skin cancer screenings," said Kare...Six reporters reach the 'pinnacle of excellence'
...ic's understanding and appreciation of science, by promoting best practices in journalism," noted Alan I. Leshner, chief executive officer at the American Association for the Advancement of Science (AAAS) and executive publisher of its journal, Science. "Further, the winning entries then serve as teaching tool...New understanding of insulin's complexities needed to conquer diabetes
...insulin signaling by stimulating IRS2 synthesis or promoting its activity might be a useful approach to combating this public health issue. However, there is evidence that too much insulin activity may be detrimental, so "future work must better resolve the network of insulin responses that are generated in va...Use of new direct thrombin inhibitor may be as effective as current standard treatment
... immunologic, hemostatic, and vascular systems, by promoting research, clinical care, education, training, and advocacy in hematology. ...History of frog deformities suggests emerging disease
...ing the role nutrient enrichment of water plays in promoting the trematode parasite and amphibian deformities. All these factors being studied, Johnson hypothesizes, may come together, much in the same way that changes in the ecology of deer and mice, due to loss of predators and reforestation, led to the ris...2nd Annual CDB Symposium: Developmental Remodeling (March 29 - 31, 2004; Kobe, Japan)
...evelopmental biology and regeneration and aimed at promoting the free and timely exchange of research achievements. The first annual CDB Symposium, "The Origin and Formation of Multicellular Systems," was convened in March 2003. We are pleased to announce that the second symposium in the series will focus on t......imate. The lengthening growing season appears tobe promoting more carbon uptake by the vegetation than is being...ger the growing season. These changes appear to be promoting plant growth for the region. The longer growing season allows plants to remove more carbon dioxide f...