Genes expose secrets of sex on the side
... most successful in sowing wild oats passed on the proof in their genes. By using those genetic smoking guns, researchers at the University of Arizona in Tucson have developed new insights into ancient mating and migration patterns in humans. Men and women differed in their participation in reproduct...DHA-rich diet protects brain from Alzheimer's damage, UCLA study shows
...ported the findings on Sept. 2. "This is the first proof that our diets affect how our brain cells communicate with each other under the duress of Alzheimer's disease," explained Greg Cole, Ph.D., senior author and a professor of neurology at the David Geffen School of Medicine at UCLA. "We saw that a die...Heartless worms hold clues to cardiac arrhythmias, sudden death
...'s where the worm came in. "This paper is really a proof of principle of the utility of using C. elegans to search for these HERG-interacting proteins," Petersen said. Even though the worm doesn't have a heart, it does have a pharynx -- a muscular tube that "pumps" food inside. The pharynx, Petersen said, ...... Biology; Kobe, Japan) and colleagues has provided proof of principle that just such a display of individual body time may one day possible. The report, published in the August 3 issue of the Proceedings of the National Academy of Sciences , describes the analysis of the expression of more than 100 time-i...UCSD researchers are first to demonstrate molecular link between inflammation and cancer
...tumors were wounds that do not heal. Even without proof of the inflammation-cancer link, cancer therapies have been developed that utilize non-steroidal anti-inflammatory drugs (NSAIDs) to inhibit NF-kB and other mediators of inflammation, and to act as chemo-preventive agents that reduce the risk of gast...Location of potential familial lung cancer gene discovered
...t and time consuming. "This study is just further proof of the importance of cooperative efforts and large-scale science in genetic epidemiology research," said Daniela Seminara, Ph.D., NCI....Good bacteria trigger proteins to protect the gut
... they were healthy and normal. This was definitive proof that the beneficial effects of commensal bacteria were due to their recognition by TLRs and not their biological activity. "Now we know that this recognition has a completely unexpected and novel function -- triggering TLRs to control genes a...University of Pittsburgh medical center among first to implant heart assist device
...'t for them, I wouldn't be here today. I am living proof that this works." Last fall, UPMC was among the first centers to receive approval from the Centers for Medicare & Medicaid Services (CMS) to implant left ventricular assist systems approved by the FDA, and UPMC is only one of two approved centers in ...JCI Table of Contents, 15 July 2004
...ent of bone synthesizing cells called osteoblasts, proof that this entire family of drugs is involved in bone loss has yet to be established. F. Patrick Ross and colleagues, from the Washington University School of Medicine, investigate another standard PI used in HAART called ritonavir, which surprisingly...New paper in Science introduces revolutionary new paradigm for fishery management
...rs write, "Ideally, EBFM would shift the burden of proof so that fishing would not take place unless it could be shown not to harm key components of the ecosystem." In addition, an ecosystem-focused approach would stimulate research about ecosystem processes and the likely consequences of human actions. "E...LSU researcher discovers new bird
...g their find. Determined to obtain the proof he needed of his find, Lane returned to the region last November and played the recording of the bird's song. His attempt to attract his quarry failed and he once again went home empty-handed. Then, last month, Lane and some cohorts were in Peru con...Report outlines steps needed to lessen smallpox threat
...drugs are feasible, because there has been a clear proof of principle with drugs against HIV and herpes," said Harrison. "They demonstrate that relatively conventional kinds of drugs that target key viral enzymes can be important antiviral therapeutics." According to Harrison, three main scientific themes ...'Trap' crop saves Texas cross timbers melon production
...ther insect, the squash bug, was the culprit. The proof involved "Koch's postulates," a series of rules for finding the cause and vectors of disease. In use for more than 100 years. Koch's postulates have been used to identify causal agents behind everything from AIDS to simple bacterium-related diseases....UCSD team determines cellular stress within body is critical
...y 5, 2004, the research in mice provided the first proof that a specific transcription factor, a gene that acts as an "on-off" switch, is essential for normal cell proliferation under conditions of osmotic stress and is also necessary for the body's immune response to invading pathogens. Osmotic stress occ...Macrophages, not stem cells, correct liver disease by fusion
...t doesn't happen," he said. "I think the burden of proof is now on the people doing that work, to show that what they're seeing is not fusion."...APP reports Abraxane(TM) is active in breast cancer patients who failed taxol or taxotere
... form of paclitaxel, represents the first clinical proof of principle of this technology," said Patrick Soon-Shiong, M.D., Chairman, President and Chief Executive Officer of American Pharmaceutical Partners. "Our ultimate objective is to maximize the efficacy potential of chemotherapy including taxanes in...Other Highlights in the June 2 JNCI
... write, "The value of the present study may be the proof of principle that screening for an immune response to cancer-specific antigens by using protein microarrays could lead to improved biomarkers of disease." Contact: Sally Pobojewski, Senior Science Writer, University of Michigan Medical School, 734-7...Drug combo effective in advanced breast cancer
...es to further confirm the UCLA results and provide proof of principle. If the studies are successful, it will change the way breast cancer patients with this genetic alteration are treated, Pegram said....22-amino acid bacterium created by Scripps scientists
...Schultz and his colleagues have demonstrated, as a proof of principle, that it is technically possible to have mutually orthogonal systems operating at once in the same cell. This opens up the possibility of doing multiple site substitution with additional unnatural amino acids in the future.......a response throughout the day. "The first study is proof of principle blocking the dopamine transporter," Nutt said. "Now the question is, would Ritalin be the drug to do that? That's not clear." The paroxetine study was conducted on 14 people with varying severity of Parkinson's disease. Each was given t...