Researchers determine genetic cause of Timothy syndrome
...mutation was a hotspot in the genome that was more prone to spontaneous mutation, said Keating. "With these findings, we had a good handle on why this particular mutation would cause an arrhythmia and also how we could reduce the risk of arrhythmia in these children by blocking that channel," sa...No role for simian virus 40 in human pleural mesotheliomas
...ed to detect SV40 DNA in human tumors are uniquely prone to false-positive results. We hope these results will hasten progress on this deadly cancer." ...A novel, safer strategy for regulating gene expression
... well in human cells. One ribozyme was especially prone to cutting itself in two, and the researchers tweaked it to make it even more efficient. Next, they identified two compounds that strongly inhibit ribozyme self-cutting, and showed that they could be used to turn on ribozyme-containing genes in mamm...Recent evolution at a single gene may have brought down heart disease risk in some human groups
...w-expression version of the gene are slightly more prone to atherosclerosis, the narrowing of the arteries ...t created the variant occurred at a site unusually prone to genetic change. By comparing human DNA with that of a diverse range of other primates, they showe...Humans march to a faster genetic 'drummer' than primates, UC Riverside research says
...ittle understood sections of DNA are volatile, and prone to sudden mutations, or genomic rearrangements. At times the results are beneficial in that they give rise to new proteins or an altered gene regulation. Sometimes the mutations result in the growth of a cancer tumor, or some other genetic defect. T...Gene linked to cleft lip and palate identified
...ties in chewing, swallowing, and speaking, and are prone to frequent ear infections that can lead to hearing loss. Depending on the severity of the cleft, dental problems may also occur. Surgical repair is an important part of treatment for oral clefts, but is not a complete solution for many children. ...Study narrows search for genes placing men at increased risk for prostate cancer
...an prostate cancers in men who are not genetically prone to the disease. "This study focuses and intensifies the hunt for genes that increase a man's risk of prostate cancer," says the paper's senior author, Dr. Jeffrey M. Trent, Scientific Director of TGen in Phoenix, Arizona. "We needed this sort of mass...Infants sighs may 'reset' breathing regulation mechanism as well as help lungs develop
...pecially very small airways, or alveoli, which are prone to collapse. Thus sighs help keep the lungs inflated making them more efficient and possibly also improving the exchange of gases. On the clinical side, abnormalities of breathing control are occasionally seen in adults and infants, especially dur...Alterations in vitamin D receptor gene increase prostate, breast cancer risk
...ncreased risk for this cancer but may also be more prone to developing metastases. "Differences in the gene sequence for the vitamin D receptor are associated with breast cancer risk and may also be linked to disease progression" said Kay Colston, Ph.D., the senior author of the study, published in the Au...Study links high carbohydrate diet to increased breast cancer risk
...ets, particularly among populations or individuals prone to insulin resistance. However, one study is not enough to make major changes in diet, and more work on this topic is urgently needed," Willett said....Depression traced to overactive brain circuit
...n-regulating brain circuit is overactive in people prone to depression even when they are not depressed. Researchers discovered the abnormality in brains of those whose depressions relapsed when a key brain chemical messenger was experimentally reduced. Even when in remission, most subjects with a history...Genetic discovery could dramatically reduce need for liver transplants in children
.... In other words, infants with biliary atresia are prone to develop an inflammatory response against themselves, according to Dr. Bezerra. The study suggests that these inflammatory cells see the biliary system as a foreign target. Proof of this concept, however, requires additional studies. To determine ...Study by Tufts biologist provides window into progression of some degenerative diseases
...For example, in Huntington's disease the repeat is prone to expansion during sperm development, which leads to inheritance of even longer repeats in the resulting children and a worsening of the disease in the next generation. The CAG repeat also expands further in the affected brain cells of patients, wh......ve adverse and/or beneficial effects in an obesity prone strain of rats. The authors of "A long-term high-protein diet markedly reduces adipose tissue without major side-effects in Wistar male rats," are Magali Lacroix, Claire Gaudichon, Celine Morens, Veronique Mathe, Daniel Tome, and Jean-Francois Huneau......tory of selective breeding, many types of dogs are prone to genetic diseases that are difficult to study in humans, such as cancer, heart disease, deafness, blindness and autoimmune disorders. In addition, the dog is an important model for the genetics of behavior and is used extensively in pharmaceutical ...Comparing primate genomes offers insight into human evolution
...n humans was mapped to a genomic area that appears prone to instability in human, chimp, bonobo, and gorilla. This region has undergone modifications in each of the other descendent primate species, suggesting an evolutionary role. In humans, gene mutations in this region are also associated with the inher...Confidentiality of genetic databases questioned by Stanford researchers
...y have an interest in learning whether a person is prone to certain illnesses, and that malevolent individuals might also try to seek out this type of information. So Lin, along with advisor Russ Altman, MD, PhD, associate professor of genetics and of medicine, and statistics professor Art Owen, PhD, looke...Croatian skeletons reveal changing status of cancer in Europe across the centuries
...n the Croatian Skeletal Collection would have been prone to diseases such as syphilis, tuberculosis and leprosy (and we found evidence for each of these conditions in individuals in the collection) and these illnesses (and others) would certainly have contributed significantly to mortality in our ancestors...Existing drug may prevent brain injury and seizures in newborns
... can cause permanent changes making the brain more prone to seizures. "In a rat model, we have shown that early life seizures induced by hypoxic encephalopathy increase susceptibility to seizure-induced neuronal injury later in life," says Jensen. "We also know that this early seizure activity appears to...Two billion vulnerable to floods by 2050; number expected to double or more in two generations
...eas, people are less likely to evacuate from flood prone areas and in some cases fear leaving and potentially losing their possessions or their property claim. "The thousands of tragic casualties from flooding and Haiti and the Dominican Republic in recent weeks underline the extreme vulnerability o...