Transplant rejection averted by simple light exposure in Stanford animal study
...f the study. "The experiment not only provided the proof that these cells cause graft-versus-host disease, but also provides a way of thinking about how you might prevent it," said Engleman, who also directs the Stanford Blood Center. The study appears in the May issue of the journal Nature Medicine. Bone ...Mexican farmers effectively cultivate phenotypic diversity in maize
... This investigation has brought the first genetic proof that these cultivation practices, conducted on a small scale (village and region), are a key element in the evolution of maize and its diversity. In-situ conservation of so-called "farm" varieties of crop plants, following the example of maize, could...Jefferson scientists use gene therapy to restore function of damaged heart cells in lab
... heart failure treatment." "This study is the last proof of concept," he adds, noting that years of previous work in various animal models enabled the research team to reach this point. "Now we are dealing with human cells from failing human hearts," he says, noting that essentially these studies in human ...Functional food Safety aspects
...ive health risks. Therefore, apart from scientific proof of the beneficial effect of functional food, a well-founded safety evaluation is also necessary. In the opinion of the DFG Senate Commission on Food Safety, it is precisely these safety aspects that have not been adequately considered so far. For thi...Survey reports fall in stem cell transplants for breast cancer
...ve been invaluable as they have provided important proof of the concept that graft versus host may have potential, it is critical that we don't repeat the mistake that has occurred with autologous transplants in breast cancer a premature rush to conduct large numbers of transplants based on an overly opti...NIST-led research de-mystifies origins of 'junk' DNA
... (CARB) and a collaborator, who developed rigorous proof that these mysterious sections were added to DNA "late" in the evolution of life on earth--after the formation of modern-sized genes, which contain instructions for making proteins. A biologist with the Commerce Department's National Institute of St...UT Southwestern research halts narcolepsy symptoms
...sible assumption, our experiments provide a strong proof of concept that introducing into the brain a molecule that mimics the effect of orexin will be the fundamental cure for human narcolepsy," said Dr. Masashi Yanagisawa, professor of molecular genetics and the paper's senior author. Orexins are small ...Obesity drug inhibits prostate tumor growth
...teomics screening is an efficient way to determine proof of concept needed before a potential treatment can be refined for clinical trials: in a matter of weeks, Dr. Smith was able to glean the initial discovery that linked excessive fatty acid synthase activity with flawed metabolism in cancer cells, and...Breaking the rules on artifical blood
...levels are lowest. Is the apparent success of MP4 proof that Winslow and his colleagues are right? Not necessarily, says John Olson, an expert in blood substitutes at Rice University in Houston, Texas. He thinks MP4 works well simply because the coated haemolglobin is too big to squeeze into the spaces be...Research suggests new way to repair cartilage damage
...ace it, Setton said. Calling the work a promising proof of concept, Setton said there is much work still to be done. Setton is working with Dana Nettles to optimize the properties that will make the hyaluronan polymer treatment most effective. For example, the researchers need to determine the pore size t...Baker's yeast rises from genome duplication
...called whole genome duplication, but no definitive proof existed. The Broad Institute work shows conclusive...two regions of baker's yeast, providing definitive proof of duplication. Researchers speculate that vertebrates, including human ancestors, may have undergon...New imaging technique developed to identify breast cancer
...ll eight of the malignant tumors. "These data are proof of principle, and strongly suggest that MRSI can serve as an important adjunct to the routine MRI scan that may aid physicians in making a diagnosis of breast cancer," says Jacobs. "We can envision a time when this procedure may even replace the need...Carbohydrates offer some help in muscle protein synthesis, but not enough for the desired effect
... A visit to the meat counter at any supermarket is proof positive that a good number of Americans are avoiding carbohydrates and consuming high levels of protein and fat, in accordance with the Atkins diet. This carbohydrate-free, fat- and protein- rich diet is for those seeking immediate weight loss, whic...Scientists, lawyers discuss decision-making amid uncertainty
... they will remain neutral, Schneider offers living proof that the "scientist-advocate" is not an oxymoron. "Among the positions one can take is being an advocate of science itself," he says, "in which one argues for a rational world view and has faith that science has something constructive to contribute t...Computer scientists develop tool for mining genomic data
...rom putting all of these snapshots together.'' The proof of concept for Koller's targeted hypotheses came in a June 2003 Nature Genetics publication, which described the application of her tools to predict gene regulatory networks in a variety of biological processes in yeast. Three of these predictions we...Immune system's attack dogs kept on genetic leash
... week's issue of Science, are the first scientific proof of a theory that could open up a significant new front in the battle to control autoimmune diseases like lupus, multiple sclerosis and diabetes. "We used to think of mature immune cells like T cells and B cells as metabolically inactive when waiting...Human embryonic stem cells may promise medical advances
...o still more specific cell types, offering further proof of pluripotency. Interestingly, the research team harvested eggs as well as somatic cells from the same donors: Nuclear material from the somatic cell was transferred into the nucleus-free or enucleated egg of the same woman. This unusual experimenta...UT Southwestern researchers find leptin turns fat-storing cells into fat-burning cells
...wed the increase in mitochondria there was not any proof of what was happening, but there were many clues that the fat was being burned inside the cell," Dr. Unger said. Collaborating with researchers at the University of Geneva Medical School, who conducted morphological tests to analyze the form and stru...Rodents bred for alcohol preference live longer than rats bred for alcohol avoidance
...r cautioned against interpreting these findings as proof that alcohol consumption is harm-free. "As difficult as human studies in the area are, they still give strong evidence that chronic intake of large amounts of alcohol is detrimental," he said. Hyyti concurred. "When we compare this study with h...Cells' ability to open blood's floodgates hinges on unexpected factors
...ect in humans," Williamson says. "They needed some proof that the principle might be applicable to the visual region of the brain in humans, and they found that it is." For the human research, seven subjects were studied using PET imaging scans. Participants were either asked to close their eyes during the...